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Allergies, Volume 5, Issue 3

September 2025 - 10 articles

Cover Story: This cover image illustrates the immunological tug-of-war between allergy and tuberculosis, mediated by mast cells (MCs). Positioned at the center, the MC symbolizes a critical immune hub caught between IgE-driven allergic responses and Mycobacterium tuberculosis-induced inflammation. The allergen particles entering the nasal passage contrast with tuberculosis bacteria, each pulling immune signaling in opposing directions. The image visualizes how allergic Th2-skewed immunity may undermine Th1 responses essential for TB control, highlighting the dual role of MCs in modulating immunity and pathology. This visual metaphor supports the review’s focus on how environmental, genetic, and immunological factors influence MC activity and TB outcomes, and explores potential host-directed therapies targeting mast cells. View this paper
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Articles (10)

  • Review
  • Open Access
1,651 Views
15 Pages

Understanding Insect Bite Hypersensitivity in Horses: A Narrative Review for Clinical Practice

  • Alexandra Nicoleta Mureșan,
  • Ilinca Maria Țăpuc and
  • Daniela Mihaela Neagu

22 September 2025

Insect bite hypersensitivity (IBH) is a seasonally recurrent allergic dermatitis representing one of the most prevalent dermatological conditions in horses worldwide. This condition, driven by hypersensitivity to salivary allergens of Culicoides spp....

  • Review
  • Open Access
1,103 Views
16 Pages

Mast Cells in Tuberculosis: Immune Regulation, Allergic Environments, and Pathological Mechanisms

  • Seung Hoon Lee,
  • Gunhyuk Park,
  • Hye-Sun Lim,
  • Yoonseo Hong and
  • Huiyun Seo

4 September 2025

Mast cells (MC) are key effector cells in allergic diseases and are increasingly recognized for their roles in the immunopathogenesis of tuberculosis (TB). In allergic conditions, MCs are hyperactivated, driving T-helper Type 2 (Th2)-skewed immune re...

  • Review
  • Open Access
2,394 Views
38 Pages

Medium and variable vessel vasculitides are a heterogeneous group of rare, immune-mediated vascular disorders that are associated with significant morbidity and mortality. The standard treatment approach involves glucocorticoids and immunosuppressive...

  • Review
  • Open Access
2,417 Views
10 Pages

Food Allergy-Associated Cutaneous Manifestations in Children: A Narrative Review

  • Annabel Hou,
  • Joyce J. Zhu,
  • Pratiksha Patra and
  • Sharon Albers

The rising prevalence of pediatric food allergies represents a growing public health concern, with hospitalizations for food-induced anaphylaxis on the rise. Early cutaneous manifestations, particularly in the setting of atopic dermatitis (AD), may i...

  • Article
  • Open Access
1,246 Views
12 Pages

Retrospective Study on Acute Effects of Mount Etna Volcanic Eruption in Patients with Atopic Dermatitis

  • Federica Trovato,
  • Antonio Di Guardo,
  • Alessandra Rallo,
  • Annunziata Dattola,
  • Elena Zappia,
  • Steven Paul Nisticò and
  • Giovanni Pellacani

Mount Etna, located on the eastern coast of Sicily, is Europe’s most active volcano. Over the past five years, it has experienced numerous significant eruptive episodes, with the most recent occurring in August 2024. During this event, substant...

  • Review
  • Open Access
2,391 Views
22 Pages

Multiple sclerosis (MS) and allergic diseases, traditionally considered immunologically opposing entities, may share pathogenic mechanisms rooted in immune dysregulation. While MS is predominantly mediated by Th1 and Th17 responses and allergies by T...

  • Article
  • Open Access
1,455 Views
12 Pages

Teacher Self-Efficacy in Asthma Management in Elementary and Middle Schools

  • Ethan Schilling,
  • Stacey Neuharth-Pritchett,
  • Sofia H. Davie and
  • Yvette Q. Getch

Background/Objectives: This study assessed teacher self-efficacy in school-based asthma management in two southern states in the United States. Current literature focuses primarily on supporting school-based asthma management, but few studies have fo...

  • Article
  • Open Access
1,705 Views
13 Pages

Toxocara spp. Infection Influences on Eosinophil Levels: An Immunological Indicator of Severe Asthma and Allergy

  • Raphael Chagas Silva,
  • Márcia Barbosa da Silva,
  • Alana Alcantara Galvão,
  • Jamile Souza Fernandes,
  • Gabriela Pimentel Pinheiro,
  • Álvaro A. Cruz,
  • Carina da Silva Pinheiro and
  • Neuza Maria Alcântara-Neves

Background/Objectives: Toxocara spp. infection has been associated with severe asthma and allergic manifestations due to the activation of eosinophils by the release of Th2 cell cytokines. The aim of this study was to investigate the association betw...

  • Article
  • Open Access
1,103 Views
19 Pages

Exploring Molecular Responses to Aeroallergens in Respiratory Allergy Across Six Locations in Peru

  • Oscar Manuel Calderón-Llosa,
  • César Alberto Galván,
  • María José Martínez,
  • Ruperto González-Pérez,
  • Eva Abel-Fernández and
  • Fernando Pineda

Allergic diseases, particularly respiratory allergies like asthma and allergic rhinitis, are a growing public health concern influenced by environmental factors such as climate change and air pollution. The exposome framework enables a comprehensive...

  • Review
  • Open Access
2,496 Views
22 Pages

Affecting around 30–40% of the population worldwide, allergic disorders including asthma, rhinitis, eczema, and food allergies, are relatively common. Environmental factors, such as air pollution and climate change, which aggravate allergic rea...

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Allergies - ISSN 2313-5786