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Volume 5
Issue 3
10.11599/germs.2015.1076
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GERMS is published by MDPI from Volume 25 Issue 4 (2025). Previous articles were published by another publisher in Open Access under a CC-BY (or CC-BY-NC-ND) licence, and they are hosted by MDPI on mdpi.com as a courtesy and upon agreement with the former publisher Infection Science Forum S.R.L..
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Article

Leptin Expression in HIV-Infected Patients During Antiretroviral Therapy

by
Cătălin Tiliscan
1,2,*,
Victoria Aramă
1,2,
Raluca Mihăilescu
2,
Daniela Ioana Munteanu
2,
Adrian Streinu-Cercel
1,2,
Daniela Adriana Ion
1,
Mihaela Andreea Rădulescu
1,2,
Cristina Popescu
1,2,
Alina Elena Lobodan
1,2,
Anca Ruxandra Negru
1,2 and
Ștefan Sorin Aramă
1
1
Carol Davila University of Medicine and Pharmacy, Bucharest, Romania
2
National Institute for Infectious Diseases "Prof.Dr. Matei Balş”, Bucharest, Romania
*
Author to whom correspondence should be addressed.
GERMS 2015, 5(3), 92-98; https://doi.org/10.11599/germs.2015.1076
Submission received: 21 June 2015 / Revised: 25 August 2015 / Accepted: 1 September 2015 / Published: 1 September 2015
Versions Notes

Abstract

Background: Leptin is an adipokine with complex metabolic, neuroendocrine and immune functions. Our objective was to evaluate leptin serum levels in a cohort of Romanian HIV‐infected patients undergoing antiretroviral therapy in relation to their immune‐virological status, lipid and glucose metabolic abnormalities and the presence of metabolic syndrome (MS). Methods: We enrolled consecutive non‐diabetic HIV‐infected patients aged 18 and over on stable cART for at least 6 months. Blood samples were tested for: leptin, CD4 T cells count, HIV viral load and lipid panel. Results: A total of 90 HIV‐infected patients were included in the study: 50 males (55.6%) with a mean age of 33.3 years and 40 females with a mean age of 30.4 years. Most patients (74.4%) had HIV viral load below the limit of detection and the median CD4 count for the cohort was 476 (410) cells/cmm. More than one third of the patients (41.1%) had hypoleptinemia. The prevalence of MS was 13.3%. Hypoleptinemia was significantly more frequent in men. In a subset of patients with undetectable HIV viral load, the median leptin value was 0.6 (6.07) ng/mL in patients with poor immune recovery (CD4 count ≤ 200/cmm) compared to 2 (3.07) ng/mL for those with better immune response (CD4 count > 200/cmm), without statistical significance. The median values of leptin were similar for persons with and without MS criteria. HDL‐cholesterol values were positively correlated to leptin values in a linear regression model. Conclusion: A significant proportion of patients in our study presented low levels of leptin; this finding was not associated with immune and virological parameters or the presence of MS. Hypoleptinemia was significantly correlated with lower levels of HDL‐cholesterol, a key cardiovascular risk factor.
Keywords: leptin; HIV; antiretroviral therapy; HDL‐cholesterol leptin; HIV; antiretroviral therapy; HDL‐cholesterol

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MDPI and ACS Style

Tiliscan, C.; Aramă, V.; Mihăilescu, R.; Munteanu, D.I.; Streinu-Cercel, A.; Ion, D.A.; Rădulescu, M.A.; Popescu, C.; Lobodan, A.E.; Negru, A.R.; et al. Leptin Expression in HIV-Infected Patients During Antiretroviral Therapy. GERMS 2015, 5, 92-98. https://doi.org/10.11599/germs.2015.1076

AMA Style

Tiliscan C, Aramă V, Mihăilescu R, Munteanu DI, Streinu-Cercel A, Ion DA, Rădulescu MA, Popescu C, Lobodan AE, Negru AR, et al. Leptin Expression in HIV-Infected Patients During Antiretroviral Therapy. GERMS. 2015; 5(3):92-98. https://doi.org/10.11599/germs.2015.1076

Chicago/Turabian Style

Tiliscan, Cătălin, Victoria Aramă, Raluca Mihăilescu, Daniela Ioana Munteanu, Adrian Streinu-Cercel, Daniela Adriana Ion, Mihaela Andreea Rădulescu, Cristina Popescu, Alina Elena Lobodan, Anca Ruxandra Negru, and et al. 2015. "Leptin Expression in HIV-Infected Patients During Antiretroviral Therapy" GERMS 5, no. 3: 92-98. https://doi.org/10.11599/germs.2015.1076

APA Style

Tiliscan, C., Aramă, V., Mihăilescu, R., Munteanu, D. I., Streinu-Cercel, A., Ion, D. A., Rădulescu, M. A., Popescu, C., Lobodan, A. E., Negru, A. R., & Aramă, Ș. S. (2015). Leptin Expression in HIV-Infected Patients During Antiretroviral Therapy. GERMS, 5(3), 92-98. https://doi.org/10.11599/germs.2015.1076

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