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Biomedicines, Volume 11, Issue 9

September 2023 - 263 articles

Cover Story: Stiff person spectrum disorders (SPSD) are paradigm autoimmune movement disorders characterized by stiffness, spasms, and hyperekplexia. Though rare, SPSD represent a not-to-miss diagnosis because of the associated disease burden and treatment implications. Major advances in our understanding of the evolving spectrum of diseases have been made along with the identification of multiple associated autoantibodies. However, the most important recent developments relate to the recognition of a wider affection, beyond the classic core motor symptoms, and further insights into immunomodulatory and symptomatic therapies. In this review, we summarize the recent literature on the clinical and paraclinical spectrum, current pathophysiological understanding, as well as current and possible future therapeutic strategies. View this paper
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Articles (263)

  • Article
  • Open Access
3 Citations
2,929 Views
23 Pages

Oils from Transgenic Flax Lines as Potential Chemopreventive Agents in Colorectal Cancer

  • Tomasz Gębarowski,
  • Benita Wiatrak,
  • Izabela Jęśkowiak-Kossakowska,
  • Magdalena Grajzer and
  • Anna Prescha

21 September 2023

Colorectal cancer is a major global health concern, and the need for effective chemopreventive agents is paramount. This study aimed to evaluate the potential of oils from transgenically modified flax for the prevention of colorectal cancer, in relat...

  • Article
  • Open Access
1,596 Views
14 Pages

Angiogenin Levels and Carotid Intima-Media Thickness in Patients with Type 1 Diabetes and Metabolic Syndrome

  • Jolanta Neubauer-Geryk,
  • Melanie Wielicka,
  • Grzegorz M. Kozera and
  • Leszek Bieniaszewski

21 September 2023

It is well documented that in patients with type 1 diabetes (DM1), decreased levels of angiogenin are associated with the development of overt nephropathy. However, little is known about angiogenin levels and subclinical macrovascular organ damage in...

  • Review
  • Open Access
34 Citations
4,967 Views
16 Pages

21 September 2023

The interplay between adipokines and pancreatic beta cells, often referred to as the adipo-insular axis, plays a crucial role in regulating metabolic homeostasis. Adipokines are signaling molecules secreted by adipocytes that have profound effects on...

  • Article
  • Open Access
1 Citations
4,223 Views
13 Pages

Effects of Myofascial Induction Therapy on Ankle Range of Motion and Pressure Pain Threshold in Trigger Points of the Gastrocnemius—A Clinical Trial

  • Eva María Martínez-Jiménez,
  • Raquel Jiménez-Fernández,
  • Inmaculada Corral-Liria,
  • David Rodríguez-Sanz,
  • César Calvo-Lobo,
  • Daniel López-López,
  • Eduardo Pérez-Boal,
  • Bibiana Trevissón-Redondo and
  • Jessica Grande-del-Arco

21 September 2023

Background: The myofascial induction technique (MIT) has been shown to increase shoulder range of motion (ROM) in breast cancer survivors and decrease pain pressure threshold over the radial nerve in patients with epicondylalgia. To the authors&rsquo...

  • Article
  • Open Access
2 Citations
2,119 Views
18 Pages

Characterization of Distinct Chondrogenic Cell Populations of Patients Suffering from Microtia Using Single-Cell Micro-Raman Spectroscopy

  • Dominika Zielinska,
  • Hesham K. Yosef,
  • Tilo Zollitsch,
  • Johann Kern,
  • Yvonne Jakob,
  • David Gvaramia,
  • Nicole Rotter,
  • Luca Pontiggia,
  • Ueli Moehrlen and
  • Thomas Biedermann
  • + 1 author

21 September 2023

Microtia is a congenital condition of abnormal development of the outer ear. Tissue engineering of the ear is an alternative treatment option for microtia patients. However, for this approach, the identification of high regenerative cartilage progeni...

  • Review
  • Open Access
66 Citations
12,804 Views
14 Pages

NF-κB Pathway and Its Inhibitors: A Promising Frontier in the Management of Alzheimer’s Disease

  • Bhagavathi Sundaram Sivamaruthi,
  • Neha Raghani,
  • Mehul Chorawala,
  • Sankha Bhattacharya,
  • Bhupendra G. Prajapati,
  • Gehan M. Elossaily and
  • Chaiyavat Chaiyasut

21 September 2023

The nuclear factor kappa B (NF-κB) pathway has emerged as a pivotal player in the pathogenesis of various diseases, including neurodegenerative illnesses like Alzheimer’s disease (AD). The involvement of the NF-κB pathway in immune...

  • Review
  • Open Access
4 Citations
4,829 Views
11 Pages

Clinical Approaches to Nestorone Subdermal Implant Therapy in Women’s Health

  • Guilherme Renke,
  • Consuelo Callizo,
  • Raphaela Paes,
  • Mariana Antunes,
  • Glaycon Michels,
  • Luana Concha,
  • Ordânio Almeida,
  • Christiane Valente,
  • Thomaz Baesso and
  • Bruna Giovannoni

21 September 2023

Segesterone acetate (SA) or Nestorone, a fourth-generation progestogen, is a synthetic compound with high progestational activity and no androgenic, glucocorticoid, or anabolic effects. However, due to its oral inactivity, SA must be used by other ro...

  • Article
  • Open Access
4 Citations
2,170 Views
13 Pages

The Effects of Adiponectin on the Behavior of B-Cell Leukemia Cells: Insights from an In Vitro Study

  • Marta Mallardo,
  • Giulia Scalia,
  • Maddalena Raia,
  • Aurora Daniele and
  • Ersilia Nigro

21 September 2023

Background: Non-Hodgkin’s lymphoma (NHL), the most frequent hematological neoplasm worldwide, represents a heterogeneous group of malignancies. The etiology of NHL remains to be fully elucidated, but the role of adipose tissue (AT) in immune fu...

  • Article
  • Open Access
2,091 Views
12 Pages

Clinical Characteristics and Outcomes of Patients Hospitalized with Epidermolysis Bullosa: A Retrospective Population-Based Observational Study in Spain (2016–2021)

  • Natividad Cuadrado-Corrales,
  • Ana Lopez-de-Andres,
  • Valentín Hernández-Barrera,
  • David Carabantes-Alarcon,
  • Jose J. Zamorano-Leon,
  • Ricardo Omaña-Palanco,
  • Jose L. Del-Barrio,
  • Javier De-Miguel-Díez,
  • Rodrigo Jimenez-Garcia and
  • Juan J. Montoya

20 September 2023

(1) Background: Epidermolysis bullosa (EB) comprises a group of rare skin diseases. We assessed diagnostic procedures, comorbidity profiles, length of hospital stay (LOHS), costs, and in-hospital mortality (IHM) associated with EB. (2) Methods: A ret...

  • Review
  • Open Access
19 Citations
3,898 Views
13 Pages

MicroRNA-21 Silencing in Diabetic Nephropathy: Insights on Therapeutic Strategies

  • Yogita Dhas,
  • Numair Arshad,
  • Nupur Biswas,
  • Lawrence D. Jones and
  • Shashaanka Ashili

20 September 2023

In diabetes, possibly the most significant site of microvascular damage is the kidney. Due to diabetes and/or other co-morbidities, such as hypertension and age-related nephron loss, a significant number of people with diabetes suffer from kidney dis...

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Biomedicines - ISSN 2227-9059