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Gels, Volume 4, Issue 3

2018 September - 24 articles

Cover Story: Hydrogel nanoparticles and nanostructured drug delivery systems incorporated in hydrogels provide safer and more effective strategies than those of conventional chemotherapeutic regimens. The nanoparticles may be systemically administered, using targeting moieties to identify and efficiently kill tumor cells. Hydrogels, due to the macroscopic size of the matrix, may be administrated locally, providing a controlled drug release without compromising healthy cells and tissues. View Paper here.
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Articles (24)

  • Feature Paper
  • Article
  • Open Access
10 Citations
5,382 Views
14 Pages

15 September 2018

Emulsions can be prepared from protein microgel particles as an alternative to traditional emulsifiers. Prior experiments have indicated that smaller and more deformable microgels would decrease both the physical destabilization of emulsions and the...

  • Article
  • Open Access
20 Citations
6,031 Views
14 Pages

12 September 2018

Gelled lyotropic liquid crystals can be formed by adding a gelator to a mixture of surfactant and solvent. If the gel network and the liquid-crystalline phase coexist without influencing each other, the self-assembly is called orthogonal. In this stu...

  • Feature Paper
  • Review
  • Open Access
116 Citations
11,262 Views
12 Pages

10 September 2018

A variety of cryogenically-structured polymeric materials are of significant scientific and applied interest in various areas. However, in spite of considerable attention to these materials and intensive elaboration of their new examples, as well as...

  • Review
  • Open Access
103 Citations
12,080 Views
15 Pages

Nanocomposite Hydrogels: Advances in Nanofillers Used for Nanomedicine

  • Arti Vashist,
  • Ajeet Kaushik,
  • Anujit Ghosal,
  • Jyoti Bala,
  • Roozbeh Nikkhah-Moshaie,
  • Waseem A. Wani,
  • Pandiaraj Manickam and
  • Madhavan Nair

6 September 2018

The ongoing progress in the development of hydrogel technology has led to the emergence of materials with unique features and applications in medicine. The innovations behind the invention of nanocomposite hydrogels include new approaches towards syn...

  • Feature Paper
  • Article
  • Open Access
10 Citations
4,392 Views
20 Pages

Electrodiffusion-Mediated Swelling of a Two-Phase Gel Model of Gastric Mucus

  • Owen L. Lewis,
  • James P. Keener and
  • Aaron L. Fogelson

6 September 2018

Gastric mucus gel is known to exhibit dramatic and unique swelling behaviors in response to the ionic composition of the hydrating solution. This swelling behavior is important in the maintenance of the mucus layer lining the stomach wall, as the lay...

  • Article
  • Open Access
16 Citations
7,018 Views
12 Pages

A Comparative Study of a 3D Bioprinted Gelatin-Based Lattice and Rectangular-Sheet Structures

  • Shweta Anil Kumar,
  • Nishat Tasnim,
  • Erick Dominguez,
  • Shane Allen,
  • Laura J. Suggs,
  • Yoshihiro Ito and
  • Binata Joddar

4 September 2018

3D bioprinting holds great promise in the field of regenerative medicine as it can create complex structures in a layer-by-layer manner using cell-laden bioinks, making it possible to imitate native tissues. Current bioinks lack both high printabilit...

  • Article
  • Open Access
48 Citations
8,449 Views
12 Pages

Hydrogel-Nanoparticles Composite System for Controlled Drug Delivery

  • Emanuele Mauri,
  • Anna Negri,
  • Erica Rebellato,
  • Maurizio Masi,
  • Giuseppe Perale and
  • Filippo Rossi

4 September 2018

Biodegradable poly(ethylene glycol)-block-poly(-lactic acid) (PEG-b-PLA) nanoparticles (NPs) were prepared by nanoprecipitation with controlled dimension and with different electric charges, as monitored by dynamic light scattering (DLS). Then NPs we...

  • Feature Paper
  • Review
  • Open Access
43 Citations
11,358 Views
22 Pages

2 September 2018

Hydrogels are three-dimensional networks composed of hydrated polymer chains and have been a material of choice for many biomedical applications such as drug delivery, biosensing, and tissue engineering due to their unique biocompatibility, tunable p...

  • Feature Paper
  • Article
  • Open Access
12 Citations
5,442 Views
9 Pages

30 August 2018

Our recent studies have shown that the hydrogels prepared by blending clay, a dispersant of clay, and a polyelectrolyte (sodium polyacrylate (PAAS)) possess excellent mechanical properties. In order to clarify the mechanism of the toughness, we have...

  • Article
  • Open Access
34 Citations
5,046 Views
13 Pages

17 August 2018

The behavior of poly(sodium acrylate-co-acrylamide) copolymer hydrogels with varied chemical compositions in artificial pore solutions with three different pH values is examined. The absorption, chemical characteristics, mechanical stiffness, and des...

  • Feature Paper
  • Article
  • Open Access
33 Citations
9,308 Views
17 Pages

Extrusion-Based 3D Printing of Poly(ethylene glycol) Diacrylate Hydrogels Containing Positively and Negatively Charged Groups

  • Sebastian Joas,
  • Günter E. M. Tovar,
  • Oguz Celik,
  • Christian Bonten and
  • Alexander Southan

14 August 2018

Hydrogels are an interesting class of materials used in extrusion-based 3D printing, e.g., for drug delivery or tissue engineering. However, new hydrogel formulations for 3D printing as well as a detailed understanding of crucial formulation properti...

  • Article
  • Open Access
62 Citations
8,803 Views
14 Pages

A Methylcellulose Hydrogel as Support for 3D Plotting of Complex Shaped Calcium Phosphate Scaffolds

  • Tilman Ahlfeld,
  • Tino Köhler,
  • Charis Czichy,
  • Anja Lode and
  • Michael Gelinsky

11 August 2018

3D plotting is an additive manufacturing technology enabling biofabrication, thus the integration of cells or biologically sensitive proteins or growth factors into the manufacturing process. However, most (bio-)inks developed for 3D plotting were no...

  • Review
  • Open Access
117 Citations
14,240 Views
29 Pages

Concepts for Developing Physical Gels of Chitosan and of Chitosan Derivatives

  • Pasquale Sacco,
  • Franco Furlani,
  • Gaia De Marzo,
  • Eleonora Marsich,
  • Sergio Paoletti and
  • Ivan Donati

9 August 2018

Chitosan macro- and micro/nano-gels have gained increasing attention in recent years, especially in the biomedical field, given the well-documented low toxicity, degradability, and non-immunogenicity of this unique biopolymer. In this review we aim a...

  • Article
  • Open Access
23 Citations
6,543 Views
11 Pages

Millimeter-Size Spherical Polyurea Aerogel Beads with Narrow Size Distribution

  • Despoina Chriti,
  • Grigorios Raptopoulos,
  • Maria Papastergiou and
  • Patrina Paraskevopoulou

6 August 2018

We report the room temperature synthesis of spherical millimeter-size polyurea (PUA) aerogel beads. Wet-gels of said beads were obtained by dripping a propylene carbonate solution of an aliphatic triisocyanate based on isocyanurate nodes into a mixtu...

  • Feature Paper
  • Article
  • Open Access
22 Citations
6,340 Views
10 Pages

2 August 2018

Cancer research has traditionally relied on two-dimensional (2D) cell culture, focusing mainly on cancer cells and their abnormal genetics. However, over the past decade, tumors have been accepted as complex tissues rather than a homogenous mass of p...

  • Article
  • Open Access
13 Citations
5,147 Views
16 Pages

Photocrosslinked Dextran-Based Hydrogels as Carrier System for the Cells and Cytokines Induce Bone Regeneration in Critical Size Defects in Mice

  • Ulrike Ritz,
  • Marc Eberhardt,
  • Anja Klein,
  • Petra Frank,
  • Hermann Götz,
  • Alexander Hofmann,
  • Pol Maria Rommens and
  • Ulrich Jonas

20 July 2018

Modified biomaterials have for years been the focus of research into establishing new bone substitutes. In our preceding in vitro study employing different cell cultures, we developed chemically and mechanically characterized hydrogels based on photo...

  • Feature Paper
  • Review
  • Open Access
108 Citations
16,774 Views
28 Pages

Hydrogel-Based Drug Delivery Nanosystems for the Treatment of Brain Tumors

  • João Basso,
  • Ana Miranda,
  • Sandra Nunes,
  • Tânia Cova,
  • João Sousa,
  • Carla Vitorino and
  • Alberto Pais

19 July 2018

Chemotherapy is commonly associated with limited effectiveness and unwanted side effects in normal cells and tissues, due to the lack of specificity of therapeutic agents to cancer cells when systemically administered. In brain tumors, the existence...

  • Review
  • Open Access
104 Citations
10,885 Views
30 Pages

11 July 2018

Hydrogels are materials specially suited for encapsulation of biological elements. Their large water content provides an environment compatible with most biological molecules. Their crosslinked nature also provides an ideal material for the protectio...

  • Article
  • Open Access
8 Citations
5,806 Views
20 Pages

9 July 2018

We present a scaling model based on a moving boundary picture to describe heterogeneous gelation dynamics. The dynamics of gelation induced by different gelation mechanisms is expressed by the scaled equation for the time taken for development of the...

  • Article
  • Open Access
7 Citations
5,041 Views
9 Pages

26 June 2018

The gelation and structural formation of two types of amylose in alkaline solution by in situ neutralization was monitored with time-resolved small-angle X-ray scattering (tr-SAXS). Sharp increases of SAXS profile in lower angle region were observed...

  • Article
  • Open Access
9 Citations
5,359 Views
17 Pages

Dynamic Behaviors of Solvent Molecules Restricted in Poly (Acryl Amide) Gels Analyzed by Dielectric and Diffusion NMR Spectroscopy

  • Hironobu Saito,
  • Shunpei Kato,
  • Keisuke Matsumoto,
  • Yuya Umino,
  • Rio Kita,
  • Naoki Shinyashiki,
  • Shin Yagihara,
  • Minoru Fukuzaki and
  • Masayuki Tokita

22 June 2018

Dynamics of solvent molecules restricted in poly (acryl amide) gels immersed in solvent mixtures of acetone–, 1,4-dioxane–, and dimethyl sulfoxide–water were analyzed by the time domain reflectometry method of dielectric spectroscop...

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Gels - ISSN 2310-2861