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Gels, Volume 11, Issue 3

March 2025 - 70 articles

Cover Story: Self-healing hydrogels were synthesized using oxidized hydroxybutanoyl glycan (OHbG) and quaternized carboxymethyl chitosan (QCMCS). The successful modification of these polysaccharides was confirmed through 1H NMR analysis. A dual cross-linking mechanism, involving imine bonds and ionic interactions, enhanced the hydrogel’s self-healing ability and thermal stability, with improvements observed as the OHbG concentration increased. The hydrogel exhibited high compressive strength, significant swelling capacity, and pH-dependent drug release behavior. Additionally, it retained its antioxidant and antibacterial properties, as well as the inherent characteristics of the polysaccharides. These findings underscore the biocompatibility and stimuli-responsive nature of the OHbG/QCMCS hydrogel, making it a promising drug carrier for pharmaceutical and biomedical applications. View this paper
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Articles (70)

  • Article
  • Open Access
1 Citations
1,090 Views
21 Pages

20 March 2025

Diffuse large B-cell lymphoma (DLBCL), accounting for 31% of non-Hodgkin lymphomas, remains recalcitrant to conventional therapies due to chemoresistance, metastatic progression, and immunosuppressive microenvironments. We report a novel injectable F...

  • Article
  • Open Access
22 Citations
1,730 Views
17 Pages

20 March 2025

Efficient and precise cancer therapy remains a challenge due to limitations in current treatment modalities. In this study, we developed a multifunctional hydrogel system that integrates photothermal therapy (PTT) and chemotherapy to achieve combined...

  • Review
  • Open Access
4,190 Views
23 Pages

Hydrogel-Based Biomaterials: A Patent Landscape on Innovation Trends and Patterns

  • Ahmed Fatimi,
  • Fouad Damiri,
  • Nada El Arrach,
  • Houria Hemdani,
  • Adina Magdalena Musuc and
  • Mohammed Berrada

20 March 2025

The hydrogel patent landscape is characterized by rapid growth and diverse applications, particularly in the biomedical field. Advances in material science, chemistry, novel manufacturing techniques, and a deeper understanding of biological systems h...

  • Article
  • Open Access
1 Citations
1,104 Views
19 Pages

The Effects of Encapsulating Bioactive Irish Honey into Pluronic-Based Thermoresponsive Hydrogels and Potential Application in Soft Tissue Regeneration

  • Daniel P. Fitzpatrick,
  • Emma Browne,
  • Carmel Kealey,
  • Damien Brady,
  • Siobhan Kavanagh,
  • Sinead Devery and
  • Noel Gately

19 March 2025

Honey has been recognised for centuries for its potential therapeutic properties, and its application in wound healing has gained attention due to its antimicrobial, anti-inflammatory, and regenerative properties. With the rapid increase in multidrug...

  • Article
  • Open Access
3,580 Views
11 Pages

Improving Vaginal Health with a Zinc-Containing Vaginal Hydrogel

  • Dávid Rátonyi,
  • Barbara Kozma,
  • Attila G. Sipos,
  • Zoárd Tibor Krasznai,
  • Bence Kozma and
  • Peter Takacs

19 March 2025

Vulvovaginal symptoms affect up to 39% of women. These symptoms have a significant impact on quality of life and are often linked to imbalances in the vaginal microbiota. This study evaluates the therapeutic efficacy of a zinc-containing hydroxyethyl...

  • Article
  • Open Access
1 Citations
2,158 Views
23 Pages

18 March 2025

Mesenchymal stem cells (MSCs) can differentiate into chondrocytes provided with the appropriate environmental cues. In this study, we loaded human adipose-derived stem cells (hAdMSCs) into collagen/alginate hydrogels, which have been shown to induce...

  • Article
  • Open Access
2 Citations
1,703 Views
16 Pages

Combined Effect of pH and Neutralizing Solution Molarity on the Rheological Properties of Chitosan Hydrogels for Biomedical Applications

  • Sofia Jansen de Medeiros Alves,
  • Matheus Araújo Santos,
  • João Emídio da Silva Neto,
  • Henrique Nunes da Silva,
  • Milena C. S. Barbosa,
  • Marcus Vinicius Lia Fook,
  • Rômulo Feitosa Navarro and
  • Suédina Maria de Lima Silva

18 March 2025

Hydrogels are promising materials for biomedical applications due to their tunable properties. Despite significant research on optimizing the mechanical and rheological properties of chitosan hydrogels, a comprehensive analysis incorporating pH and m...

  • Article
  • Open Access
4 Citations
4,189 Views
20 Pages

16 March 2025

Industrial textile wastewater containing both heavy metals and dyes has been massively produced. In this study, semi-interpenetrating polymer network structures of sodium alginate (SA)/polyvinyl alcohol (PVA)/κ-carrageenan (CG) aerogel beads we...

  • Article
  • Open Access
1 Citations
1,366 Views
12 Pages

16 March 2025

To investigate the feasibility of cellulose extraction from lignocellulosic waste biomass using ionic liquids—a sustainable and efficient approach—for preparing cellulose aerogel adsorbents, we employed a fully green amino acid-derived io...

  • Article
  • Open Access
1,562 Views
18 Pages

Rheology and Printability of Hydroxyapatite/Sodium Alginate Bioinks Added with Bovine or Fish Collagen Peptides

  • Mario Milazzo,
  • Roberta Rovelli,
  • Claudio Ricci,
  • Teresa Macchi,
  • Giuseppe Gallone and
  • Serena Danti

15 March 2025

The high biocompatibility and the key role of collagen in bone extracellular matrix make it useful for tissue engineering. However, the high demand, costs, and challenges of extracting good-quality collagen have led to the use of collagen derivatives...

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Gels - ISSN 2310-2861