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Inorganics, Volume 8, Issue 7

July 2020 - 3 articles

Cover Story: The link between the biosynthesis and maturation of molybdoenzymes and the biosynthesis and distribution of Fe-S clusters is highlighted. Both molybdenum (moco) biosynthesis and Fe-S cluster assembly are highly conserved among all kingdoms of life. In all organisms, Fe-S cluster assembly starts with the abstraction of sulfur from L-cysteine and its transfer to a scaffold protein. After formation, Fe-S clusters are transferred to carrier proteins that insert them into recipient apo-proteins. Moco biosynthesis begins with a Fe-S cluster-dependent step, involving radical/S-adenosylmethionine (SAM) chemistry in the first step—the conversion of 5’-GTP to cyclic pyranopterin monophosphate (cPMP). Moco is a tricyclic pterin compound with molybdenum coordinated through its unique dithiolene group. View this paper.
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Articles (3)

  • Review
  • Open Access
9 Citations
6,010 Views
23 Pages
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The Requirement of Inorganic Fe-S Clusters for the Biosynthesis of the Organometallic Molybdenum Cofactor

  • Ralf R. Mendel,
  • Thomas W. Hercher,
  • Arkadiusz Zupok,
  • Muhammad A. Hasnat and
  • Silke Leimkühler
Inorganics2020, 8(7), 43;https://doi.org/10.3390/inorganics8070043

16 July 2020

Iron-sulfur (Fe-S) clusters are essential protein cofactors. In enzymes, they are present either in the rhombic [2Fe-2S] or the cubic [4Fe-4S] form, where they are involved in catalysis and electron transfer and in the biosynthesis of metal-containin...

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  • Article
  • Open Access
8 Citations
3,653 Views
10 Pages
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In Vitro Evaluation of a Peptide-Mesoporous Silica Nanoparticle Drug Release System against HIV-1

  • Katharina Braun,
  • Christina M. Stürzel,
  • Frank Kirchhoff and
  • Mika Lindén
Inorganics2020, 8(7), 42;https://doi.org/10.3390/inorganics8070042

13 July 2020

It has been shown that the optimized VIR-576 derivative of the natural HIV-1 entry inhibitor targeting the viral gp41 fusion peptide is safe and effective in infected individuals. However, high doses of this peptide were required, and stability, as w...

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  • Review
  • Open Access
7 Citations
4,219 Views
13 Pages
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Structure: Function Studies of the Cytosolic, Mo- and NAD+-Dependent Formate Dehydrogenase from Cupriavidus necator

  • Russ Hille,
  • Tynan Young,
  • Dimitri Niks,
  • Sheron Hakopian,
  • Timothy K. Tam,
  • Xuejun Yu,
  • Ashok Mulchandani and
  • Gregor M. Blaha
Inorganics2020, 8(7), 41;https://doi.org/10.3390/inorganics8070041

6 July 2020

Here, we report recent progress our laboratories have made in understanding the maturation and reaction mechanism of the cytosolic and NAD+-dependent formate dehydrogenase from Cupriavidus necator. Our recent work has established that the enzyme is f...

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