Special Issue "Advances in Equine Metabolomics"

A special issue of Animals (ISSN 2076-2615). This special issue belongs to the section "Equids".

Deadline for manuscript submissions: 31 December 2021.

Special Issue Editors

Dr. Claudia Giannetto
E-Mail Website
Guest Editor
Department of Veterinary Science, University of Messina, Polo University Annunziata, Messina, Italy
Interests: athletic horse; chronophysiology; exercise physiology; domestic animals
Special Issues and Collections in MDPI journals
Prof. Dr. Giuseppe Piccione
E-Mail Website
Guest Editor
Department of Veterinary Science, University of Messina, Polo University Annunziata, Messina, Italy
Interests: athletic horse; chronophysiology; exercise physiology; domestic animals
Dr. Francesca Arfuso
E-Mail Website
Guest Editor
Department of Veterinary Sciences, University of Messina, Polo Universitario dell’Annunziata, 98168 Messina, Italy
Interests: athletic horse; chronophysiology; exercise physiology; domestic animals
Special Issues and Collections in MDPI journals

Special Issue Information

Dear Colleagues,

The study of metabolites makes it possible to observe changes in the chemical and biochemical composition of biological fluids and tissues. The evaluation of metabolite profiles makes it possible to identify alterations to an organism’s physiology and/or the mechanism of adaptation of the animal in an attempt to restore homeostasis during various physiological and management conditions (e.g., pregnancy, lactation, neonatal period, aging, exercise, transport). To investigate the complexity of these responses, “omics” approaches including multivariate and large-scale analyses may be applied. Pioneering proteomic studies have demonstrated that variation in the proteomic fingerprint occurs in healthy animals during peculiar physiological states. The horse is an optimal in vivo model for characterizing physiological responses to homeostasis perturbation due to their natural aptitude for athletic performance and the homogeneity of their genetic and environmental backgrounds. In line with this, the Special Issue welcomes metabolomics studies developing insight into the metabolic adaptations and perturbations associated with any physiological state of life in equids.

Dr. Claudia Giannetto
Prof. Dr. Giuseppe Piccione
Dr. Francesca Arfuso
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Animals is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1800 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • metabolites
  • horse
  • exercise
  • peripartum
  • neonatal period
  • stress
  • aging

Published Papers (1 paper)

Order results
Result details
Select all
Export citation of selected articles as:

Research

Article
Preliminary Study: Proteomic Profiling Uncovers Potential Proteins for Biomonitoring Equine Melanocytic Neoplasm
Animals 2021, 11(7), 1913; https://doi.org/10.3390/ani11071913 - 27 Jun 2021
Viewed by 450
Abstract
Equine melanocytic neoplasm (EMN) is a cutaneous neoplasm and is mostly observed in aged grey horses. This preliminary study aimed to identify potential proteins to differentiate normal, mild and severe EMN from serum proteomic profiling. Serum samples were collected from 25 grey horses [...] Read more.
Equine melanocytic neoplasm (EMN) is a cutaneous neoplasm and is mostly observed in aged grey horses. This preliminary study aimed to identify potential proteins to differentiate normal, mild and severe EMN from serum proteomic profiling. Serum samples were collected from 25 grey horses assigned to three groups: normal (free of EMN; n = 10), mild (n = 6) and severe EMN (n = 9). To explore the differences in proteins between groups, proteomic profiling and analysis were employed. Accordingly, 8241 annotated proteins out of 8725 total proteins were compared between normal and EMN groups and inspected based on differentially expressed proteins (DEPs). Through DEP analysis, 95 significant DEPs differed between normal and EMN groups. Among these DEPs, 41 significant proteins were categorised according to protein functions. Based on 41 significant proteins, 10 were involved in metabolism and 31 in non-metabolism. Interestingly, phospholipid phosphatase6 (PLPP6) and ATPase subunit alpha (Na+/K+-ATPase) were considered as potential proteins uniquely expressed in mild EMN and related to lipid and energy metabolism, respectively. Non-metabolism-related proteins (BRCA1, phosphorylase B kinase regulatory subunit: PHKA1, tyrosine-protein kinase receptor: ALK and rho-associated protein kinase: ROCK1) correlated to melanoma development differed among all groups. The results of our study provide a foundation for early EMN biomonitoring and prevention. Full article
(This article belongs to the Special Issue Advances in Equine Metabolomics)
Show Figures

Figure 1

Back to TopTop