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Hydrogel-Nanoparticles Composite System for Controlled Drug Delivery

1
Department of Chemistry, Materials and Chemical Engineering “G. Natta”, Politecnico di Milano, via Mancinelli 7, 20131 Milan, Italy
2
Biomaterials Laboratory, Institute for Mechanical Engineering and Materials Technology, SUPSI—University of Applied Sciences and Arts of Southern Switzerland, via Cantonale 2C, Galleria 2, 6928 Manno, Switzerland
*
Author to whom correspondence should be addressed.
Received: 26 July 2018 / Revised: 20 August 2018 / Accepted: 29 August 2018 / Published: 4 September 2018
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Abstract

Biodegradable poly(ethylene glycol)-block-poly(-lactic acid) (PEG-b-PLA) nanoparticles (NPs) were prepared by nanoprecipitation with controlled dimension and with different electric charges, as monitored by dynamic light scattering (DLS). Then NPs were loaded within hydrogels (HG) developed for biomedical applications in the central nervous system, with different pore sizes (30 and 90 nm). The characteristics of the resulting composite hydrogel-NPs system were firstly studied in terms of ability to control the release of small steric hindrance drug mimetic. Then, diffusion-controlled release of different charged NPs from different entangled hydrogels was studied in vitro and correlated with NPs electric charges and hydrogel mean mesh size. These studies showed different trends, that depend on NPs superficial charge and HG mesh size. Release experiments and diffusion studies, then rationalized by mathematical modeling, allowed us to build different drug delivery devices that can satisfy different medical needs. View Full-Text
Keywords: drug delivery; hydrogel; polymeric nanoparticles; release system drug delivery; hydrogel; polymeric nanoparticles; release system
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Mauri, E.; Negri, A.; Rebellato, E.; Masi, M.; Perale, G.; Rossi, F. Hydrogel-Nanoparticles Composite System for Controlled Drug Delivery. Gels 2018, 4, 74.

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