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Article

Comparison of Postoperative Bleeding between Application of Polyglycolic Acid Sheet and Primary Closure in Tongue Cancer Patients with Partial Glossectomy

Department of Oral and Maxillofacial Surgery, Institute of Clinical Medicine, Faculty of Medicine, University of Tsukuba, 1-1-1 Tennodai, Tsukuba, Ibaraki 305-8575, Japan
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Dent. J. 2020, 8(3), 85; https://doi.org/10.3390/dj8030085
Received: 18 May 2020 / Revised: 7 July 2020 / Accepted: 9 July 2020 / Published: 3 August 2020
(This article belongs to the Special Issue Oral Cancer: Diagnosis and Treatment)
The technique of covering a mucosal defect with fibrin glue and a polyglycolic acid sheet (MCFP) for the resection of mucosa is applied in oral cancers. The MCFP technique for partial glossectomy provides faster relief from postoperative pain and the prevention of scar contracture, unlike primary closure. However, it has a major complication of postoperative bleeding. This study sought to compare postoperative bleeding between the MCFP technique and primary closure. We designed a retrospective study with a cohort of 57 patients who underwent partial glossectomy with the MCFP technique or primary closure. Our primary predictor variable was the wound closure procedure (primary closure or the MCFP technique). The primary outcome variable was postoperative bleeding, and the other variables were patient characteristics, excision area and depth, tooth contact for the wound, and antithrombotic therapy. Statistical evaluation was performed with Pearson’s chi-squared test, Welch’s t-test, and multiple logistic regression. P < 0.05 was considered statistically significant. The MCFP technique was selected for cases with a large excision area (1433 vs. 963 mm2, P = 0.029). Total postoperative bleeding occurred in 10 of 57 patients (MCFP technique: 7 of 37 cases; primary closure: 3 of 20 cases). There was no significant difference in bleeding between the two groups (P = 0.71). Postoperative bleeding was significant in patients with antithrombotic therapy (MCFP: 40% vs. primary closure: 2%, P = 0.0024). Postoperative bleeding timing was significantly different in the MCFP technique (6.4 days) from that of primary closure (1 day; P = 0.0076). Postoperative bleeding was not associated with the MCFP technique or primary closure. However, postoperative bleeding with the MCFP technique occurred later than that with primary closure. The MCFP technique is not recommended for patients on antithrombotic therapy. View Full-Text
Keywords: polyglycolic acid sheet; primary closure; oral cancer; bleeding; partial glossectomy polyglycolic acid sheet; primary closure; oral cancer; bleeding; partial glossectomy
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MDPI and ACS Style

Fukuzawa, S.; Yamagata, K.; Hasegawa, Y.; Ishibashi-Kanno, N.; Uchida, F.; Yanagawa, T.; Bukawa, H. Comparison of Postoperative Bleeding between Application of Polyglycolic Acid Sheet and Primary Closure in Tongue Cancer Patients with Partial Glossectomy. Dent. J. 2020, 8, 85. https://doi.org/10.3390/dj8030085

AMA Style

Fukuzawa S, Yamagata K, Hasegawa Y, Ishibashi-Kanno N, Uchida F, Yanagawa T, Bukawa H. Comparison of Postoperative Bleeding between Application of Polyglycolic Acid Sheet and Primary Closure in Tongue Cancer Patients with Partial Glossectomy. Dentistry Journal. 2020; 8(3):85. https://doi.org/10.3390/dj8030085

Chicago/Turabian Style

Fukuzawa, Satoshi, Kenji Yamagata, Yuuma Hasegawa, Naomi Ishibashi-Kanno, Fumihiko Uchida, Toru Yanagawa, and Hiroki Bukawa. 2020. "Comparison of Postoperative Bleeding between Application of Polyglycolic Acid Sheet and Primary Closure in Tongue Cancer Patients with Partial Glossectomy" Dentistry Journal 8, no. 3: 85. https://doi.org/10.3390/dj8030085

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