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Article

The Array of Antibacterial Action of Protocatechuic Acid Ethyl Ester and Erythromycin on Staphylococcal Strains

Department of Microbiology and Virology, Faculty of Pharmaceutical Sciences in Sosnowiec, Medical University of Silesia in Katowice, Jagiellońska 4, 41-200 Sosnowiec, Poland
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Author to whom correspondence should be addressed.
Academic Editors: Valério Monteiro-Neto and Elizabeth S. Fernandes
Antibiotics 2022, 11(7), 848; https://doi.org/10.3390/antibiotics11070848
Received: 26 May 2022 / Revised: 18 June 2022 / Accepted: 22 June 2022 / Published: 24 June 2022
(This article belongs to the Special Issue Antimicrobial and Anti-infective Activity of Natural Products)
The spread of antibiotic resistance among bacteria has become one of the major health problems worldwide. Methicillin-resistant staphylococcal strains are especially dangerous because they are often resistant to other antibiotics. The increasing insensitivity to macrolides, lincosamides and streptogramin B antibiotics of methicillin-resistant staphylococcal isolates has limited the use of these drugs in therapy. The combination of natural compounds and antibiotics can be considered as an alternative tool to fight multi-drug-resistant pathogen infections. The aim of the presented study was to examine the antibacterial activity of protocatechuic acid ethyl ester–erythromycin combination towards Staphylococcus aureus and Staphylococcus epidermidis strains with various resistance profiles to methicillin and macrolides, lincosamides and streptogramin B (MLSB) antibiotics. The in-vitro antibacterial potential of the above combination was investigated by minimum inhibitory concentration assays and checkerboard testing. The observed effects were strain dependent, with 8 of 12 tested staphylococcal strains showing an indifferent effect on the natural compound and erythromycin; for 2 strains, the tested combination had an additive effect, while for another 2, the effect was synergistic. Interestingly, the multi-drug-resistant strains were more sensitive to the cooperative action of the protocatechuic acid ethyl ester and the antibiotic. View Full-Text
Keywords: protocatechuic acid ethyl ester; erythromycin; fractional inhibitory concentration; Staphylococcus spp. protocatechuic acid ethyl ester; erythromycin; fractional inhibitory concentration; Staphylococcus spp.
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MDPI and ACS Style

Miklasińska-Majdanik, M.; Kępa, M.; Kulczak, M.; Ochwat, M.; Wąsik, T.J. The Array of Antibacterial Action of Protocatechuic Acid Ethyl Ester and Erythromycin on Staphylococcal Strains. Antibiotics 2022, 11, 848. https://doi.org/10.3390/antibiotics11070848

AMA Style

Miklasińska-Majdanik M, Kępa M, Kulczak M, Ochwat M, Wąsik TJ. The Array of Antibacterial Action of Protocatechuic Acid Ethyl Ester and Erythromycin on Staphylococcal Strains. Antibiotics. 2022; 11(7):848. https://doi.org/10.3390/antibiotics11070848

Chicago/Turabian Style

Miklasińska-Majdanik, Maria, Małgorzata Kępa, Monika Kulczak, Maciej Ochwat, and Tomasz J. Wąsik. 2022. "The Array of Antibacterial Action of Protocatechuic Acid Ethyl Ester and Erythromycin on Staphylococcal Strains" Antibiotics 11, no. 7: 848. https://doi.org/10.3390/antibiotics11070848

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