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Tomography
Volume 5
Issue 1
10.18383/j.tom.2018.00019
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Tomography is published by MDPI from Volume 7 Issue 1 (2021). Previous articles were published by another publisher in Open Access under a CC-BY (or CC-BY-NC-ND) licence, and they are hosted by MDPI on mdpi.com as a courtesy and upon agreement with Grapho, LLC.
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Article

Magnetization Transfer MRI of Breast Cancer in the Community Setting: Reproducibility and Preliminary Results in Neoadjuvant Therapy

by
John Virostko
*,
Anna G. Sorace
,
Chengyue Wu
,
David Ekrut
,
Angela M. Jarrett
,
Raghave M. Upadhyaya
,
Sarah Avery
,
Debra Patt
,
Boone Goodgame
and
Thomas E. Yankeelov
*
Author to whom correspondence should be addressed.
Tomography 2019, 5(1), 44-52; https://doi.org/10.18383/j.tom.2018.00019
Submission received: 2 January 2019 / Revised: 4 February 2019 / Accepted: 10 February 2019 / Published: 1 March 2019
Versions Notes

Abstract

Repeatability and reproducibility of magnetization transfer magnetic resonance imaging of the breast, and the ability of this technique to assess the response of locally advanced breast cancer to neoadjuvant therapy (NAT), are determined. Reproducibility scans at 3 different 3 T scanners, including 2 scanners in community imaging centers, found a 16.3% difference (n = 3) in magnetization transfer ratio (MTR) in healthy breast fibroglandular tissue. Repeatability scans (n = 10) found a difference of ∼8.1% in the MTR measurement of fibroglandular tissue between the 2 measurements. Thus, MTR is repeatable and reproducible in the breast and can be integrated into community imaging clinics. Serial magnetization transfer magnetic resonance imaging performed at longitudinal time points during NAT indicated no significant change in average tumoral MTR during treatment. However, histogram analysis indicated an increase in the dispersion of MTR values of the tumor during NAT, as quantified by higher standard deviation (P = .005), higher full width at half maximum (P = .02), and lower kurtosis (P = .02). Patients' stratification into those with pathological complete response (pCR; n = 6) at the conclusion of NAT and those with residual disease (n = 9) showed wider distribution of tumor MTR values in patients who achieved pCR after 2–4 cycles of NAT, as quantified by higher standard deviation (P = .02), higher full width at half maximum (P = .03), and lower kurtosis (P = .03). Thus, MTR can be used as an imaging metric to assess response to breast NAT.
Keywords: MT-MRI; MTR; NAT; reproducibility; repeatability MT-MRI; MTR; NAT; reproducibility; repeatability

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MDPI and ACS Style

Virostko, J.; Sorace, A.G.; Wu, C.; Ekrut, D.; Jarrett, A.M.; Upadhyaya, R.M.; Avery, S.; Patt, D.; Goodgame, B.; Yankeelov, T.E. Magnetization Transfer MRI of Breast Cancer in the Community Setting: Reproducibility and Preliminary Results in Neoadjuvant Therapy. Tomography 2019, 5, 44-52. https://doi.org/10.18383/j.tom.2018.00019

AMA Style

Virostko J, Sorace AG, Wu C, Ekrut D, Jarrett AM, Upadhyaya RM, Avery S, Patt D, Goodgame B, Yankeelov TE. Magnetization Transfer MRI of Breast Cancer in the Community Setting: Reproducibility and Preliminary Results in Neoadjuvant Therapy. Tomography. 2019; 5(1):44-52. https://doi.org/10.18383/j.tom.2018.00019

Chicago/Turabian Style

Virostko, John, Anna G. Sorace, Chengyue Wu, David Ekrut, Angela M. Jarrett, Raghave M. Upadhyaya, Sarah Avery, Debra Patt, Boone Goodgame, and Thomas E. Yankeelov. 2019. "Magnetization Transfer MRI of Breast Cancer in the Community Setting: Reproducibility and Preliminary Results in Neoadjuvant Therapy" Tomography 5, no. 1: 44-52. https://doi.org/10.18383/j.tom.2018.00019

APA Style

Virostko, J., Sorace, A. G., Wu, C., Ekrut, D., Jarrett, A. M., Upadhyaya, R. M., Avery, S., Patt, D., Goodgame, B., & Yankeelov, T. E. (2019). Magnetization Transfer MRI of Breast Cancer in the Community Setting: Reproducibility and Preliminary Results in Neoadjuvant Therapy. Tomography, 5(1), 44-52. https://doi.org/10.18383/j.tom.2018.00019

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