Methods Protoc., Volume 2, Issue 4 (December 2019) – 13 articles
Cover Story (view full-size image): Hypertrophic cardiomyopathy is a prevalent and complex cardiovascular disease with no effective therapeutics available. Disease modeling approaches have often generated contradictory results due to various model limitations and/or methodological constraints. Here, we provide three technically-refined and unbiased high-throughput protocols to phenotype cellular models of this disease. These will facilitate the discovery of novel pathological molecular mechanisms towards more efficient drug screening strategies to treat this condition. View this paper.
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