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Clocks & Sleep, Volume 7, Issue 4

2025 December - 19 articles

Cover Story: Sleep depends on coordinated activity within subcortical networks, yet how interactions among these regions shape human sleep remains unclear. This study investigates the crosstalk (or effective connectivity) between the locus coeruleus and hypothalamic subregions in wakefulness and relates these dynamics to sleep EEG features. Using 7T fMRI and laboratory sleep recordings, the authors first find strong bidirectional influences between these areas, consistent with animal research. They also identify age-related reductions in hypothalamus-to-locus coeruleus connectivity and show that, in late middle-aged adults (aged 50 to 70 years), stronger connectivity predicts lower REM theta and other low-frequency powers. These results highlight that subcortical communication contributes to sleep regulation and its changes with age. View this paper
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Articles (19)

  • Review
  • Open Access
792 Views
11 Pages

This paper reviews existing research on infant mattress design to promote safe and comfortable sleep and proposes evidence-based design recommendations. Focusing on safety related to Sudden Unexpected Infant Death (SUID) and comfort associated with i...

  • Review
  • Open Access
1 Citations
2,050 Views
12 Pages

Effects of Digital Cognitive Behavioral Therapy for Insomnia on Self-Reported Sleep Parameters: Systematic Review and Meta-Analysis

  • Ingrid Porto Araújo Leite,
  • Viviane Akemi Kakazu,
  • Lucca Andrade Teixeira de Carvalho,
  • Sergio Tufik and
  • Gabriel Natan Pires

Digital Cognitive Behavioral Therapy for Insomnia (dCBT-I) is an effective alternative to therapist-delivered CBT-I. However, there is a lack of meta-analyses assessing its effects on other sleep-related outcomes. We aimed to conduct a meta-analysis...

  • Article
  • Open Access
1,111 Views
17 Pages

Anticipation of Stress and Relaxation Dynamically Impacts Sleep

  • Sandrine Baselgia,
  • Jonas Beck and
  • Björn Rasch

Anticipation of stressful events can impair sleep quality. In a recent study, we reported that anticipating a stressful task before a nap led to negative changes in sleep parameters, particularly at the end of the nap. In our previous study, we compa...

  • Article
  • Open Access
841 Views
22 Pages

Estimation of the Circadian Phase Difference in Weekend Sleep and Further Evidence for Our Failure to Sleep More on Weekends to Catch Up on Lost Sleep

  • Arcady A. Putilov,
  • Evgeniy G. Verevkin,
  • Dmitry S. Sveshnikov,
  • Zarina V. Bakaeva,
  • Elena B. Yakunina,
  • Olga V. Mankaeva,
  • Vladimir I. Torshin,
  • Elena A. Trutneva,
  • Michael M. Lapkin and
  • Vladimir B. Dorokhov
  • + 8 authors

The circadian phase difference between morning and evening types is a fundamental aspect of chronotype. However, results of categorizations into chronotypes based on reported sleep times show low concordance with those based on measurements of the ho...

  • Review
  • Open Access
2 Citations
3,684 Views
18 Pages

Sleep is essential for child development, influencing cognition, emotional regulation, behavior, and physical health. Recent studies increasingly frame sleep as both a key developmental process and a modifiable factor shaped by, and shaping environme...

  • Article
  • Open Access
1,042 Views
11 Pages

Objective: An association between sleep apnea and various urological symptoms has been reported in the literature. Therefore, the aim of this study is to analyze sex-related differences in the association between sleep apnea und subsequent urinary in...

  • Article
  • Open Access
2,058 Views
15 Pages

Sleep and Psychosocial Risk Factors Associated with Social Jet Lag and Sleep Duration Among Colombian University Students

  • Andrés Camargo,
  • Leandro P. Casiraghi,
  • Diego A. Golombek,
  • Edith Villalobos,
  • Viviana González,
  • Carlos Orozco,
  • Elena Jiménez,
  • Danny Sanjuanelo,
  • Oscar Pianeta and
  • Rafael Vargas

Undergraduate students and healthcare professionals often experience irregular sleep patterns, social jet lag (SJL), and rotating shifts that affect their performance. This study examined the association between SJL, sleep duration, and psychosocial...

  • Review
  • Open Access
1,824 Views
18 Pages

Burnout is increasingly recognized as both a psychosocial and a chronobiological disorder characterized by endocrine dysregulation and circadian disruption. It arises from chronic occupational stress and manifests through psychological, physical, and...

  • Review
  • Open Access
3,797 Views
13 Pages

Critically ill patients are predisposed to developing cognitive dysfunction, excessive daytime sleepiness (EDS), and fatigue during their stay in the intensive care unit (ICU). Modafinil, a wakefulness-promoting agent, has demonstrated potential bene...

  • Article
  • Open Access
949 Views
13 Pages

Psychometric Validation and Arabic Translation of the 11-Item Circadian Type Inventory (CTI-11A) Among Shift Workers

  • Sara Ahmed Mansoor AlBuhmaid,
  • Muneera Jasim Al-Rumaihi,
  • Mohammed Adel M Albalawi,
  • Ahmed Abdullatif Ahmed Almufarrij,
  • Waqar Husain and
  • Haitham Jahrami

Circadian rhythm disruptions from shiftwork impact sleep quality and work performance, yet validated tools to assess circadian preferences in Arabic-speaking populations are scarce. This study aimed to translate and validate the 11-item Circadian Typ...

  • Article
  • Open Access
1,393 Views
15 Pages

Influence of Maternal Working Hours on Children’s Sleep: A Preliminary Study on Disparities Between Day and Night Shifts

  • Patrícia Andrade Nehme,
  • Jefferson Santos,
  • Ana Amélia Benedito-Silva,
  • José Cipolla-Neto and
  • Claudia R. C. Moreno

Background: Shift work necessitates alterations in daily routines, which can be detrimental to workers’ health and may also influence the activity and rest patterns of their children. Aim: The aim of this study was to evaluate the concordance b...

  • Communication
  • Open Access
1,810 Views
10 Pages

Short sleep duration (≤6 h) is a public health concern linked to cardiometabolic disease and premature mortality. However, persistent disparities across sociodemographic, psychosocial, and structural domains remain underexplored in recent national...

  • Article
  • Open Access
1,152 Views
15 Pages

Cross-Sectional Analysis of Sleep Quality and Vascular Health in Shift- and Day-Working Nurses

  • Gleb Saharov,
  • Barbara Salti,
  • Maram Bareya,
  • Anat Keren-Politansky,
  • Yona Nadir and
  • Tamar Shochat

Sleep disturbances and shift work are associated with increased cardiovascular risk, possibly through disruptions in endothelial and hemostatic function. While prior studies link acute sleep deprivation to vascular dysfunction, the impact of chronic...

  • Article
  • Open Access
1,880 Views
17 Pages

Academic performance in adolescence is influenced by both cognitive capacity and physiological factors such as sleepiness. However, the interaction between these dimensions remains understudied. This pilot study examined whether daytime sleepiness mo...

  • Article
  • Open Access
1 Citations
2,305 Views
13 Pages

Self-Reported Insomnia and Poor Sleep Quality Are Associated with Self-Reported Cognitive Changes in Older Adults

  • Julia Glueck,
  • Celina Pluim McDowell,
  • Yakeel T. Quiroz,
  • Alice Cronin-Golomb and
  • Jeanne F. Duffy

Older adults are vulnerable to changes in sleep with age. Poor sleep quality is associated with self-reported cognitive changes, which can occur before the onset of objective cognitive decline associated with Mild Cognitive Impairment and Alzheimer&r...

  • Article
  • Open Access
4,933 Views
20 Pages

Ambient temperature and thermoregulation influence sleep quality. This study investigated the effects of a temperature-controlled mattress cover on sleep and perceptual outcomes in healthy adults. In a randomised, counterbalanced, crossover design, 3...

  • Article
  • Open Access
1,481 Views
15 Pages

Reporter-Mediated Evaluation of the Circadian Oscillations of SNAIL Across In Vitro Models

  • Kaitlyn Chhe,
  • Bhavna Kalyanaraman,
  • Sophie A. Spielberger,
  • Hui-Hsien Lin,
  • Stephanie R. Taylor and
  • Michelle E. Farkas

The protein SNAIL has been widely studied for its roles in promoting cancer invasion and resistance to apoptosis. There are multiple contributors to its expression, including self- and circadian regulation, and it has been posited that SNAIL oscillat...

  • Article
  • Open Access
1,383 Views
22 Pages

The Crosstalk Between the Anterior Hypothalamus and the Locus Coeruleus During Wakefulness Is Associated with Low-Frequency Oscillations Power During Sleep

  • Nasrin Mortazavi,
  • Puneet Talwar,
  • Ekaterina Koshmanova,
  • Roya Sharifpour,
  • Elise Beckers,
  • Ilenia Paparella,
  • Fermin Balda,
  • Christine Bastin,
  • Fabienne Collette and
  • Gilles Vandewalle
  • + 3 authors

Animal studies show that sleep regulation depends on subcortical networks, but whether the connectivity between subcortical areas contributes to human sleep variability remains unclear. We investigated whether the effective connectivity between the L...

  • Article
  • Open Access
1,394 Views
13 Pages

Exploring the Cross-Sectional Association Between Hypothyroidism and Circadian Syndrome: Insights from NHANES 2007–2012

  • Ahmed Arabi,
  • Humam Emad Rajha,
  • Osama Alkeilani,
  • Ahmad Hamdan,
  • Dima Nasrallah and
  • Giridhara R. Babu

Background: Circadian Syndrome (CircS) encompasses a range of cardiometabolic risk factors that contribute to an increased susceptibility to cardiovascular diseases and type 2 diabetes. Understanding the factors that underpin CircS is essential. This...

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Clocks & Sleep - ISSN 2624-5175