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Bioengineering, Volume 9, Issue 1

January 2022 - 41 articles

Cover Story: Bone healing post-trauma presents significant health challenges. Impaired bone healing may result in severe complications requiring multiple surgical interventions. The use of biomaterial scaffolds to aid bone repair and healing has been found to be helpful in these situations. Biomorphic rattan-wood scaffolds (B-HA) present characteristics resembling the structure of the bone. Our study evaluated the ability of donor-derived bone marrow mesenchymal stromal cells (BMSCs) and culture-expanded mesenchymal stromal cells (cMSCs) to attach, survive and express their genes on these B-HA scaffolds to potentially aid bone repair. View this paper
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Articles (41)

  • Article
  • Open Access
5 Citations
3,947 Views
12 Pages

Maxillary Transverse Deficit: A Retrospective Study of Two Biologically Oriented Devices through a Digital Workflow

  • Graziano Montaruli,
  • Simona Virgilio,
  • Michele Laurenziello,
  • Michele Tepedino and
  • Domenico Ciavarella

The aim of this retrospective study was to compare the efficiency of two biologically oriented devices in achieving maxillary expansion: Rapid Palatal Expander (RPE) and Nitanium Palatal Expander-2 (NPE-2). Thirty-six subjects, divided in two equal g...

  • Review
  • Open Access
34 Citations
5,139 Views
16 Pages

Metallurgical Tests in Endodontics: A Narrative Review

  • Alessio Zanza,
  • Marco Seracchiani,
  • Rodolfo Reda,
  • Gabriele Miccoli,
  • Luca Testarelli and
  • Dario Di Nardo

Since there are no reviews of the literature on this theme, the aim of this narrative review is to summarize the metallurgical tests used in endodontics, pointing out their functional use and their pros and cons and giving readers a user-friendly gui...

  • Article
  • Open Access
18 Citations
4,278 Views
16 Pages

Radiation-Induced Alterations in Proliferation, Migration, and Adhesion in Lens Epithelial Cells and Implications for Cataract Development

  • Graysen Vigneux,
  • Jake Pirkkanen,
  • Taylor Laframboise,
  • Hallie Prescott,
  • Sujeenthar Tharmalingam and
  • Christopher Thome

The lens of the eye is one of the most radiosensitive tissues. Although the exact mechanism of radiation-induced cataract development remains unknown, altered proliferation, migration, and adhesion have been proposed as factors. Lens epithelial cells...

  • Review
  • Open Access
59 Citations
12,564 Views
24 Pages

Organ on Chip Technology to Model Cancer Growth and Metastasis

  • Giorgia Imparato,
  • Francesco Urciuolo and
  • Paolo Antonio Netti

Organ on chip (OOC) has emerged as a major technological breakthrough and distinct model system revolutionizing biomedical research and drug discovery by recapitulating the crucial structural and functional complexity of human organs in vitro. OOC ar...

  • Systematic Review
  • Open Access
52 Citations
8,145 Views
16 Pages

Background: Alzheimer’s disease (AD) has paramount importance due to its rising prevalence, the impact on the patient and society, and the related healthcare costs. However, current diagnostic techniques are not designed for frequent mass scree...

  • Review
  • Open Access
26 Citations
7,090 Views
35 Pages

A Review on Damage and Rupture Modelling for Soft Tissues

  • Sai Naga Sri Harsha Chittajallu,
  • Ashutosh Richhariya,
  • Kwong Ming Tse and
  • Viswanath Chinthapenta

Computational modelling of damage and rupture of non-connective and connective soft tissues due to pathological and supra-physiological mechanisms is vital in the fundamental understanding of failures. Recent advancements in soft tissue damage models...

  • Article
  • Open Access
7 Citations
3,073 Views
15 Pages

Functionalizing Fibrin Hydrogels with Thermally Responsive Oligonucleotide Tethers for On-Demand Delivery

  • Chase S. Linsley,
  • Kevin Sung,
  • Cameron White,
  • Cara A. Abecunas,
  • Bill J. Tawil and
  • Benjamin M. Wu

There are a limited number of stimuli-responsive biomaterials that are capable of delivering customizable dosages of a therapeutic at a specific location and time. This is especially true in tissue engineering and regenerative medicine applications,...

  • Article
  • Open Access
7 Citations
4,662 Views
14 Pages

Unraveling the Mechanism of Platelet Aggregation Suppression by Monoterpenoids

  • Liliya E. Nikitina,
  • Roman S. Pavelyev,
  • Ilmir R. Gilfanov,
  • Sergei V. Kiselev,
  • Zulfiya R. Azizova,
  • Alexander A. Ksenofontov,
  • Pavel S. Bocharov,
  • Elena V. Antina,
  • Vladimir V. Klochkov and
  • Ayzira F. Timerova
  • + 9 authors

Platelet aggregation causes various diseases and therefore challenges the development of novel antiaggregatory drugs. In this study, we report the possible mechanism of platelet aggregation suppression by newly synthesized myrtenol-derived monoterpen...

  • Article
  • Open Access
6 Citations
5,163 Views
14 Pages

A deconvolution method is proposed for conduction block (CB) estimation based on two compound muscle action potentials (CMAPs) elicited by stimulating a nerve proximal and distal to the region in which the block is suspected. It estimates the time de...

  • Article
  • Open Access
7 Citations
4,158 Views
19 Pages

CFD-Based and Experimental Hydrodynamic Characterization of the Single-Use Bioreactor XcellerexTM XDR-10

  • Diana Kreitmayer,
  • Srikanth R. Gopireddy,
  • Tomomi Matsuura,
  • Yuichi Aki,
  • Yuta Katayama,
  • Takuya Nakano,
  • Takuma Eguchi,
  • Hirofumi Kakihara,
  • Koichi Nonaka and
  • Thomas Profitlich
  • + 2 authors

Understanding the hydrodynamic conditions in bioreactors is of utmost importance for the selection of operating conditions during cell culture process development. In the present study, the two-phase flow in the lab-scale single-use bioreactor Xcelle...

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Bioengineering - ISSN 2306-5354