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Clocks & Sleep, Volume 7, Issue 3

September 2025 - 23 articles

Cover Story: Individuals with neurodevelopmental disorders (NDDs) are vulnerable to sleep disruption and light exposure at night, but it remains unclear whether the adverse effects stem from light itself or from circadian misalignment. In the Cntnap2 KO model, the effects of dim light at night (DLaN) and of an ultradian T7 cycle (3.5 h light/3.5 h dark) were compared. DLaN exacerbated social deficits and repetitive grooming and evoked cFos expression in the amygdala. The T7 cycle modestly reduced rhythm strength without worsening these behaviors or neural markers. These results suggest that circadian disruption, not light exposure alone, drives the adverse effects of nighttime light. Our findings highlight circadian stability as a protective factor and suggest interventions targeting circadian alignment may mitigate behavioral vulnerability in NDDs. View this paper
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Articles (23)

  • Article
  • Open Access
1,182 Views
21 Pages

Sleepiness and Fatigue as Consequences of Cumulative Sleep Restriction: Insights from Fine-Grained Subjective Measures and Skin Temperature in the Field

  • Vaida T. R. Verhoef,
  • Karin C. H. J. Smolders,
  • Geert Peeters,
  • Sebastiaan Overeem and
  • Yvonne A. W. de Kort

Diagnosis and monitoring of daytime sleepiness remain challenging and are strongly reliant on subjective assessments. To revisit common monitoring tools and explore new assessment modalities, we investigated the response of daily and momentary subjec...

  • Review
  • Open Access
1,351 Views
14 Pages

Attention Deficit Hyperactivity Disorder (ADHD) is a prevalent disorder in the pediatric population. Furthermore, there appears to be a special relationship between ADHD and Restless Legs Syndrome (RLS). The objective of this review was therefore to...

  • Article
  • Open Access
1,422 Views
12 Pages

Sleep in intensive care unit (ICU) patients is frequently disrupted, which may adversely affect their overall health and recovery. Despite the implementation of various strategies to promote sleep, accurately assessing its quality remains complex. Th...

  • Article
  • Open Access
1,177 Views
17 Pages

Dissociating the Effects of Light at Night from Circadian Misalignment in a Neurodevelopmental Disorder Mouse Model Using Ultradian Light–Dark Cycles

  • Sophia Anne Marie B. Villanueva,
  • Huei-Bin Wang,
  • Kyle Nguyen-Ngo,
  • Caihan Tony Chen,
  • Gemma Stark,
  • Gene D. Block,
  • Cristina A. Ghiani and
  • Christopher S. Colwell

Individuals with neurodevelopmental disorders (NDDs) often experience sleep disturbances and are frequently exposed to light during nighttime hours. Our previous studies using the Contactin-associated protein-like 2 (Cntnap2) knockout (KO) mouse mode...

  • Review
  • Open Access
1 Citations
3,729 Views
26 Pages

Sleep, Physical Activity, and Executive Functions in Students: A Narrative Review

  • Giulia Belluardo,
  • Debora Meneo,
  • Silvia Cerolini,
  • Chiara Baglioni and
  • Paola De Bartolo

The school and university periods represent a critical phase in individuals’ cognitive, emotional, and behavioural development. Numerous lifestyle factors can influence executive functions and high-level cognitive processes crucial for learning...

  • Review
  • Open Access
1,552 Views
14 Pages

Concussion Disrupts Sleep in Adolescents: A Systematic Review and Meta-Analysis

  • Suleyman Noordeen,
  • Poh Wang,
  • Anna E. Strazda,
  • Eszter Sara Arany,
  • Mehmet Ergisi,
  • Linghui Janice Yeo,
  • Rebeka Popovic,
  • Abinayan Mahendran,
  • Mikail Khawaja and
  • Kritika Grover
  • + 5 authors

Concussions significantly impact sleep quality among adolescents. Despite increasing recognition of these effects, the complex relationship between adolescent concussions and sleep disturbances is still not fully understood and presents mixed finding...

  • Article
  • Open Access
1,828 Views
14 Pages

The Acute Effects of Morning Bright Light on the Human White Adipose Tissue Transcriptome: Exploratory Post Hoc Analysis

  • Anhui Wang,
  • Jeroen Vreijling,
  • Aldo Jongejan,
  • Valentina S. Rumanova,
  • Ruth I. Versteeg,
  • Andries Kalsbeek,
  • Mireille J. Serlie,
  • Susanne E. la Fleur,
  • Peter H. Bisschop and
  • Frank Baas
  • + 1 author

The circadian rhythm of the central brain clock in the suprachiasmatic nucleus (SCN) is synchronized by light. White adipose tissue (WAT) is one of the metabolic endocrine organs containing a molecular clock, and it is synchronized by the SCN. Excess...

  • Article
  • Open Access
999 Views
19 Pages

Sleep Quality and Patient Activation in Chronic Disease: A Cross-Sectional Mediation Analysis

  • Christian J. Wiedermann,
  • Verena Barbieri,
  • Stefano Lombardo,
  • Timon Gärtner,
  • Klaus Eisendle,
  • Giuliano Piccoliori,
  • Adolf Engl and
  • Dietmar Ausserhofer

Patient activation enhances self-management of chronic illnesses, and sleep quality is vital for health. The link between activation and sleep quality and the mediating role of chronic diseases remain underexplored. This study examined the associatio...

  • Case Report
  • Open Access
1,135 Views
9 Pages

Hypersomnia may be classified as primary or secondary, with secondary hypersomnia arising from a variety of underlying causes. Thus, according to ICSD3-TR classification, the diagnosis of idiopathic hypersomnia (IH) is established based on (1) excess...

  • Article
  • Open Access
642 Views
13 Pages

Polygraphic Results in High-Risk Infants Aged Under 3 Months

  • Daniel Zenteno,
  • Gerardo Torres-Puebla,
  • Camila Sánchez,
  • Rocío Gutiérrez,
  • María José Elso and
  • Pablo E. Brockmann

This study described and analyzed the results of cardiorespiratory polygraphic studies in infants under three months who were hospitalized and monitored due to suspected apneas. Methods: Cross-sectional study. Patients aged <3 months hospitalized...

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Clocks & Sleep - ISSN 2624-5175