Antibiotic Synthesis, 2nd Edition

A special issue of Antibiotics (ISSN 2079-6382). This special issue belongs to the section "Novel Antimicrobial Agents".

Deadline for manuscript submissions: 31 March 2026 | Viewed by 16

Special Issue Editors

School of Chemistry, University of New South Wales (UNSW Sydney), Sydney, NSW 2052, Australia
Interests: medicinal chemistry; antimicrobials; peptidomimetics; quorum sensing; Antibiofilm
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

The emergence of multidrug-resistant bacteria threatens the effectiveness of current antibiotics. It is projected that by 2050, antimicrobial resistance will cause 10 million deaths annually. Bacteria continue to evolve at a rate that surpasses drug development, highlighting a necessity for new drugs with mechanisms that inhibit resistance development. Furthermore, this situation is exacerbated by a reduction in the pace of development of novel classes of antibiotics.

Potential strategies to overcome this dilemma are highlighted below:

i) Discovery of new antimicrobial agents from natural sources and their synthetic derivatives;
ii) The design and synthesis of antimicrobial compounds with novel mechanisms of action;
iii)  Targeted delivery of antimicrobial agents;
iv) Combination therapy involving antibiotics and new antimicrobial agents;
v) Synthesis of dual- and multi-action antibiotics;
vi) Synthesis of adjuvants to enhance the potency of antibiotics;
vii) Exploiting innate bacterial responses to develop new antibiotics.

The Special Issue will publish contemporary research on the discovery and development of new classes of antibiotic compounds, as well as dual-action antimicrobials and other combination strategies. It is my pleasure to invite submissions of high-quality research-based papers related to the topics mentioned above.

Prof. Dr. Naresh Kumar
Dr. Tsz Tin Yu
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Antibiotics is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • new antimicrobial compounds
  • dual-action antimicrobials
  • new antimicrobial targets
  • targeted delivery of antibiotics
  • new scaffolds for antimicrobial discovery
  • discovery of new antimicrobial mechanisms

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Published Papers

This special issue is now open for submission.
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