Next Article in Journal
Celastrol Modulates Lipid Synthesis via PI3K/Akt/mTOR Signaling Axis to finalize Cell Death Response in Prostate Cancer Cells
Previous Article in Journal
Effect of a Synthesized Compound against Cancerous Cell Line and Synthesis of Copper Ion Incorporated 1-(3,4-Diaminophenyl) Ethanone-Based Hybrid Nanoflowers
Article Menu
Issue 10 (NPCPT 2017) cover image

Article Versions

Export Article

Open AccessAbstract
Proceedings 2017, 1(10), 1005;

Cyclodextrine Based Nanogels and Phase Solubility Studies of Flurbiprofen as a Chemopreventive Agent

Department of Pharmaceutical Technology, Faculty of Pharmacy, Gazi University, Etiler 06330, Ankara, Turkey
Presented at the 2nd International Conference on Natural Products for Cancer Prevention and Therapy, Kayseri, Turkey, 8–11 November 2017.
Author to whom correspondence should be addressed.
Published: 15 November 2017
PDF [151 KB, uploaded 15 November 2017]


Abstract: Flurbiprofen (FB) is one of the nonsteroidal anti-inflammatory drugs (NSAIDs) which has low water solubility (1). In recent studies it is shown that NSAIDs tend to demonstrate chemopreventive activity and chemoprotective agents frequently show low water solubility (2). In this study FB was selected as a model drug. Cyclodextrins (CDs) which are natural products and have special structure (hydrophobic inner phase and hydrophilic outer phase), have been widely used to enhance solubility and stability of drug substances (3). The objective of this study was to prepare CD based nanogels for increasing solubility and stability of FB. Nanogels were prepared with two different ratio (0.02 and 20%) and type of CD (βCD and HPβCD) using emulsification-solvent evaporation technique. Particle size (PS), polydispersity index (PDI), zeta potential (ZP) were investigated and phase solubility studies were performed to optimize CD based nanogels. According to results of phase solubility studies; it was achieved to enhance water solubility of FB with HPβCD 56.7 fold. PS, PDI and ZP were found as 154.5 ± 3.1 nm, 0.25 ± 0.01, −60 ± 2 mV for 0.02% HPβCD and 270.7 ± 58.2nm, 0.52 ± 0.06, −28.9 ± 2.3 mV for 20% HPβCD respectively. It can be concluded that HPβCD based nanogels can be promising carriers for FB as a chemopreventive agent.
Keywords: chemopreventive; flurbiprofen; cyclodextrin; solubility; nanogel chemopreventive; flurbiprofen; cyclodextrin; solubility; nanogel
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

Share & Cite This Article

MDPI and ACS Style

Oktay, A.N.; Tamer, S.İ.; Çelebi, N. Cyclodextrine Based Nanogels and Phase Solubility Studies of Flurbiprofen as a Chemopreventive Agent. Proceedings 2017, 1, 1005.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Metrics

Article Access Statistics



[Return to top]
Proceedings EISSN 2504-3900 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top