Journal of Imaging, Volume 12, Issue 3
2026 March - 50 articles
Cover Story: Resolving individual neurons across whole intact organs, from transgenic mouse brains to centimeter-thick human tissue slabs, is a defining challenge in modern neuroscience. This cover image demonstrates ClearScope, a light-sheet theta microscope from MBF Bioscience designed to meet that challenge. Hundreds of neuronal cell bodies, dendrites, and axons are visible across cleared Thy1-eGFP mouse cerebral cortex, captured here with a 10× objective and 488 nm laser excitation. The vivid color palette is a depth encoding: hue maps position along the optical axis, compressing the full 3D tissue volume into one striking 2D projection. By using dual oblique illumination with perpendicular detection, ClearScope eliminates the lateral size constraints inherent to conventional light-sheet designs. View this paper
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J. Imaging - ISSN 2313-433X