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Article

Health-Related Quality of Life and Mental Health after Surgical Treatment of Hepatocellular Carcinoma in the Era of Minimal-Invasive Surgery: Resection versus Transplantation

by
Linda Feldbrügge
1,*,
Alexander Langenscheidt
1,
Felix Krenzien
1,
Mareike Schulz
1,
Nicco Krezdorn
2,
Kaan Kamali
1,
Andreas Hinz
3,
Michael Bartels
4,
Panagiotis Fikatas
1,
Moritz Schmelzle
1,
Johann Pratschke
1 and
Christian Benzing
1
1
Department of Surgery, Campus Charité-Mitte and Campus Virchow Klinikum, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, 13353 Berlin, Germany
2
Department of Plastic, Hand and Reconstructive Surgery, Hannover Medical School, 30625 Hannover, Germany
3
Department of Medical Psychology and Medical Sociology, University Hospital Leipzig, 04103 Leipzig, Germany
4
Department of General, Visceral and Thoracic Surgery, Helios Park-Klinikum Leipzig, 04103 Leipzig, Germany
*
Author to whom correspondence should be addressed.
Healthcare 2021, 9(6), 694; https://doi.org/10.3390/healthcare9060694
Submission received: 3 May 2021 / Revised: 30 May 2021 / Accepted: 2 June 2021 / Published: 9 June 2021
(This article belongs to the Special Issue Minimally Invasive Techniques and Advanced Surgical Procedures)
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Abstract

Laparoscopic liver resection (LLR) is an increasingly relevant treatment option for patients with resectable hepatocellular carcinoma (HCC). Orthotopic liver transplantation (OLT) has been considered optimal treatment for HCC in cirrhosis, but is challenged by rising organ scarcity. While health-related quality of life (HRQoL) and mental health are well-documented after OLT, little is known about HRQoL in HCC patients after LLR. We identified all HCC patients who underwent LLR at our hospital between 2014 and 2018. HRQoL and mental health were assessed using the Short Form 36 and the Hospital Anxiety and Depression Scale, respectively. Outcomes were compared to a historic cohort of HCC patients after OLT. Ninety-eight patients received LLR for HCC. Postoperative morbidity was 25% with 17% minor complications. LLR patients showed similar overall HRQoL and mental health to OLT recipients, except for lower General Health (p = 0.029) and higher anxiety scores (p = 0.010). We conclude that LLR can be safely performed in patients with HCC, with or without liver cirrhosis. The postoperative HRQoL and mental health are comparable to that of OLT recipients in most aspects. LLR should thus always be considered an alternative to OLT, especially in times of organ shortage.
Keywords: hepatocellular carcinoma; minimally invasive liver surgery; health-related quality of life; liver transplantation hepatocellular carcinoma; minimally invasive liver surgery; health-related quality of life; liver transplantation

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MDPI and ACS Style

Feldbrügge, L.; Langenscheidt, A.; Krenzien, F.; Schulz, M.; Krezdorn, N.; Kamali, K.; Hinz, A.; Bartels, M.; Fikatas, P.; Schmelzle, M.; et al. Health-Related Quality of Life and Mental Health after Surgical Treatment of Hepatocellular Carcinoma in the Era of Minimal-Invasive Surgery: Resection versus Transplantation. Healthcare 2021, 9, 694. https://doi.org/10.3390/healthcare9060694

AMA Style

Feldbrügge L, Langenscheidt A, Krenzien F, Schulz M, Krezdorn N, Kamali K, Hinz A, Bartels M, Fikatas P, Schmelzle M, et al. Health-Related Quality of Life and Mental Health after Surgical Treatment of Hepatocellular Carcinoma in the Era of Minimal-Invasive Surgery: Resection versus Transplantation. Healthcare. 2021; 9(6):694. https://doi.org/10.3390/healthcare9060694

Chicago/Turabian Style

Feldbrügge, Linda, Alexander Langenscheidt, Felix Krenzien, Mareike Schulz, Nicco Krezdorn, Kaan Kamali, Andreas Hinz, Michael Bartels, Panagiotis Fikatas, Moritz Schmelzle, and et al. 2021. "Health-Related Quality of Life and Mental Health after Surgical Treatment of Hepatocellular Carcinoma in the Era of Minimal-Invasive Surgery: Resection versus Transplantation" Healthcare 9, no. 6: 694. https://doi.org/10.3390/healthcare9060694

APA Style

Feldbrügge, L., Langenscheidt, A., Krenzien, F., Schulz, M., Krezdorn, N., Kamali, K., Hinz, A., Bartels, M., Fikatas, P., Schmelzle, M., Pratschke, J., & Benzing, C. (2021). Health-Related Quality of Life and Mental Health after Surgical Treatment of Hepatocellular Carcinoma in the Era of Minimal-Invasive Surgery: Resection versus Transplantation. Healthcare, 9(6), 694. https://doi.org/10.3390/healthcare9060694

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