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Organics, Volume 6, Issue 2

June 2025 - 15 articles

Cover Story: Aniline is one of the most representative molecules of the intrinsic polarity of chemistry: the first artificial dyes were obtained from it, with a decisive push towards the industrial revolution but also with negative repercussions on the health of workers. It has exerted a great influence on fashion and art, becoming the symbol of an era of great innovations, but also of contradictions and social conflicts. Today, it still plays a key role in various sectors, including the production of inks, the synthesis of drugs, and the design of smart textiles. Its history and its chemistry are extremely significant for a broad-ranging educational approach. View this paper
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Articles (15)

  • Article
  • Open Access
2 Citations
1,131 Views
13 Pages

Small Deviations in Geometries Affect Detonation Velocities and Pressures of Nitroaromatic Molecules

  • Danijela S. Kretić,
  • Marija I. Maslarević and
  • Dušan Ž. Veljković

9 April 2025

Understanding the factors that affect the detonation performance of high-energy molecules (HEMs) is crucial for the design of novel explosives and fuels with desirable characteristics. While molecular factors, such as the presence of specific functio...

  • Review
  • Open Access
6 Citations
10,360 Views
49 Pages

An Overview of Quinolones as Potential Drugs: Synthesis, Reactivity and Biological Activities

  • Ayoub El-mrabet,
  • Amal Haoudi,
  • Youssef Kandri-Rodi and
  • Ahmed Mazzah

3 April 2025

Quinolones represent one of the largest classes of synthetic antibiotics used in both human and veterinary medicine. Since the discovery of nalidixic acid, a substantial body of research has been carried out on quinolones, resulting in the synthesis...

  • Article
  • Open Access
2,091 Views
11 Pages

Synthesis of Indole-Based Derivatives Containing Ammonium Salts, Diamines and Aminoureas for Organocatalysis

  • Marcello Casertano,
  • Brian G. Kelly,
  • Malachi W. Gillick-Healy,
  • Paolo Grieco and
  • Mauro F. A. Adamo

2 April 2025

Indole heterocycles have an established reactivity, and these compounds are H-bond donors via a peculiar non-basic NH. However, the indole core has been scarcely employed in organocatalysis, with only a few examples relevant to electrophilic halogena...

  • Article
  • Open Access
1,221 Views
9 Pages

Optimized Synthesis of Dinitrochalcones via Ultrasonic Bath in a Cyclohexane–Methanol Solvent System

  • Alam Yair Hidalgo,
  • Quirino Torres-Sauret,
  • Carlos Ernesto Lobato-García,
  • Erika Madeleyne Ramos-Rivera,
  • Luis Fernando Roa de la Fuente,
  • Abraham Gómez-Rivera,
  • Miguel Ángel Vilchis-Reyes,
  • Erika Alarcón-Matus,
  • Oswaldo Hernández-Abreu and
  • Nancy Romero-Ceronio

1 April 2025

This study describes the efficient synthesis of five dinitrochalcones (DNCHs) using an ultrasonic bath as an unconventional method to improve reaction yields and reduce reaction times. The Claisen–Schmidt condensation of nitroacetophenones and...

  • Article
  • Open Access
1 Citations
2,821 Views
26 Pages

Synthesis and In Silico Evaluation of GABA, Pregabalin and Baclofen N-Heterocyclic Analogues as GABAB Receptor Agonists

  • Zuleyma Martínez-Campos,
  • Luis Eduardo Hernandez-Dominguez,
  • Fatima Romero-Rivera,
  • Diana López-López,
  • María Vicky Corona-González,
  • Susana T. López-Cortina,
  • Francisco José Palacios-Can,
  • Rodrigo Said Razo-Hernández and
  • Mario Fernández-Zertuche

24 March 2025

γ-amino butyric acid (GABA) is an inhibitory neurotransmitter whose deficiency has been associated with various neurological disorders. However, its low liposolubility limits its use as a supplement. Thus, multiple investigations have focused o...

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Organics - ISSN 2673-401X