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Clocks & Sleep, Volume 4, Issue 2

June 2022 - 8 articles

Cover Story: Caffeine is the most widely used stimulant on earth. It is generally assumed that consumption of a single dose of caffeine influences sleep only for the first 24 hours. This study aimed to record sleep and simultaneously perform electrophysiology in the lateral hypothalamus for at least 2 days after applying a single dose of caffeine. Recordings were performed in constant darkness as light and caffeine are known to interact in their effects on sleep and circadian rhythms. The data show that electroencephalogram theta (6–9 Hz) activity was increased for 48 hours, particularly in REM sleep. Neuronal activity in the lateral hypothalamus was increased in parallel. The data suggest that caffeine influences the brain longer than previously acknowledged, particularly under low light level conditions. View this paper
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Articles (8)

  • Conference Report
  • Open Access
2,866 Views
21 Pages

The 2021 meeting in Solothurn provided evidence-based education to advance the science and clinical practice of sleep medicine and sleep physiology, disseminates cutting-edge sleep and circadian research, promotes the translation of basic science int...

  • Review
  • Open Access
7 Citations
5,173 Views
13 Pages

Neuroimaging in the Rare Sleep Disorder of Kleine–Levin Syndrome: A Systematic Review

  • Juan Fernando Ortiz,
  • Jennifer M. Argudo,
  • Mario Yépez,
  • Juan Andrés Moncayo,
  • Hyder Tamton,
  • Alex S. Aguirre,
  • Ghanshyam Patel,
  • Meghdeep Sen,
  • Ayushi Mistry and
  • Ray Yuen
  • + 3 authors

Kleine–Levin syndrome (KLS) is characterized by episodes of hypersomnia. Additionally, these patients can present with hyperphagia, hypersexuality, abnormal behavior, and cognitive dysfunction. Functional neuroimaging studies such as fMRI-BOLD,...

  • Article
  • Open Access
3,193 Views
10 Pages

Effect of Modified Yukmijihwang-Tang on Sleep Quality in the Rat

  • SunYoung Lee,
  • Hun-Soo Lee,
  • Minsook Ye,
  • Min-A Kim,
  • Hwajung Kang,
  • Sung Ja Rhie,
  • Mi Young Lee,
  • In Chul Jung,
  • In-Cheol Kang and
  • Insop Shim

Many plants have been used in Korean medicine for treating insomnia. However, scientific evidence for their sedative activity has not been fully investigated. Thus, this study was carried out to investigate the sedative effects of the extracts of med...

  • Article
  • Open Access
5 Citations
8,201 Views
17 Pages

Background: Caffeine is a central nervous system stimulant that influences both the sleep–wake cycle and the circadian clock and is known to influence neuronal activity in the lateral hypothalamus, an important area involved in sleep–wake...

  • Review
  • Open Access
17 Citations
4,299 Views
20 Pages

The objectives of this empirical study are to describe and discuss the current literature available on the relationship between excessive daytime sleepiness (EDS) and the socioeconomic position (SEP) as well as to provide recommendations for consider...

  • Article
  • Open Access
5 Citations
7,050 Views
10 Pages

Lucid dreaming offers the chance to investigate dreams from within a dream and by real-time dialogue between experimenters and dreamers during REM sleep. This state of consciousness opens a new experimental venue for dream research. However, laborato...

  • Systematic Review
  • Open Access
12 Citations
8,020 Views
11 Pages

Respiratory Muscle Training in Patients with Obstructive Sleep Apnoea: A Systematic Review and Meta-Analysis

  • Rodrigo Torres-Castro,
  • Lilian Solis-Navarro,
  • Homero Puppo,
  • Victoria Alcaraz-Serrano,
  • Luis Vasconcello-Castillo,
  • Jordi Vilaró and
  • Roberto Vera-Uribe

Background: Effective treatments for obstructive sleep apnoea (OSA) include positive pressure, weight loss, oral appliances, surgery, and exercise. Although the involvement of the respiratory muscles in OSA is evident, the effect of training them to...

  • Article
  • Open Access
2 Citations
3,970 Views
11 Pages

Direct Effects of Light on Sleep under Ultradian Light-Dark Cycles Depend on Circadian Time and Pulses Duration

  • Fanny Fuchs,
  • Ludivine Robin-Choteau,
  • Laurence Hugueny,
  • Dominique Ciocca and
  • Patrice Bourgin

Ultradian light–dark cycles in rodents are a precious tool to study the direct effects of repeated light exposures on sleep, in order to better understand the underlying mechanisms. This study aims to precisely evaluate the effects of light and...

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Clocks & Sleep - ISSN 2624-5175