Next Article in Journal
The Inhibition of Radial and Axial Micromovement of Bone Scaffold with Gelfoam® and Titanium Mesh Fixation and Its Effects on Osteointegration
Previous Article in Journal
Campylobacter Phage Isolation and Characterization: What We Have Learned So Far
Open AccessProtocol

Protocol for Construction of Rat Nerve Stimulation Cuff Electrodes

1
School of Brain and Behavioral Sciences, The University of Texas at Dallas, Richardson, TX 75080-3021, USA
2
School of Biomedical Engineering, The University of Texas at Dallas, Richardson, TX 75080-3021, USA
3
Texas Biomedical Device Center (TxBDC), The University of Texas at Dallas, Richardson, TX 75080-3021, USA
*
Author to whom correspondence should be addressed.
Methods Protoc. 2019, 2(1), 19; https://doi.org/10.3390/mps2010019
Received: 10 January 2019 / Revised: 30 January 2019 / Accepted: 12 February 2019 / Published: 15 February 2019
Peripheral nerve stimulation has emerged as a platform therapy to treat a wide range of disorders. Continued development and translation of these strategies requires that researchers have access to reliable, customizable electrodes for nerve stimulation. Here, we detail procedures to build three different configurations of cuff electrodes with varying numbers and orientations of contacts for nerve stimulation in rats. These designs are built with simple, widely available materials, using platinum–iridium electrodes assembled into polyurethane tubing. Moreover, the designs can easily be customized to increase versatility and individualize for specific stimulation applications. This protocol provides a resource to facilitate the construction and customization of stimulation cuffs to support preclinical nerve stimulation research.
Video sections
View Full-Text
Keywords: vagus nerve stimulation; vagus nerve; cuff electrode; micro-construction; vagal nerve vagus nerve stimulation; vagus nerve; cuff electrode; micro-construction; vagal nerve
Show Figures

Figure 1

MDPI and ACS Style

Rios, M.U.; Bucksot, J.E.; Rahebi, K.C.; Engineer, C.T.; Kilgard, M.P.; Hays, S.A. Protocol for Construction of Rat Nerve Stimulation Cuff Electrodes. Methods Protoc. 2019, 2, 19.

Show more citation formats Show less citations formats
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Back to TopTop