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  • Advances in Respiratory Medicine is published by MDPI from Volume 90 Issue 4 (2022). Previous articles were published by another publisher in Open Access under a CC-BY (or CC-BY-NC-ND) licence, and they are hosted by MDPI on mdpi.com as a courtesy and upon agreement with Via Medica.
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8 January 2015

5 Pages

Leflunomide-Induced Acute Interstitial Pneumonia in a Patient Treated for Rheumatoid Arthritis

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1
Department of Internal Medicine, Pneumonology and Allergology, Medical University of Warsaw, 02-097 Warszawa, Poland
2
Department of Pathology, Medical University of Warsaw, Warsaw, Poland
3
Department of Pathology, Institute for Tuberculosis and Lung Diseases, Warsaw, Poland
*
Author to whom correspondence should be addressed.
Adv. Respir. Med.2015, 83(1), 50-54;https://doi.org/10.5603/PiAP.2015.0007
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Abstract

Leflunomide is a disease-modifying anti-rheumatic drug that is used in patients with rheumatoid arthritis (RA), who do not respond well to standard RA treatment. Leflunomide therapy may, however, be related with significant pulmonary complications in predisposed individuals. We present a patient with RA treated with leflunomide, in whom leflunomide lung injury had a fatal outcome. Potential risk factors for pulmonary complications of leflunomide treatment and the management of patients with leflunomide lung injury are discussed.

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