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Journal of Cardiovascular Development and Disease, Volume 11, Issue 4

April 2024 - 35 articles

Cover Story: This work shows, for the first time, that fetal mitral valve development in cattle (with a 9-month gestation period) differs from that in small mammals with shorter gestational periods. Bovine mitral valve development was also strikingly similar to that observed in humans, where chordae tendineae are present in the first trimester and increase in number as the leaflet grows over gestation. Chordae multiplication, however, halts at birth, despite the ongoing expansion of the leaflet post-partum. This shorter interval of development causes the chordae to lead the leaflet in development and reach functional maturity ahead of the leaflet. AL = anterior leaflet; CT = chordae tendineae. View this paper
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Articles (35)

  • Article
  • Open Access
1 Citations
2,156 Views
11 Pages

Validation of Perioperative Troponin Levels for Predicting Postoperative Mortality and Long-Term Survival in Patients Undergoing Surgery for Hepatobiliary and Pancreatic Cancer

  • Dimitrios E. Magouliotis,
  • Evangelos Tatsios,
  • Grigorios Giamouzis,
  • Athina A. Samara,
  • Andrew Xanthopoulos,
  • Alexandros Briasoulis,
  • John Skoularigis,
  • Thanos Athanasiou,
  • Metaxia Bareka and
  • Christos Kourek
  • + 1 author

Background: Hepatopancreato and biliary (HPB) tumors represent some of the leading cancer-related causes of death worldwide, with the majority of patients undergoing surgery in the context of a multimodal treatment strategy. Consequently, the impleme...

  • Article
  • Open Access
1 Citations
3,102 Views
15 Pages

Prevalence and Clinical Significance of Intraventricular Conduction Disturbances in Hospitalized Children

  • Chiara Cirillo,
  • Emanuele Monda,
  • Raffaella Esposito,
  • Diego Colonna,
  • Cristina Falcone,
  • Federica Irrissuto,
  • Annapaola Cirillo,
  • Adelaide Fusco,
  • Federica Verrillo and
  • Gaetano Diana
  • + 5 authors

Introduction: Data on the prevalence and clinical significance of interventricular conduction disturbances (IVCDs) in children are scarce. While incomplete right bundle branch blocks (IRBBBs) seem to be the most frequent and benign findings, complete...

  • Article
  • Open Access
2 Citations
3,649 Views
14 Pages

The association between normal-range triglyceride levels and diabetes mortality remains unclear. This cohort study aimed to elucidate this relationship by examining 19,010 US adult participants with fasting serum triglycerides below 150 mg/dL. Cox pr...

  • Review
  • Open Access
11 Citations
5,505 Views
15 Pages

Photon-counting detector computed tomography (PCD-CT) represents a revolutionary new generation of computed tomography (CT) for the imaging of patients with cardiovascular diseases. Since its commercial market introduction in 2021, numerous studies h...

  • Review
  • Open Access
5 Citations
3,664 Views
15 Pages

Patients with atherosclerotic disease remain at increased risk of future events despite receiving optimal medical treatment. This residual risk is widely heterogeneous, but lipoprotein particles and their content play a major role in determining futu...

  • Review
  • Open Access
4 Citations
4,322 Views
20 Pages

Novel Medical Treatments and Devices for the Management of Heart Failure with Reduced Ejection Fraction

  • Michele Alfieri,
  • Filippo Bruscoli,
  • Luca Di Vito,
  • Federico Di Giusto,
  • Giancarla Scalone,
  • Procolo Marchese,
  • Domenico Delfino,
  • Simona Silenzi,
  • Milena Martoni and
  • Federico Guerra
  • + 1 author

Heart failure (HF) is a growing issue in developed countries; it is often the result of underlying processes such as ischemia, hypertension, infiltrative diseases or even genetic abnormalities. The great majority of the affected patients present a re...

  • Article
  • Open Access
2,298 Views
12 Pages

Pulmonary hypertension (PH) can arise from several distinct disease processes, with a percentage presenting with combined pre- and postcapillary pulmonary hypertension (cpcPH). Patients with cpcPH are unsuitable candidates for PH-directed therapies d...

  • Article
  • Open Access
1 Citations
3,044 Views
11 Pages

Simplified Criteria for Identification of Familial Hypercholesterolemia in Children: Application in Real Life

  • Raffaele Buganza,
  • Giulia Massini,
  • Maria Donata Di Taranto,
  • Giovanna Cardiero,
  • Luisa de Sanctis and
  • Ornella Guardamagna

Background: The diagnosis of familial hypercholesterolemia (FH) in children is primarily based on main criteria including low-density lipoprotein cholesterol (LDL-C) levels, increased in the proband and relatives, and its inheritance. Two other relev...

  • Review
  • Open Access
10 Citations
6,033 Views
15 Pages

Non-Pharmacological Treatment of Heart Failure—From Physical Activity to Electrical Therapies: A Literature Review

  • Antonio Scarà,
  • Zefferino Palamà,
  • Antonio Gianluca Robles,
  • Lorenzo-Lupo Dei,
  • Alessio Borrelli,
  • Federico Zanin,
  • Leonardo Pignalosa,
  • Silvio Romano and
  • Luigi Sciarra

Heart failure (HF) represents a significant global health challenge that is still responsible for increasing morbidity and mortality despite advancements in pharmacological treatments. This review investigates the effectiveness of non-pharmacological...

  • Article
  • Open Access
2 Citations
2,108 Views
11 Pages

Inflammatory Cells in Adipose Tissue and Skeletal Muscle of Patients with Peripheral Arterial Disease or Chronic Venous Disease: A Prospective, Observational, and Histological Study

  • Joana Ferreira,
  • Adhemar Longatto-Filho,
  • Julieta Afonso,
  • Susana Roque,
  • Alexandre Lima Carneiro,
  • Isabel Vila,
  • Cristina Silva,
  • Cristina Cunha,
  • Amílcar Mesquita and
  • Jorge Cotter
  • + 3 authors

The main goal of this study was to assess whether the presence of peripheral arterial disease (PAD) correlates with increased inflammatory cell infiltration. An observational, single-centre, and prospective study was conducted from January 2018 to Ju...

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J. Cardiovasc. Dev. Dis. - ISSN 2308-3425