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Stimuli-Sensitive Cell Penetrating Peptide-Modified Nanocarriers

Centre de Biophysique Moléculaire, UPR CNRS 4301, Rue Charles Sadron, Orléans, 45071 CEDEX 2, France
Processes 2019, 7(10), 727; https://doi.org/10.3390/pr7100727
Received: 6 September 2019 / Revised: 25 September 2019 / Accepted: 30 September 2019 / Published: 11 October 2019
(This article belongs to the Section Biological Systems)
The integration of drugs into nanocarriers favorably altered their pharmacodynamics and pharmacokinetics compared to free drugs, and increased their therapeutic index. However, selective cellular internalization in diseased tissues rather than normal tissues still presents a formidable challenge. In this chapter I will cover solutions involving environment-responsive cell-penetrating peptides (CPPs). I will discuss properties of CPPs as universal cellular uptake enhancers, and the modifications imparted to CPP-modified nanocarriers to confine CPP activation to diseased tissues.
Keywords: peptides; cellular uptake; responsive peptides; cellular uptake; responsive
MDPI and ACS Style

Perche, F. Stimuli-Sensitive Cell Penetrating Peptide-Modified Nanocarriers. Processes 2019, 7, 727.

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