Abstract
Deep eutectic solvents (DESs) are emerging as efficient, green, low-toxicity solvents in the field of natural product extraction and separation. To systematically understand the development trend and research hotspots in this area, this paper, based on databases such as Web of Science, retrieved the relevant literature from 2017 to 2026. Using bibliometric and visualization analysis methods, it conducted an analysis of dimensions such as annual publication volume, research fields, country/institution distribution, core authors, highly cited papers/authors, keyword co-occurrence, and clustering. The results show that the number of publications in this field has continued to increase over the past decade, with China being the main contributor; the research hotspots focus on the green extraction processes of DESs, ultrasonic-/microwave-assisted extraction, efficient separation of active components such as flavonoids/polyphenols, as well as the biological activity evaluation of the extracts and mechanism exploration. This study comprehensively reveals the development trend, core forces, and research hotspots of the field, providing references and directions for the subsequent development of new DESs with high efficiency, safety, economy, and environmental friendliness, as well as green preparation technologies for natural products.