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Volume 13
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10.3390/toxics13060468
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Article

Subacute Inhalation Exposure of Mice to Ozone Induces Damage to Various Organs

by
Peiwen Wang
1,2,†,
Yuan Lu
3,4,†,
Kuikui Lu
3,
Daxiao Xie
2,
Min Ling
3,
Luoding Lu
3,
Weiyong Chen
2,
Yu Wu
1,
Qizhan Liu
2,
Qian Bian
3,* and
Tian Xiao
3,*
1
Laboratory of Modern Environmental Toxicology, Environment and Health Research Division, Public Health School and Health Research Centre, Department of Public Health and Preventive Medicine, Wuxi School of Medicine, Jiangnan University, Wuxi 214122, China
2
Center for Global Health, The Key Laboratory of Modern Toxicology, Ministry of Education, School of Public Health, Suzhou Institute of Public Health, Gusu School, Nanjing Medical University, Nanjing 211166, China
3
Institute of Toxicology and Risk Assessment, Jiangsu Province Center of Disease Control and Prevention, Nanjing 210009, China
4
School of Public Health, Xiamen University, Xiamen 361005, China
*
Authors to whom correspondence should be addressed.
†
These authors contributed equally to this work.
Toxics 2025, 13(6), 468; https://doi.org/10.3390/toxics13060468
Submission received: 17 April 2025 / Revised: 23 May 2025 / Accepted: 29 May 2025 / Published: 31 May 2025
(This article belongs to the Section Exposome Analysis and Risk Assessment)
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Abstract

Ambient ozone (O3) pollution, which has become a global problem, is associated with damage to various biological systems, as determined by many studies. However, there is limited experimental evidence regarding the systemic damage induced by O3 exposure, and there are few associated studies on mice. In the present investigation, we constructed a subacute C57BL/6J female mouse model involving exposure to 0, 0.5, 1, or 2 ppm O3 for 28 days (3 h/day). Body weights, pulmonary function, hematology, serum biochemistry, inflammatory factors, and injuries to various organs were assessed for O3-exposed mice. After O3 exposure, especially to 2 ppm O3, mice showed a loss of body weight, abnormal glucose and lipid metabolism, respiratory and nervous system injuries, an inflammatory response, and pathological changes, which supported the data reported for epidemiology studies. In addition, the IL-6 levels in bronchoalveolar lavage fluid (BALF), the lungs, the livers, the kidneys, and the brains were increased, which indicated that IL-6 was associated with the damage to various organs induced by O3 exposure. The present report highlights the pathological injury to various organs and provides a basis for further studies of the molecular mechanisms associated with O3 exposure.
Keywords: ozone pollution; inhalation exposure; multiple organ injury; inflammation and oxidative stress; abnormal glucose and lipid metabolism ozone pollution; inhalation exposure; multiple organ injury; inflammation and oxidative stress; abnormal glucose and lipid metabolism
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MDPI and ACS Style

Wang, P.; Lu, Y.; Lu, K.; Xie, D.; Ling, M.; Lu, L.; Chen, W.; Wu, Y.; Liu, Q.; Bian, Q.; et al. Subacute Inhalation Exposure of Mice to Ozone Induces Damage to Various Organs. Toxics 2025, 13, 468. https://doi.org/10.3390/toxics13060468

AMA Style

Wang P, Lu Y, Lu K, Xie D, Ling M, Lu L, Chen W, Wu Y, Liu Q, Bian Q, et al. Subacute Inhalation Exposure of Mice to Ozone Induces Damage to Various Organs. Toxics. 2025; 13(6):468. https://doi.org/10.3390/toxics13060468

Chicago/Turabian Style

Wang, Peiwen, Yuan Lu, Kuikui Lu, Daxiao Xie, Min Ling, Luoding Lu, Weiyong Chen, Yu Wu, Qizhan Liu, Qian Bian, and et al. 2025. "Subacute Inhalation Exposure of Mice to Ozone Induces Damage to Various Organs" Toxics 13, no. 6: 468. https://doi.org/10.3390/toxics13060468

APA Style

Wang, P., Lu, Y., Lu, K., Xie, D., Ling, M., Lu, L., Chen, W., Wu, Y., Liu, Q., Bian, Q., & Xiao, T. (2025). Subacute Inhalation Exposure of Mice to Ozone Induces Damage to Various Organs. Toxics, 13(6), 468. https://doi.org/10.3390/toxics13060468

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