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  • Review
  • Open Access

Tannins: A Promising Antidote to Mitigate the Harmful Effects of Aflatoxin B1 to Animals

  • Wenhao Sun,
  • Ruiqi Dong,
  • Guoxia Wang,
  • Bing Chen,
  • Zhi Weng Josiah Poon,
  • Jiun-Yan Loh,
  • Xifeng Zhu,
  • Junming Cao and
  • Kai Peng
Toxins2026, 18(1), 15;https://doi.org/10.3390/toxins18010015 
(registering DOI)

25 December 2025

Aflatoxin B1 (AFB1), a major metabolite of aflatoxin, is a highly toxic carcinogen. It frequently contaminates feed due to improper storage of feed ingredients such as corn and peanut meal, with the contamination risk further escalating alongside the...

  • Article
  • Open Access

Aflatoxin Mixture-Driven Intrahepatic Cholangiocarcinoma in Rats Involving G1/S Checkpoint Dysregulation

  • Vinícius Menezes Braga,
  • Paulo Henrique Fernandes Pereira,
  • Letícia de Araujo Apolinario,
  • Deisy Mara Silva Longo,
  • Leandra Naira Zambelli Ramalho,
  • Sher Ali,
  • Carlos Augusto Fernandes de Oliveira and
  • Fernando Silva Ramalho
Toxins2026, 18(1), 14;https://doi.org/10.3390/toxins18010014 
(registering DOI)

25 December 2025

Aflatoxins (AFs) are potent hepatotropic mycotoxins—AFB1 being the best-characterized—yet their ability to induce intrahepatic cholangiocarcinoma (iCCA) remains underexplored. Male Wistar rats received vehicle (controls; n = 5) or an AFB1...

  • Article
  • Open Access

Systematic Approach to Reducing Errors in Deoxynivalenol Quantification: Insights from Bulk Wheat Sampling and Sample Preparation

  • Li Li,
  • Bingjie Li,
  • Jin Ye,
  • Di Cai,
  • Yu Wu,
  • Peng Li,
  • Bing Zhang,
  • Jie Wang,
  • Xiujuan Li and
  • Yi Shao
  • + 1 author

24 December 2025

Accurate quantification of Deoxynovalienol (DON) in wheat is critical for food safety, but current methods suffer from poor reproducibility due to inconsistent operational parameters across the sampling and analysis workflow. To address this issue, t...

  • Article
  • Open Access

24 December 2025

The consumption of nuts is widespread globally and constitutes a significant component of the human diet due to its nutritional value. However, the presence of mycotoxins in food products, including nuts, is a global public health concern. Mycotoxins...

  • Article
  • Open Access

Efficient Expression of Lactone Hydrolase Cr2zen for Scalable Zearalenone Degradation in Pichia pastoris

  • Mukhtar Ahmad,
  • Hui Wang,
  • Xiaomeng Liu,
  • Shounan Wang,
  • Tie Yin,
  • Kun Deng,
  • Caixia Lu,
  • Xiaolin Zhang and
  • Wei Jiang

23 December 2025

Zearalenone (ZEN) is a thermostable, lipophilic, non-steroidal estrogenic mycotoxin produced by Fusarium spp. that persistently contaminates food and feed. Its strong estrogenic activity and resistance to conventional detoxification strategies pose s...

  • Article
  • Open Access
88 Views
19 Pages

Plasma Metabolomics Reveals Systemic Metabolic Remodeling in Early-Lactation Dairy Cows Fed a Fusarium-Contaminated Diet and Supplemented with a Mycotoxin-Deactivating Product

  • Gabriele Rocchetti,
  • Alessandro Catellani,
  • Marco Lapris,
  • Nicole Reisinger,
  • Johannes Faas,
  • Ignacio Artavia,
  • Silvia Labudova,
  • Erminio Trevisi and
  • Antonio Gallo
Toxins2026, 18(1), 9;https://doi.org/10.3390/toxins18010009 
(registering DOI)

22 December 2025

This study investigated the systemic metabolic effects of feeding a Fusarium-contaminated diet to early-lactation Holstein cows, with or without a mycotoxin-deactivating product (MDP; Mycofix® Plus, BIOMIN Holding GmbH, Tulln, Austria). Thirty co...

  • Review
  • Open Access
56 Views
9 Pages

22 December 2025

This scoping review aimed to summarize the current literature on the etiological and pathophysiological mechanisms associated with the development of retrograde cricopharyngeus dysfunction (R-CPD) through a PRISMA literature search. According to the...

  • Article
  • Open Access
70 Views
12 Pages

22 December 2025

α-Zearalenol (α-ZOL), the primary metabolite of zearalenone (ZEN), is a prevalent mycotoxin in agricultural products (e.g., corn, wheat) and poses health risks due to its toxicity. However, strategies to mitigate its toxicity are needed....

  • Article
  • Open Access
172 Views
29 Pages

Probiotic Supplementation in Chronic Kidney Disease: Outcomes on Uremic Toxins, Inflammation, and Vascular Calcification from Experimental and Clinical Models

  • Teresa Obrero,
  • María Victoria Pendón-Ruiz de Mier,
  • Jose E. Gordillo-Arnaud,
  • María José Jiménez Moral,
  • Victoria Vidal,
  • Fátima Guerrero,
  • Andrés Carmona,
  • María Encarnación Rodríguez-Ortiz,
  • Ana Isabel Torralbo and
  • Raquel Ojeda
  • + 13 authors
Toxins2026, 18(1), 6;https://doi.org/10.3390/toxins18010006 
(registering DOI)

20 December 2025

Chronic kidney disease (CKD) is associated with gut microbiota alterations that contribute to increased inflammation and the generation of uremic toxins and may worsen the disease progression. While probiotics may improve the pro-inflammatory cytokin...

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Toxins - ISSN 2072-6651