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Future Pharmacology, Volume 3, Issue 4

December 2023 - 17 articles

Cover Story: Malaria, caused by Plasmodium, remains a global challenge, and efforts to reduce its prevalence have plateaued since 2018. Looming drug resistance of the most dangerous species Plasmodium falciparum against artemisinin and its derivates calls for novel antimalarial agents. During its life cycle, the parasite passes through mosquitoes, infects warm-blooded mammalian host’s liver cells, and then invades red blood cells, before developing again to sexual forms which are then ingested by mosquitoes. All these steps require finely orchestrated regulatory mechanisms, and in Plasmodium, these comprise histone modifications and ApiAP2 transcription factors, both of which offer potential drug targets. This study reviews epigenetic mechanisms and transcription factors in P. falciparum, exploring their potential for antimalarial drug development. View this paper
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Articles (17)

  • Review
  • Open Access
10 Citations
15,117 Views
28 Pages

Therapeutic Use of Palmitoylethanolamide as an Anti-Inflammatory and Immunomodulator

  • Maria Clara Inácio de Sá and
  • Marina Gomes Miranda Castor

Palmitoylethanolamine (PEA) is an endocannabinoid-like compound first encountered within the lipid fractions of specific foods and has intrigued researchers since the 1950s due to its therapeutic effects. This survey aims to explore the therapeutic p...

  • Review
  • Open Access
3,010 Views
13 Pages

Feline population control remains a concern as to whether it is intended for the short- or long-term. Induced sterilization of felids is critical in the case of feral, free-roaming cats, or the management of wild populations in Zoos or sanctuaries. T...

  • Review
  • Open Access
2 Citations
4,782 Views
13 Pages

Overview of Pharmacological Therapies for Diffuse Tenosynovial Giant Cell Tumor

  • Antonia Stamatiou,
  • Tu Nguyen-Ngoc,
  • Laureline Wetterwald,
  • Ana-Maria Dolcan,
  • Giovanni Dei Tos,
  • Stephane Cherix,
  • Patrick Omoumi and
  • Antonia Digklia

Tenosynovial giant cell tumor (TGCT) is a rare and locally aggressive benign tumor arising from the synovium of joints, bursae, and tendon sheaths. It is classified into localized (L-TGCT) and diffuse (D-TGCT) forms based on the extent of involvement...

  • Article
  • Open Access
2,156 Views
10 Pages

Evaluations of NSAIDs and Opioids as Analgesics in Pediatric Oncology

  • Eduardo Ladeia Leal,
  • Paulo Caleb Júnior Lima Santos,
  • Thuane Sales Gonçalves,
  • Mariana Martins Gonzaga do Nascimento,
  • Fábio Cardoso Cruz,
  • Flávia Borelli Gomes do Nascimento and
  • Carolina Paula Jesus Kasa

As one of the leading causes of death in childhood, cancer also causes discomfort to pediatric patients. Even with guidelines for pain management, more than half of hospitalized children have intense and unrelieved pain. The present work aims to desc...

  • Case Report
  • Open Access
5,028 Views
8 Pages

Could Cariprazine Be a Possible Choice for High Functioning Autism? A Case Report

  • Andrea Miuli,
  • Carlotta Marrangone,
  • Ornella Di Marco,
  • Arianna Pasino,
  • Gianfranco Stigliano,
  • Alessio Mosca,
  • Mauro Pettorruso,
  • Fabrizio Schifano and
  • Giovanni Martinotti

This case report was conducted by searching for the following keywords on PubMed: High Functioning Autism, Autism Spectrum Disorder, cariprazine, aripiprazole, partial agonist antipsychotic, DRD2/DRD3. High Functioning Autism (HFA) is a neurodevelopm...

  • Review
  • Open Access
30 Citations
12,759 Views
31 Pages

Unlocking the Therapeutic Potential of Medicinal Plants for Alzheimer’s Disease: Preclinical to Clinical Trial Insights

  • Kushagra Nagori,
  • Kartik T. Nakhate,
  • Krishna Yadav,
  • Ajazuddin and
  • Madhulika Pradhan

Alzheimer’s disease (AD) is a progressive, multifactorial, and unremitting neurodegenerative disease characterized by memory loss, personality changes, and cognitive impairment. It has become more prevalent in recent years. Therefore, understan...

  • Article
  • Open Access
2 Citations
1,644 Views
15 Pages

In recent decades, the roles of tacrolimus and mycophenolate mofetil (MMF) in hypertension have been under discussion. However, the question of whether there are sex-specific responses to these agents has not received enough attention. Aim: To evalua...

  • Review
  • Open Access
1 Citations
2,832 Views
16 Pages

Plasmodial Transcription Factors and Chromatin Modifiers as Drug Targets

  • Luisa Fernanda Ortega Sepulveda,
  • Gabriela Mendes de Oliveira,
  • Elaine Hellen Nunes Chagas,
  • Nele Wild,
  • Franciarli Silva da Paz,
  • Carsten Wrenger and
  • Gerhard Wunderlich

The complex life cycle of the malaria parasite Plasmodium requires the parasite to adequately adapt to different conditions. For this reason, Plasmodium strictly controls its gene expression, and given its evolutionary distance from the human host, t...

  • Review
  • Open Access
5 Citations
4,862 Views
12 Pages

Considerations of Nystatin Roll in Oral Candidiasis Scenario and the COVID-19 Pandemic—A Review

  • Michelle Maria Gonçalves Barão de Aguiar,
  • Renata Miliani Martinez,
  • André Rolim Baby and
  • Cristina Helena dos Reis Serra

Oral candidiasis is an opportunistic infection usually related to predisposing factors. Oral manifestations in patients affected by COVID-19 have been reported, as the oral mucosa is the gateway to this viral infection. Xerostomia, as well as other o...

  • Article
  • Open Access
3 Citations
2,338 Views
15 Pages

Methotrexate (MTX) is the cornerstone of therapy in the treatment of rheumatoid arthritis (RA). However, its efficacy and toxicity are variable and remain unpredictable. Interindividual variation in the metabolism of MTX by the enzyme folyl polygluta...

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Future Pharmacol. - ISSN 2673-9879