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Thiol-Mediated Chemoselective Strategies for In Situ Formation of Hydrogels

Department of Chemistry, Northeastern Illinois University, Chicago, IL 60625, USA
Received: 31 July 2018 / Revised: 28 August 2018 / Accepted: 31 August 2018 / Published: 2 September 2018
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Abstract

Hydrogels are three-dimensional networks composed of hydrated polymer chains and have been a material of choice for many biomedical applications such as drug delivery, biosensing, and tissue engineering due to their unique biocompatibility, tunable physical characteristics, flexible methods of synthesis, and range of constituents. In many cases, methods for crosslinking polymer precursors to form hydrogels would benefit from being highly selective in order to avoid cross-reactivity with components of biological systems leading to adverse effects. Crosslinking reactions involving the thiol group (SH) offer unique opportunities to construct hydrogel materials of diverse properties under mild conditions. This article reviews and comments on thiol-mediated chemoselective and biocompatible strategies for crosslinking natural and synthetic macromolecules to form injectable hydrogels for applications in drug delivery and cell encapsulation. View Full-Text
Keywords: hydrogel; chemical crosslinking; chemoselective reaction; thiols hydrogel; chemical crosslinking; chemoselective reaction; thiols
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).
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Su, J. Thiol-Mediated Chemoselective Strategies for In Situ Formation of Hydrogels. Gels 2018, 4, 72.

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