Analysis of the Cytotoxic Effects of Achillea millefolium L. Extracts on MCF7 Cell Line †
Department of Pharmacognosy, Faculty of Pharmacy, Erciyes University, Kayseri 38039, Turkey
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Author to whom correspondence should be addressed.
†
Presented at the 2nd International Conference on Natural Products for Cancer Prevention and Therapy, Kayseri, Turkey, 8–11 November 2017.
Proceedings 2017, 1(10), 1077; https://doi.org/10.3390/proceedings1101077
Published: 13 November 2017
(This article belongs to the Proceedings of Proceedings of the 2nd International Conference on Natural Products for Cancer Prevention and Therapy)
Abstract
:Achillea millefolium L. an herbaceous perennial plant from Asteraceae family which has antitumor, anti-inflammatory and antioxidant activity. Breast cancer is the most common cancer in woman. Therefore, in this study we aimed to investigate the effects of the different extracts of A. millefolium on breast cancer with in vitro cytotoxicity assay. Within the scope of this study, the compositions of extracts prepared with water, 30% ethanol, 60% ethanol, 90% ethanol and absolute ethanol obtained from the above-ground parts of A. millefolium, was investigated by Folin-Ciocalteu method for total phenolics, AlCl3 colorimetric method for total flavonoid content. Cytotoxic effects on MCF7 (human breast cancer cell line) cell line were studied with MTT assay. It has been elucidated that 60% ethanol extract is rich in total phenolics content and 90% ethanol extract is rich in total flavonoid content. Water extract was found to be most cytotoxic extract with 30.67 ± 2.27 µg/mL IC50 value on MCF7 cell line.
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MDPI and ACS Style
Köngül, E.; Taş, Ö.; Paşayeva, L.; Karatoprak, G.Ş. Analysis of the Cytotoxic Effects of Achillea millefolium L. Extracts on MCF7 Cell Line. Proceedings 2017, 1, 1077. https://doi.org/10.3390/proceedings1101077
AMA Style
Köngül E, Taş Ö, Paşayeva L, Karatoprak GŞ. Analysis of the Cytotoxic Effects of Achillea millefolium L. Extracts on MCF7 Cell Line. Proceedings. 2017; 1(10):1077. https://doi.org/10.3390/proceedings1101077
Chicago/Turabian StyleKöngül, Esra, Ömer Taş, Leyla Paşayeva, and Gökçe Şeker Karatoprak. 2017. "Analysis of the Cytotoxic Effects of Achillea millefolium L. Extracts on MCF7 Cell Line" Proceedings 1, no. 10: 1077. https://doi.org/10.3390/proceedings1101077
