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Tomography
Volume 5
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10.18383/j.tom.2018.00044
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Article

Repeatability of Quantitative Diffusion-Weighted Imaging Metrics in Phantoms, Head-and-Neck and Thyroid Cancers: Preliminary Findings

by
Ramesh Paudyal
1,
Amaresha Shridhar Konar
1,
Nancy A. Obuchowski
2,
Vaios Hatzoglou
3,
Thomas L. Chenevert
4,
Dariya I. Malyarenko
4,
Scott D. Swanson
4,
Eve LoCastro
1,
Sachin Jambawalikar
5,
Michael Z. Liu
5,
Lawrence H. Schwartz
5,
R. Michael Tuttle
6,
Nancy Lee
7 and
Amita Shukla-Dave
1,3,*
1
Department of Medical Physics, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA
2
Department of Quantitative Health Sciences, Cleveland Clinic Foundation, Cleveland, OH 44195, USA
3
Department of Radiology, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA
4
Department of Radiology, University of Michigan, Ann Arbor, MI 48109, USA
5
Department of Radiology, Columbia University Irving Medical Center, and New York Presbyterian Hospital, New York, NY 10065, USA
6
Departments of Medicine, New York, NY 10065, USA
7
Radiation Oncology, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA
*
Author to whom correspondence should be addressed.
Tomography 2019, 5(1), 15-25; https://doi.org/10.18383/j.tom.2018.00044
Submission received: 11 December 2018 / Revised: 4 January 2019 / Accepted: 5 February 2019 / Published: 1 March 2019
Versions Notes

Abstract

The aim of this study was to establish the repeatability measures of quantitative Gaussian and non-Gaussian diffusion metrics using diffusion-weighted imaging (DWI) data from phantoms and patients with head-and-neck and papillary thyroid cancers. The Quantitative Imaging Biomarker Alliance (QIBA) DWI phantom and a novel isotropic diffusion kurtosis imaging phantom were scanned at 3 different sites, on 1.5T and 3T magnetic resonance imaging systems, using standardized multiple b-value DWI acquisition protocol. In the clinical component of this study, a total of 60 multiple b-value DWI data sets were analyzed for test–retest, obtained from 14 patients (9 head-and-neck squamous cell carcinoma and 5 papillary thyroid cancers). Repeatability of quantitative DWI measurements was assessed by within-subject coefficient of variation (wCV%) and Bland–Altman analysis. In isotropic diffusion kurtosis imaging phantom vial with 2% ceteryl alcohol and behentrimonium chloride solution, the mean apparent diffusion (Dapp × 10−3 mm2/s) and kurtosis (Kapp, unitless) coefficient values were 1.02 and 1.68 respectively, capturing in vivo tumor cellularity and tissue microstructure. For the same vial, Dapp and Kapp mean wCVs (%) were ≤1.41% and ≤0.43% for 1.5T and 3T across 3 sites. For pretreatment head-and-neck squamous cell carcinoma, apparent diffusion coefficient, D, D*, K, and f mean wCVs (%) were 2.38%, 3.55%, 3.88%, 8.0%, and 9.92%, respectively; wCVs exhibited a higher trend for papillary thyroid cancers. Knowledge of technical precision and bias of quantitative imaging metrics enables investigators to properly design and power clinical trials and better discern between measurement variability versus biological change.
Keywords: quantitative imaging; repeatability; diffusion-weighted imaging; head and neck cancer; thyroid; cancer; within-subject coefficient of variation quantitative imaging; repeatability; diffusion-weighted imaging; head and neck cancer; thyroid; cancer; within-subject coefficient of variation

Share and Cite

MDPI and ACS Style

Paudyal, R.; Konar, A.S.; Obuchowski, N.A.; Hatzoglou, V.; Chenevert, T.L.; Malyarenko, D.I.; Swanson, S.D.; LoCastro, E.; Jambawalikar, S.; Liu, M.Z.; et al. Repeatability of Quantitative Diffusion-Weighted Imaging Metrics in Phantoms, Head-and-Neck and Thyroid Cancers: Preliminary Findings. Tomography 2019, 5, 15-25. https://doi.org/10.18383/j.tom.2018.00044

AMA Style

Paudyal R, Konar AS, Obuchowski NA, Hatzoglou V, Chenevert TL, Malyarenko DI, Swanson SD, LoCastro E, Jambawalikar S, Liu MZ, et al. Repeatability of Quantitative Diffusion-Weighted Imaging Metrics in Phantoms, Head-and-Neck and Thyroid Cancers: Preliminary Findings. Tomography. 2019; 5(1):15-25. https://doi.org/10.18383/j.tom.2018.00044

Chicago/Turabian Style

Paudyal, Ramesh, Amaresha Shridhar Konar, Nancy A. Obuchowski, Vaios Hatzoglou, Thomas L. Chenevert, Dariya I. Malyarenko, Scott D. Swanson, Eve LoCastro, Sachin Jambawalikar, Michael Z. Liu, and et al. 2019. "Repeatability of Quantitative Diffusion-Weighted Imaging Metrics in Phantoms, Head-and-Neck and Thyroid Cancers: Preliminary Findings" Tomography 5, no. 1: 15-25. https://doi.org/10.18383/j.tom.2018.00044

APA Style

Paudyal, R., Konar, A. S., Obuchowski, N. A., Hatzoglou, V., Chenevert, T. L., Malyarenko, D. I., Swanson, S. D., LoCastro, E., Jambawalikar, S., Liu, M. Z., Schwartz, L. H., Tuttle, R. M., Lee, N., & Shukla-Dave, A. (2019). Repeatability of Quantitative Diffusion-Weighted Imaging Metrics in Phantoms, Head-and-Neck and Thyroid Cancers: Preliminary Findings. Tomography, 5(1), 15-25. https://doi.org/10.18383/j.tom.2018.00044

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