Design and Synthesis of Quorum-Sensing Inhibitors
A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Organic Chemistry".
Deadline for manuscript submissions: closed (15 October 2017) | Viewed by 21141
Special Issue Editor
Interests: biologically active molecules; medicinal chemistry; organic chemical synthesis; peptidomimetics; novel antimicrobials; biomaterials
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
With the long-term overuse and misuse of antibiotics, the problem of antibiotic-resistance is now reaching a critical stage. Antibiotics are no longer the magic bullets they were once thought to be and therefore there is an urgent need for development of alternative therapeutic strategies to combat infections without inducing drug resistance. Quorum-sensing (QS) inhibition presents a promising alternative strategy, since it attenuates bacterial virulence by disrupting the signaling pathway between bacteria without inducing stress.
Several strategies to combat this problem are discussed:
i) Isolation of natural products with quorum sensing (QS) inhibitory activities and developing their synthetic analogues;
ii) Synthesis of new classes of QSI with anti-virulence and anti-biofilm properties;
iii) Rational design of QSIs;
iv) Structure-activity relationship studies of QSIs;
v) Applications and targeted delivery of QSIs;
vi) Dual-action and hybrid QSIs;
vii) Synergistic activities of QSIs.
Molecules will publish a Special Issue focusing on the “Design and Synthesis of Quorum-Sensing Inhibitors”, as well as novel molecular targets with reduced capacity to develop antibiotic resistance. It is my pleasure to invite submissions of high quality research-based papers related to the topics mentioned above.
Prof. Naresh Kumar
Guest Editor
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Keywords
- Discovery of new classes of quorum sensing inhibitors
- Synthesis of quorum sensing inhibitors with antimicrobial activity
- Rational design of quorum sensing inhibitors
- Development of methods for the targeted delivery of quorum sensing inhibitors
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