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4 November 2026

46 Pages

Supporting Social and Communication Outcomes in Children with Autism Spectrum Disorder via Mobile Device-Based Interventions: A Systematic Review

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and
1
Department of Management Science and Technology, University of Patras, 26334 Patras, Greece
2
Department of Special Education, University of Thessaly, 38221 Volos, Greece
*
Author to whom correspondence should be addressed.

Abstract

Children diagnosed with Autism Spectrum Disorder (ASD) often encounter significant challenges in social interaction and communication. The integration of portable devices (e.g., mobile phones and tablets) into educational frameworks is transforming the support landscape for students with ASD, with these devices serving as feasible and potentially advantageous delivery platforms for interventions targeting selected, directly trained outcomes. The objectives of this review are threefold: (a) to synthesize peer-reviewed research regarding the use of portable devices to enhance social skills in children with ASD; (b) to evaluate and analyze the efficacy of these digital interventions; (c) to identify current limitations in the literature while providing evidence-based recommendations for practitioners, educators, and future research. The review was conducted and reported in accordance with the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) guidelines. A systematic search was conducted using the following electronic databases: (a) PsycINFO, (b) Education Resources Information Center (ERIC), (c) Scopus, and (d) Web of Science. Fourteen studies were included, comprising a total of 201 children: 154 children with ASD and 47 typically developing children who served as an active control group in one study. Ten studies employed single-case experimental designs, whereas four used group-based research designs. Given the heterogeneity in study designs and outcome measures, the findings were synthesized narratively rather than through a meta-analysis. Data on intervention components, implementation strategies, and outcomes were extracted. The findings indicate that portable devices may offer a feasible and potentially advantageous means of delivering interventions for selected, directly trained outcomes in children with ASD; however, the strength and consistency of the evidence varied across studies and research designs. Several studies reported improvements in targeted communication, social–emotional, and interpersonal outcomes, whereas evidence regarding the generalization and maintenance of these improvements remained comparatively limited. The current evidence base does not support firm conclusions regarding their overall effectiveness in improving social skills. The available literature also exhibits considerable variability in sample sizes, study designs, outcome measures, and follow-up durations. Future research should prioritize rigorous designs, including studies with larger samples and long-term follow-up to assess the sustainability of outcomes.

1. Introduction

According to the Centers for Disease Control and Prevention (CDC), the national public health agency of the United States, approximately 1 in 31 (3.2%) eight-year-old children have been diagnosed with Autism Spectrum Disorder (ASD) (Shaw et al., 2025), with boys being approximately four times more likely to be affected than girls (Abdul Hakim et al., 2021; Berenguer et al., 2020; Miningrum et al., 2021). Children with ASD commonly experience significant difficulties in social interaction, largely attributable to deficits in social functioning (American Psychiatric Association, 2013).
The construct of social skills encompasses a set of learned behaviors that enable individuals to engage effectively in social interactions. It reflects a dynamic process involving the individual, the communicative intent, and the surrounding social context. More specifically, social skills comprise behaviors that facilitate adaptive interpersonal engagement, as well as the regulation and avoidance of socially inappropriate responses (Moosapoor, 2023). Furthermore, these skills involve the capacity to navigate situational demands that elicit and sustain social interaction, thereby requiring a degree of social competence. Intervention outcomes in this field span a range of developmental domains, reflecting the multifaceted nature of children’s social, communicative, and cognitive functioning. For the purposes of the present review, the social skill outcomes identified across the included studies were subsequently grouped into three broad domains to facilitate their organization and synthesis. The first domain, communication and pragmatic language, encompasses the functional use of language in social contexts, including requesting, question answering and conversational responding, as well as prosody. The second domain, social–emotional and interpersonal skills, includes abilities related to understanding and engaging with others, such as emotion recognition, understanding social norms, and social engagement. The third domain, cognitive and pre-academic skills, includes foundational abilities that support learning and communication, such as receptive vocabulary, defined as the comprehension of spoken words and language. This taxonomy provides a structured framework for examining intervention outcomes across studies.
A central barrier to the development of social skills in children with ASD lies in the communication difficulties that permeate their everyday experiences. These individuals are significantly less likely to initiate social interactions (Pavlou & Garmpis, 2025), a pattern largely driven by impairments in joint attention and peer engagement, which constitute foundational mechanisms of early social reciprocity. Such disruptions may compromise social orienting, resulting in reduced responsiveness to social cues and the impression of diminished awareness of others. Consequently, limitations in initiating and sustaining reciprocal play emerge, restricting opportunities for meaningful peer engagement and thereby impeding the formation and maintenance of stable social relationships (Kasari & Patterson, 2012). In addition, communication in ASD is often characterized by atypical prosodic features, including variations in intensity, rhythm, speech rate, and intonation patterns (Qualls & Corbett, 2017). Within this context, social routines assume a critical role. Such routines consist of structured, mutually engaging activities between two or more individuals, during which the child’s attention is directed toward the social partner or the interaction itself rather than toward objects (Rogers & Dawson, 2010). When these routines are experienced as intrinsically rewarding, they can provide meaningful context for the acquisition and generalization of social communication skills (Ramseur et al., 2019).
Another domain that substantially influences everyday social functioning is that of social norms. These norms constitute implicit regulatory frameworks that govern behavior within a social group. They play a pivotal role in shaping actions, cognitive processes, and interpersonal interactions by establishing shared expectations regarding acceptable and non-compliant behavior. Understanding the mechanisms through which such norms emerge and exert influence is essential for a comprehensive account of social functioning (Costescu et al., 2025). Children with ASD are less likely to conform to social norms compared to their typically developing peers, which may hinder their ability to interpret social cues and pose challenges in the formation and maintenance of peer relationships (Yafai et al., 2014).
Language development represents another critical factor influencing communication outcomes in children with ASD (A. S. Chan et al., 2005). Early interventions targeting language acquisition—particularly during the preschool years—have been shown to significantly enhance linguistic competencies. Indeed, the implementation of early behavioral interventions is associated with more favorable developmental trajectories, including improvements in social adaptation, communication skills, and subsequent language development (Hesami et al., 2025). In the broader preschool population, speech and language development has also been positively associated with school readiness, underscoring the developmental importance of early language skills (Koçak & Korkmaz, 2023).
Importantly, the development of language skills alone is insufficient; their functional use is equally essential. Functional language encompasses the ability to express needs through requests, respond appropriately to questions, recognize opportunities for turn-taking, and engage in increasingly complex verbal behaviors. These competencies collectively contribute to both social and cognitive development (Ganz et al., 2017).
Within the domains of linguistics and speech–language pathology, the term receptive lexicon refers to the set of words an individual can comprehend through listening or reading, even in the absence of active production. Children with ASD often exhibit difficulties in acquiring new vocabulary (Pickles et al., 2014), which may constrain lexical development and, in turn, negatively affect social functioning (El Shemy et al., 2025). It is estimated that approximately 25% to 30% of children with autism do not develop sufficient spoken language to meet their daily communication needs (Rose et al., 2016). Consequently, in the absence of targeted and effective intervention, these individuals may reach adulthood with limited communicative autonomy, leading to persistent challenges in social interaction, employment opportunities, and community participation (Light et al., 2019).
Finally, the functional use of language is closely intertwined with the development of social–emotional competencies. Interventions targeting social–emotional functioning aim to address core deficits associated with ASD, with the goal of enhancing both social understanding and emotional regulation (Nuske et al., 2024). Children with ASD frequently exhibit impairments in social–emotional processing, including difficulties in emotion recognition and in understanding and responding appropriately to social interactions (American Psychiatric Association, 2013). These deficits in social–emotional reciprocity can affect both emotional expression and broader patterns of social engagement (Lyu et al., 2024). Promoting inclusion remains a central objective in efforts to enhance social skills, as inclusive environments provide children with opportunities to participate meaningfully, engage in the learning process, and pursue individualized developmental goals (Papazoglou et al., 2021).

ASD and Portable Devices

Children on the autism spectrum appear to demonstrate a distinct preference for digital technologies, a tendency that has been attributed to their affinity for structured, predictable, and discrete forms of information processing (Terlouw et al., 2020). However, this should be understood as a potential preference for the organization and accessibility of digital media rather than as a general preference for digital communication over face-to-face social interaction. The integration of technological tools into educational contexts has expanded the range of intervention approaches available to students with developmental disabilities, with digital technologies potentially serving as feasible platforms for delivering targeted instructional interventions. (Alzyoudi & Alghazali, 2025).
Interventions targeting communication and social–emotional development through the use of computer-based technologies are becoming increasingly prevalent, with a growing body of evidence indicating positive outcomes. These digital interventions have been investigated as potential tools to support core developmental domains, although reported outcomes vary across intervention types and study designs (Ramdoss et al., 2012). Empirical findings further underscore the potential of such approaches to improve both communication and social–emotional skills in children with ASD (Boyd et al., 2015; Garcia-Garcia et al., 2022; Jain et al., 2012).
Portable devices, including mobile phones and tablets, constitute a central component of contemporary digital technologies due to their distinctive affordances that enhance usability and accessibility. These affordances include portability, compact design, multimodal information presentation, and intuitive interfaces. These digital interventions have been investigated as potential tools for supporting core developmental domains, although reported outcomes vary across intervention types and study designs (Vlachou & Drigas, 2017).
Moreover, portable devices facilitate communication through the use of visual supports, such as symbols, images, and written text. Research suggests that children with ASD show a marked preference for such modalities (Aydin & Diken, 2020), likely due to their responsiveness to structured and visually organized environments (Travers & Fefer, 2017). Within this context, tablet-based interventions—particularly those utilizing iPads—have been shown to significantly enhance communication abilities, enabling children to express their needs more effectively and to participate more meaningfully in social interactions (Dundon et al., 2013).
Furthermore, evidence indicates that the use of such devices may contribute to a reduction in communication-related challenging behaviors, primarily through the enhancement of functional communication and social engagement, thereby supporting broader social development (Xin & Leonard, 2015). However, it is essential that the implementation of these technologies be guided by clearly defined criteria and tailored to the individualized needs of each learner, thereby enhancing their effectiveness (Achtypi & Papoudi, 2024).
Beyond serving as platforms for intervention delivery, digital technologies may also influence how users process and respond to information. From the perspectives of technological cognition and transactive technical cognition, mobile-device interventions may involve not only child–device interactions but also socially distributed processes involving caregivers, parents, teachers, or therapists. This distinction is important because outcomes observed in adult-supported interventions cannot necessarily be attributed solely to the digital interface.
Previous reviews have addressed related but distinct aspects of mobile technology use in individuals with ASD. Leung et al. (2021) synthesized randomized controlled trials of mobile-device interventions targeting social and cognitive skills individuals with ASD of different age groups, with the included literature extending to 2019. Hussain et al. (2021) focused on educational mobile applications for children with ASD, particularly their use by teachers to support language and communication skills. More recently, Toma et al. (2024) examined extended-reality-based mobile applications for children with ASD from a predominantly technical and information technology (IT)-oriented perspective, with a specific focus on AR, VR, and MR technologies. Notably, some of the included applications were evaluated only by developers rather than directly with children. Taken together, these reviews suggest the value for an updated synthesis of recent mobile phone- and tablet-based interventions addressing social and communication-related outcomes in children across multiple intervention modalities and heterogeneous research designs.
The present review offers a complementary contribution by providing an updated, child-focused synthesis of studies published between 2020 and 2025, focusing specifically on interventions in which smartphones or tablets served as the primary intervention delivery medium. It integrates contemporary intervention approaches delivered through mobile devices across heterogeneous research designs and outcome domains. Methodologically, the review applies complementary quality appraisal approaches using the MMAT and the SCED Scale, allowing methodological characteristics to be evaluated according to the design-specific requirements of each study type. The review also extends previous work by systematically examining the social validity of the included interventions. In addition, the review reports available information regarding financial support of the included studies to improve transparency regarding potential contextual factors influencing the evidence base. Furthermore, by identifying which interventions employed commercially available applications, the review provides a practical overview of tools that can be accessed and considered by educators, practitioners, and caregivers, subject to their evidence base, suitability, and the individual needs of each child.

2. Methodology

The present review employed a systematic search strategy and was conducted and reported in accordance with the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) guidelines. The corresponding PRISMA checklist was completed and is provided in Appendix B. In accordance with PRISMA guidelines, the review was guided by the following focused question: “Do interventions using portable devices enhance social skills in children with ASD?” The review was not registered, and a formal review protocol was not prepared.

2.1. Search Process

A systematic search was conducted across four electronic databases: (a) PsycINFO, (b) Education Resources Information Center (ERIC), (c) Scopus, and (d) Web of Science. Database research was conducted iteratively across PsycINFO, ERIC, Scopus, and Web of Science between summer 2025 and February 2026. The eligibility period was restricted to studies published through December 2025. Exact database-specific search dates were not recorded contemporaneously. These databases were selected to reflect the interdisciplinary yet predominantly educational and psychological focus of the review. ERIC provides specialized coverage of educational research, whereas PsycINFO indexes literature across psychology and the behavioral and social sciences. Scopus and Web of Science were included to provide broader multidisciplinary coverage spanning education, psychology, social sciences, health-related research, and technology. This combination of databases has also been used in previous systematic reviews addressing assistive technology, disability, and autism-related educational outcomes. Databases with a predominant biomedical or technical-computing focus were not searched because the present review aimed to synthesize child-focused social and communication interventions rather than biomedical treatment or technology-development research.
Titles and abstracts of all retrieved records were screened for relevance. The search strategy incorporated the following terms: “Autism” AND (“apps” OR “mobile” OR “tablet” OR “iPad” OR “mobile devices”) AND “social skills”. Studies published between January 2020, and December 2025 were considered eligible, to ensure the inclusion of the most recent evidence in the field of autism research. The selected time frame also complements previous reviews that included earlier technological interventions by focusing specifically on contemporary mobile-device applications. The review process was conducted rigorously and involved critical evaluation by all authors. No automation tools were used at any stage of the review.
The search strategy was intentionally designed to identify studies in which mobile phones or tablets constituted the principal intervention delivery platform. Consequently, intervention-specific approaches such as Augmentative and Alternative Communication, Speech-Generating Devices, Social Stories, Augmented Reality, Serious Games were considered eligible only when implemented through mobile devices and when social skill outcomes satisfied the predefined eligibility criteria.

2.2. Inclusion and Exclusion Criteria

This study aimed to examine the effects of mobile application–based interventions on the social skills of children with ASD. The inclusion criteria for eligible studies were defined as follows: (a) participants had a formal diagnosis of ASD; (b) participants did not present with comorbid conditions (e.g., Tourette syndrome, visual impairments, hearing loss, attention-deficit/hyperactivity disorder [ADHD]); (c) studies were published in peer-reviewed scientific journals or conference proceedings; (d) participants were involved in an intervention incorporating at least one mobile application; (e) the intervention explicitly targeted social skills; (f) studies were published between January 2020 and December 2025; (g) participants were between 2 and 12 years of age.
Studies were excluded if they: (a) were not published in English; (b) did not involve the use of at least one mobile application; or (c) included participants outside the specified age range; (d) pilot studies; (e) were books and reviews. The focus on recent, peer-reviewed publications written in English was intended to capture recent, rapidly evolving evidence. The selected age range was chosen to capture interventions targeting preschool and primary school populations, as intervention approaches for adolescents may differ substantially and warrant separate investigation. Three pilot studies were excluded from the systematic review due to significant methodological and operational limitations. Lee et al. (2023) was omitted due to technical constraints during data acquisition and evaluation. Specifically, storage limitations precluded the execution of the primary protocol for biometric data collection via webcams and wearable devices. The resulting absence of webcam timestamp data restricted the depth of the subsequent analysis. Drapalik et al. (2022) was excluded because its internal validity was compromised by sparse demographic data and a high attrition rate, the latter of which was particularly pronounced within the control group. Safi et al. (2022) presented compromised intervention consistency, as participant absenteeism resulted in multiple missed sessions. Furthermore, adaptations to the research design mandated by the COVID-19 pandemic introduced confounding variables and diminished overall methodological rigor.
For the purposes of this review, the broad outcome domain of social skills constituted an eligibility criterion. Studies were considered eligible when the intervention explicitly targeted social skills and when mobile phones or tablets served as the intervention delivery medium. Studies that did not target social skills or in which mobile phones or tablets were not the intervention delivery medium were not considered eligible for inclusion.
The initial database search yielded a total of 335 records (see Figure 1). Following the removal of duplicates, 224 records remained. Of these, 20 full-text articles were assessed for eligibility. A total of six studies were excluded for the following reasons: three were pilot studies (Drapalik et al., 2022; Lee et al., 2023; Safi et al., 2022); one did not involve the use of a portable device (Alkinj et al., 2022); one included participants with both ASD and ADHD (J. K. Y. Chan et al., 2024); and one did not implement an intervention targeting social skills (Tuba Ceyhun & Kara Savaş, 2025). Consequently, 14 studies were included in the final synthesis.
Figure 1. PRISMA flowchart. **: No automation tools were used; all records were excluded by humans (see the tables in Appendix A).
The search results obtained from the four databases were screened to determine study eligibility according to the established inclusion and exclusion criteria. Title and abstract screening were followed by full-text assessment of potentially eligible studies. The initial screening and selection of studies were conducted by the first author, and the eligibility decisions were subsequently reviewed by the other authors. Any uncertainties or disagreements regarding study eligibility were discussed among the authors and resolved through consensus.
To minimize potential bias and ensure consistency throughout the review process, the established inclusion and exclusion criteria were applied systematically during study selection. Data extraction and coding were conducted by the first author using the predefined data extraction framework and were subsequently reviewed by the other authors. The extracted information and coding decisions were discussed among the authors to ensure consistency and agreement across the included studies.
Agreement was reached at the title and abstract screening, full-text assessment, and data extraction and coding stages, and no unresolved discrepancies remained. Because agreement was established through review and consensus rather than through parallel independent duplicate assessment, no formal inter-rater reliability coefficient was calculated.

2.3. Data Extraction and Coding Measures

To facilitate interpretation and organization, the fourteen studies included in this review were systematically examined, classified, coded, and evaluated manually according to a set of predefined criteria: (a) year of publication; (b) participants’ age range (in years); (c) sample characteristics (including sample size and gender); (d) duration of the intervention; (e) measurement system; (f) the mobile applications and portable devices employed in each intervention; (g) intervention outcomes; (h) reported limitations, along with recommendations for future research; (i) financial support.
When study-level information was not reported or unclear, it was recorded as “not reported”, and no imputation was performed. Descriptive summaries for variables with missing information, such as participant sex, were calculated using only the available reported data. No statistical data conversions were performed.
Because the included studies employed heterogeneous research designs and outcome metrics, no common effect measure was imposed across studies. Where primary studies reported numerical effect-size estimates for outcomes included in the synthesis, these estimates were extracted and retained in the metric reported by the original authors. No effect-size conversions or post hoc effect-size calculations were performed when such estimates were not reported. Moreover, no formal assessment of risk of bias due to missing results, including publication bias or selective reporting, was conducted.
Following data extraction, the specific social skill outcomes reported across the included studies were grouped inductively into three broader outcome categories: (1) communication and pragmatic language skills, (2) social–emotional and interpersonal skills, and (3) cognitive and pre-academic skills. This categorization was developed after examination of the extracted outcomes to facilitate the organization and narrative synthesis of the findings and was not used to determine study eligibility or selection.

2.4. Systematic Visual Analysis of SCED Studies

Intervention effects reported in ten of the fourteen studies included in the review, namely the ten studies employing single-case experimental designs (Alzyoudi & Alghazali, 2025; Chapin et al., 2022; Costescu et al., 2025; Garcia et al., 2023; Genc-Tosun et al., 2023; Güler & Erdem, 2022; Khoirunnisa et al., 2025; Osos et al., 2021; Sng et al., 2022; Waddington et al., 2023) were examined using systematic visual analysis, following the guidelines provided by Kratochwill et al. (2010) in the What Works Clearinghouse Single-Case Design Technical Documentation. The graphical data presented in the original studies were evaluated with respect to level, trend, variability, immediacy of effect, overlap between baseline and intervention phases, and consistency of data patterns across comparable phases, participants, and target behaviors, where applicable. These characteristics were considered collectively to determine whether the graphical data provided evidence of an intervention effect.
No sensitivity analyses were conducted to assess the robustness of the synthesized results.

3. Results

3.1. Participant’s Characteristics

Across the 14 studies included in this review, the total sample comprised 201 children, including 154 children with ASD and 47 typically developing children who served as the active control group in Hassan et al. (2025). Participants’ ages ranged from 3 to 12 years. Sex was not reported in three studies (Anam et al., 2025; Hassan et al., 2025; Khoirunnisa et al., 2025). Therefore, sex-specific descriptive summaries were based only on studies that reported this information. Among the studies reporting sex, data were available for 78 participants, of whom 61 were boys and 17 were girls.

3.2. Duration of the Intervention

The duration of interventions varied considerably across the included studies. In four studies, intervention length was not predetermined but was contingent on participants reaching a predefined mastery or performance criterion (Genc-Tosun et al., 2023; Güler & Erdem, 2022; Osos et al., 2021; Waddington et al., 2023). Five studies reported a defined intervention or use period ranging from one week to two months (Alzyoudi & Alghazali, 2025; Anam et al., 2025; Hassan et al., 2025; Hesami et al., 2025; Khoirunnisa et al., 2025). The remaining five studies described intervention exposure primarily in terms of the number or frequency of sessions rather than a fixed multi-week intervention period (Chapin et al., 2022; Costescu et al., 2025; Garcia et al., 2023; Lyu et al., 2024; Sng et al., 2022). Reported individual session durations varied across studies, although session duration was not consistently reported for all interventions.

3.3. Research Design

The studies included in this review (Table 1) exhibited substantial variability in research design. The majority employed single-case experimental designs. Specifically, three studies used a multiple probe design (Chapin et al., 2022; Osos et al., 2021; Sng et al., 2022), whereas four studies implemented a multiple baseline design (Alzyoudi & Alghazali, 2025; Genc-Tosun et al., 2023; Khoirunnisa et al., 2025; Waddington et al., 2023). Two studies adopted an alternating treatment design (Costescu et al., 2025; Güler & Erdem, 2022), and one study utilized functional analysis (Garcia et al., 2023).
Table 1. This table presents the year of publication, age range, sample, duration of intervention, methodology, measurement system, applications used in the interventions, outcomes, limitations and financial support.
Regarding group-based research designs, three studies employed group experimental designs. One study implemented a randomized controlled trial (RCT) (Hassan et al., 2025), another used a between-subjects controlled design (Lyu et al., 2024), and one adopted a quasi-experimental design (Anam et al., 2025). Finally, Hesami et al. (2025) employed an empirical pre-test–post-test design with a two-month follow-up. The authors reported that participants were randomly divided into experimental and control groups.

3.4. Financial Support

Regarding the funding of the included studies, six studies reported their funding sources (Anam et al., 2025; Chapin et al., 2022; Costescu et al., 2025; Khoirunnisa et al., 2025; Lyu et al., 2024; Waddington et al., 2023), four stated that they received no financial support (Alzyoudi & Alghazali, 2025; Genc-Tosun et al., 2023; Güler & Erdem, 2022; Hesami et al., 2025), and four did not report whether they received funding or identify any funding source (Garcia et al., 2023; Hassan et al., 2025; Osos et al., 2021; Sng et al., 2022).

3.5. Quality Appraisal

Methodological quality was assessed using the Mixed Methods Appraisal Tool (MMAT) version 2018, a validated framework developed by the team led by Pierre Pluye at McGill University. The MMAT was selected due to its capacity to critically appraise a wide range of study designs within a single integrated framework.
Twelve of the included studies (Alzyoudi & Alghazali, 2025; Anam et al., 2025; Chapin et al., 2022; Costescu et al., 2025; Garcia et al., 2023; Genc-Tosun et al., 2023; Güler & Erdem, 2022; Khoirunnisa et al., 2025; Lyu et al., 2024; Osos et al., 2021; Sng et al., 2022; Waddington et al., 2023) employed a quantitative non-randomized design. All twelve studies reported clearly defined research questions, and their data collection procedures were aligned with the stated study objectives.
Regarding sample representativeness, one study (Anam et al., 2025) was rated as unclear, as the sample consisted exclusively of children with mild learning needs, which may limit generalizability to the broader target population. With respect to measurement appropriateness, three studies (Alzyoudi & Alghazali, 2025; Garcia et al., 2023; Sng et al., 2022) were rated as unclear, as data collection was conducted exclusively within school-specific contexts, thereby potentially limiting external validity.
In addition, two studies raised concerns regarding measurement procedures. Khoirunnisa et al. (2025) relied primarily on researcher-based observations, while Anam et al. (2025) used parent and teacher reports as primary data sources. Furthermore, two studies were considered to have methodological limitations in implementation. Chapin et al. (2022) included an insufficient number of intervention sessions, whereas Güler and Erdem (2022) reported that several sessions were delivered solely by the researcher, which may have introduced potential bias.
With regard to outcome data completeness, three studies were rated as uncertain. Both Anam et al. (2025) and Khoirunnisa et al. (2025) lacked a control group and implemented relatively short intervention periods, while Chapin et al. (2022) reported incomplete data due to inconsistent participant attendance. Regarding control of confounding variables, Garcia et al. (2023) employed a multi-component intervention design, which limited the ability to isolate the specific contribution of individual components to observed behavioral changes. Finally, intervention fidelity was adequately maintained across all included studies.
The remaining two studies (Hassan et al., 2025; Hesami et al., 2025) employed quantitative randomized designs. Both studies presented clearly defined research questions, and their data collection procedures were aligned with their stated objectives. Hesami et al. (2025) reported that participants were randomly divided into experimental and control groups. However, the specific randomization procedure was not described. However, in terms of baseline comparability, Hesami et al. (2025) reported variation in autism severity across groups, which may have affected initial group equivalence. Regarding outcome data completeness, Hesami et al. (2025) included a relatively short follow-up period, limiting the generalizability of findings over time. Moreover, outcome assessors were not blinded in either study. Hassan et al. (2025) relied on parent and teacher reports, whereas Hesami et al. (2025) collected data through family feedback. Finally, intervention adherence was high across both studies, with participants following assigned protocols as intended.
For reasons of methodological rigor, all studies employing single-case experimental designs were additionally assessed using the Single-Case Experimental Design (SCED) Scale (Tate et al., 2008), as general critical appraisal tools (e.g., MMAT) are not sufficient for evaluating internal validity and experimental control in single-case experimental designs.
To evaluate the methodological quality of the included studies, the 11-item SCED Scale, developed by Tate et al. (Tate et al., 2008), was utilized. This tool is recognized as a reliable and valid instrument for assessing the rigor of single-case experimental designs and fostering higher standards in research reporting. The scale consists of one item describing participant characteristics and ten items specifically addressing methodological quality. These items evaluate fundamental components, including the operational definition of target behaviors, the appropriateness of the experimental design, the quality of baseline data, and the graphical presentation of raw data. Furthermore, the scale assesses critical criteria such as inter-observer reliability, evaluator independence, and the application of statistical analyses to mitigate bias. The SCED Scale comprises 11 items; however, Item 1 (Clinical history) is reported descriptively and does not contribute to the methodological quality score. Accordingly, the total methodological quality score ranges from 0 to 10 and is calculated based on Items 2–11. Item 10 (Replication) of the SCED Scale refers to replication of treatment application and outcomes across participants, therapists, or settings and should not be interpreted as equivalent to the more stringent requirements for repeated demonstrations of experimental effect used by Kratochwill et al. (Kratochwill et al., 2010) to establish a functional relation. The results are presented in Table 2.
Table 2. Review of Articles Included According to the SCED Scale.

3.6. Systematic Visual Analysis of Intervention Effects and Cross-Study Synthesis

Following the methodological quality appraisal using the SCED Scale (Tate et al., 2008), we conducted a systematic visual analysis of the graphical data reported in the ten studies employing single-case experimental designs (SCEDs), followed by a cross-study synthesis of intervention effects. Specifically, Osos et al. (2021) showed low and stable baseline responding, followed by clear increases in the targeted social skill after intervention introduction across all four participants. Effects were immediate and showed limited overlap for Earl and Alex, whereas Milly and Oscar demonstrated more gradual and variable improvement. Collectively, the findings support a replicated intervention effect, although the relative advantage of the video-enhanced over the electronic schedule varied across participants.
Similarly, Chapin et al. (2022) demonstrated low and stable baseline responding, followed by immediate increases in communicative turns after the staggered introduction of the intervention across all three participants, with no overlap between baseline and intervention data. Although intervention responding was variable, particularly for Bella and Noah, the change in level was consistently replicated across participants while those remaining in baseline continued to show minimal responding. Nevertheless, the graphical data support a functional relation, although the 27-day gap before Noah’s intervention reduces confidence in the final replication.
In contrast, the findings exhibited by Sng et al. (2022) were less consistent. Visual analysis showed low and relatively stable baseline responding, with no clear improvement following the original iPad intervention across the three participants. Kurt improved only after changes to the probe procedure and additional prompting, Albert improved following explicit teaching with laminated cards, and Leo showed no intervention effect. Taken together, the effects were inconsistent across participants and cannot be attributed specifically to the iPad app, providing no convincing evidence of a functional relation for the original intervention.
Alzyoudi and Alghazali (2025) displayed stable baseline performance followed by an immediate increase and a consistent upward trend during intervention for both participants, with little overlap between phases. However, the intervention appears to have been introduced simultaneously for only two participants, rather than being staggered across at least three tiers. Therefore, the graphs suggest improvement following the iPad-based intervention; however, the available graphical evidence does not satisfy accepted standards for demonstrating a functional relation according to the Kratochwill et al. criteria.
Moreover, Genc-Tosun et al. (2023) showed low and stable baseline responding, followed by clear increases after the staggered introduction of the intervention across three question categories for both participants. Although some effects were delayed and initially overlapped with baseline, particularly for Cem, responding eventually reached high and relatively stable levels, with the effect replicated across behaviors. Collectively, the graphical data support a functional relation, although variability and procedural modifications were observed for some target behaviors.
Waddington et al. (2023) also demonstrated low baseline responding followed by immediate increases in correct requests during intervention for both participants, with little overlap between phases. Grace’s responding was initially variable before stabilizing at high levels, whereas Jeremy showed a gradual upward trend after an initial increase, with both participants maintaining high performance during the choice phase. Although the multiple-baseline design included only two participants, the findings indicate positive intervention effects; however, the graphical data provide insufficient evidence to demonstrate a functional relation according to the Kratochwill et al. (2010) criteria.
Khoirunnisa et al. (2025) exhibited increasing baseline trends followed by further gradual improvements during the AR-based intervention, with little overlap between phases across participants and outcomes. However, the intervention was not clearly staggered across participants, and performance remained high or continued to increase during the second baseline phase. Therefore, the findings indicate positive changes in answering and commenting skills, although the available graphical evidence remains insufficient to demonstrate a functional relation according to the Kratochwill et al. criteria.
Güler and Erdem (2022) used an alternating-treatments design to compare animated and non-animated mobile social story maps. For social communication outcomes, baseline responding was low and stable for all three participants, followed by clear increases after intervention introduction. Arda reached criterion after three animated and four non-animated sessions, Hanife after six and eight sessions, respectively, and Zübeyde after two sessions in both conditions. High responding was generally maintained during follow-up, and generalization was demonstrated for Arda and Zübeyde and partially for Hanife. Nevertheless, the two treatment conditions converged at high-performance levels, and the graphical data did not demonstrate a consistent differential effect favoring animated over non-animated delivery. Thus, the study provides clear evidence of improvement relative to baseline but limited evidence that one presentation format was superior to the other.
Costescu et al. (2025) also employed an alternating-treatments design, comparing printed and mobile Social Stories. Baseline performance was stable with low intra-individual variability, and all three participants showed immediate increases in social-norm comprehension after intervention introduction, with little or no overlap between baseline and intervention scores. However, the mobile and printed conditions overlapped substantially and produced similar levels and trends. The authors’ Wilcoxon analyses showed significant differences between baseline and each intervention condition for all participants, but no significant differences between mobile and printed delivery. Therefore, the visual and statistical evidence supports improvement following Social Stories but does not support a differential advantage of mobile delivery.
Garcia et al. (2023) conducted a multielement functional analysis followed by a reversal-design treatment evaluation of function-based differential reinforcement combined with visual feedback from a smartphone app. For Sam, loud voice-volume responses decreased substantially when the modified DR of A-VVR + Q-VVR intervention was introduced, increased during the return to baseline, and decreased again when treatment was reintroduced, supporting a replicated treatment effect. For Damien, loud responses initially decreased during treatment and increased when baseline was reinstated; however, the decrease was not reproduced to the same extent after treatment reintroduction, and responding remained variable even after an enhanced intervention was introduced. Accordingly, the treatment evidence was clear for Sam but mixed/inconclusive for Damien. Moreover, because the smartphone app formed part of a multicomponent function-based intervention, the observed changes cannot be attributed specifically to the app.
Beyond the visual evidence of intervention effectiveness, several studies demonstrated limitations regarding data analysis and generalization. Osos et al. (2021), Sng et al. (2022), Alzyoudi and Alghazali (2025), Güler and Erdem (2022), and Garcia et al. (2023) did not report formal inferential statistics or single-case effect-size estimates, whereas Costescu et al. (2025) supplemented the visual analysis with Wilcoxon tests. Furthermore, limitations regarding generalization were evident across several studies. Osos et al. (2021) and Alzyoudi and Alghazali (2025) did not systematically program, measure, or report the generalization of communication skills across novel settings, untrained individuals, or naturalistic environments. Similarly, Costescu et al. (2025) did not directly assess the application of learned social norms in naturalistic interactions, while Garcia et al. (2023) did not provide evidence of generalization or maintenance across settings and time. In contrast, Güler and Erdem (2022) explicitly assessed generalization, with evidence of transfer reported for two participants and partial generalization for a third.
Methodological constraints concerning observer bias and assessor independence were also evident across several studies. In research conducted by Khoirunnisa et al. (2025), Waddington et al. (2023) and Alzyoudi and Alghazali (2025), the data assessors were internal to the research and intervention teams without explicit blinding to the study conditions. Güler and Erdem (2022) reported high inter-observer and application reliability but did not report assessor blinding or independence for the primary outcome assessment, while Costescu et al. (2025) reported inter-rater reliability without explicit blinding of study personnel. Garcia et al. (2023), in contrast, employed a second independent observer and reported high interobserver agreement across functional-analysis and treatment sessions. Notably, Khoirunnisa et al. (2025) reported that two researchers compared their observational ratings and resolved discrepancies through discussion and stated that the validity and reliability of the measuring instrument had been tested using SPSS. However, no quantitative inter-rater reliability coefficient or agreement percentage was reported. The study also provided no direct evidence of skill transfer to real-life social interactions. Conversely, Chapin et al. (2022) and Genc-Tosun et al. (2023) demonstrated the strongest methodological rigor among the included SCED studies, satisfying all assessed SCED Scale criteria.
Taken together, across the ten SCED studies, the visual evidence for intervention effectiveness was heterogeneous. Chapin et al. (2022) and Genc-Tosun et al. (2023) provided the strongest evidence of a functional relation, with clear and replicated changes across multiple tiers, while Osos et al. (2021) also demonstrated a clear overall intervention effect, although comparative outcomes varied across participants. Güler and Erdem (2022) and Costescu et al. (2025) showed clear improvements relative to baseline, but their alternating-treatments comparisons did not demonstrate a consistent differential advantage of one delivery format over the other. Garcia et al. (2023) demonstrated a replicated treatment effect for one participant, whereas the effect for the second participant was less consistent. In contrast, Alzyoudi and Alghazali (2025), Waddington et al. (2023), and Khoirunnisa et al. (2025) reported positive changes without sufficient evidence of experimental control according to the criteria applied, whereas Sng et al. (2022) showed mixed and participant-specific effects. Therefore, the findings indicate generally positive but heterogeneous evidence across the ten SCED studies, with substantial variation in the strength of experimental control and consistency of effects across designs and participants.

3.7. Effects of the Intervention

Across the 14 studies included in the present review, a broad range of social skill outcomes was assessed among children with ASD. The studies were categorized according to the type of intervention employed, with portable devices serving as a central component of the intervention delivery. Specifically, two utilized social stories, four involved Augmentative and Alternative Communication, three employed Augmented Reality, two used serious games, one targeted on-topic conversational responses, one utilized video-enhanced activity schedules, and one focused on voice volume responses.
Numerical effect-size estimates were extractable for six of the 14 included studies. Among the SCED studies, Chapin et al. (2022) reported Tau-U = 1.00 for all three participants, Genc-Tosun et al. (2023) reported Tau-U values ranging from 0.37 to 1.00 across participants and question categories, and Waddington et al. (2023) reported Tau-U values ranging from 0.98 to 1.00 across participants and intervention phases. Khoirunnisa et al. (2025) reported Cohen’s d values ranging from 1.76 to 2.47 for question-answering and from 1.62 to 2.67 for relevant commenting, while Hesami et al. (2025) reported partial η2 = 0.236 for the post-test group effect and 0.077 at follow-up. Anam et al. (2025) reported one-sample Cohen’s d values for questionnaire ratings relative to the neutral-scale midpoint; these values reflected deviations in questionnaire ratings rather than pre–post intervention effect sizes. The remaining eight studies did not provide numerical effect-size estimates for the synthesized outcomes that could be extracted without additional calculation.

3.7.1. Portable Devices and Social Stories

Social Stories represent an evidence-based instructional approach widely used to support children and adolescents with ASD in the acquisition of appropriate social skills. They function as structured narratives that model effective interpersonal behaviors, thereby promoting socially adaptive responses and facilitating social inclusion (Riga et al., 2021). Two included studies examined Social Stories delivered through portable devices.
The study by Güler and Erdem (2022) compared animated and non-animated mobile Social Story Maps for listening comprehension and two targeted social communication behaviors, greeting and asking for help. Participants had basic expressive language skills and were able to follow verbal instructions. All three had been diagnosed with atypical autism, two were non-readers, while the third was beginning to acquire reading and writing skills. All three participants reached the response criterion for the targeted social communication behaviors under both conditions. Arda reached criterion after three animated and four non-animated sessions, Hanife after six and eight sessions, respectively, and Zübeyde after two sessions in each condition. Follow-up and generalization data were also collected for the targeted social communication behaviors. The intervention was delivered through the “Mobile Social Story Map”, a tablet application developed and implemented for individuals with ASD at a special education and rehabilitation center in a city in Northwestern Turkey. Sessions were conducted in the classroom whenever the participant’s teacher was available. In cases where the teacher had conflicting lecture schedules and could not attend, the researcher conducted the sessions independently in the meeting room.
Similarly, Costescu et al. (2025) compared the effects of traditional (print-based) and digital Social Stories in teaching social norms to children with ASD. Participants had IQ scores ranging from 73 to 85 and mean utterance lengths of approximately three to six words. All participants exhibited difficulties with social interaction and friendship formation. In this study, Social Stories were delivered via a mobile phone using an image-based application. All evaluation and intervention sessions were implemented by trained psychologists in a therapeutic setting. The study reported improvements in participants’ understanding of social norms under both delivery formats, with no statistically significant difference between digital and print-based conditions.

3.7.2. Portable Devices and Augmentative and Alternative Communication

The primary aim of Augmentative and Alternative Communication (AAC) systems is to support children with ASD by addressing both verbal and non-verbal communication challenges that may arise (Lorah et al., 2015). Advances in technology have facilitated the development of tools such as portable devices, which enable the use of symbols, images, and text to support interactive communication tailored to the needs of children with ASD (Alzrayer & Banda, 2017). The integration of AAC systems with portable technologies provides enhanced mobility and usability, while such devices are generally considered socially acceptable and widely available in everyday contexts (Still et al., 2014). Four included studies examined AAC interventions delivered through portable devices.
The study by Alzyoudi and Alghazali (2025) reported increases in participants’ initiation of requests and verbal interactions following an AAC intervention delivered through an iPad-based speech-generating application. Neither participant had functional speech; one also had an intellectual disability and speech impairments, with severe limitations in both expressive and receptive language. The authors suggested the integration of such technologies into special education settings to address complex communication needs. Notably, this intervention was implemented using an iPad-based speech-generating device (SGD) commercial application for the first time with participants from non-Western contexts. Data was collected in the participants’ natural classroom environment, in collaboration with their teacher, to maintain their regular routines.
In a study by Chapin et al. (2022), the Visual Scene Display (VSD) approach was used in conjunction with AAC systems. In this intervention, photographs of meaningful events were displayed on a tablet, with specific regions (hotspots) programmed to activate speech output when touched. The study was conducted using the “EasyVSD” commercial application on a Samsung Pro tablet with three toddlers. All three participants had complex communication needs and used minimal speech that was insufficient to meet their everyday communication needs. The study reported increases in communicative turn-taking and communication engagement during the intervention. The intervention was conducted by the first researcher, a certified special education teacher. The study took place at an early childhood education program that served both children with and without disabilities.
Speech-generating devices (SGDs) constitute a subcategory of AAC systems. These electronic tools incorporate a large set of symbols, including photographs and color or black-and-white line drawings representing words or phrases, and can produce auditory output through digitized or synthesized speech (Schlosser & Koul, 2015). Two included studies examined SGDs delivered through portable devices.
Waddington et al. (2023) conducted a study using the “Proloquo2Go” commercial application on an iPad and examined instructional procedures for teaching children with ASD to use SGDs to request participation in social routines. Specifically, the study evaluated an intervention designed to teach two children—who had already acquired requesting skills for tangible items—to request continuation of social interactions using an SGD. Both participants exhibited substantial receptive and expressive communication delays, with VABS-II age-equivalent scores ranging from 0 to 14 months in receptive communication and 9 months for expressive communication. The social routines included, for example, peek-a-boo, making funny faces, foot massages, singing “Five Little Monkeys Jumping on the Bed,” piggyback rides, tickling, singing “Row, Row, Row Your Boat,” and bouncing on a ball. The study reported increases in participants’ requests for continuation of social routines with their parents and in their selection between different routines. All sessions took place in a university-based clinic. The intervention was primarily delivered by children’s mothers, with implementation support provided by the first three authors throughout the study.
The study by Genc-Tosun et al. (2023) investigated the effects of simultaneous SGD use with dynamic screen displays on the acquisition of multistep question-answering skills. The intervention employed the “Dokun Konus” a commercial iPad-based speech-generating application with two children with ASD. Both participants had very limited functional speech and social skills. One did not use words to communicate whereas the other used approximately five words consistently. Their while cognitive levels could not be determined because neither participant completed the Stanford–Binet assessment. The study reported increases in participants’ correct responses to multistep questions, with maintenance data collected at a five-week follow-up. Teachers also reported perceiving the intervention as effective and feasible despite having no previous experience with SGDs. The intervention with the first child was implemented by a special education teacher, while the intervention with the second child was carried out by a special education doctoral student (third author). For the first child, all sessions were held in his bedroom at home. For the second child, all sessions were conducted in a classroom in the developmental support unit of a university. Three included studies examined AR-based interventions delivered through portable devices.

3.7.3. Portable Devices and Augmented Reality

Augmented Reality (AR) refers to a technology that integrates virtual elements into the real-world environment in real time. Specifically, it overlays digitally generated features onto physical contexts through three-dimensional visualization techniques (Doulah et al., 2023; El Shemy et al., 2024; Marto et al., 2019). AR integrates virtual elements into real-world environments and has been applied in interventions involving children with ASD (King et al., 2014).
The study by Khoirunnisa et al. (2025) investigated an AR-based intervention targeting social communication skills in children with ASD. The sample consisted of four children aged 7 to 12 years with limited or absent expressive language abilities. Communication profiles varied across participants, with difficulties including minimal or limited verbal communication, initiating social interactions, and maintaining eye contact. The findings indicated improvements in communication skills, particularly in participants’ ability to respond appropriately and engage in dialogue. More specifically, following the intervention, children demonstrated increased capacity to answer questions and provide contextually relevant comments within an AR-mediated interactive environment. The intervention was delivered via a custom mobile application. The research was conducted in NASOM, Melaka, Malaysia, in a room adapted for the intervention session by the researchers.
Similarly, the study by Anam et al. (2025) aimed to support children with ASD and mild learning difficulties in learning the English alphabet, while also examining whether the intervention influenced social engagement and communication skills. The study reported improvements following the use of the “FatimAR”, a smartphone application developed using the open-source MindAR framework and the React Native programming language, in combination with the “We Live by Knowledge Book”, in both letter recognition and recall of the English alphabet. In addition, parents and teachers reported increased social engagement and communication attempts among the participating children. The intervention sessions were conducted within the participants’ homes.
Finally, the study by Lyu et al. (2024) introduced “EMooly,” a tablet-based game designed to engage caregivers of children with ASD through the integration of Augmented Reality (AR) and Artificial Intelligence (AI). The intervention aimed to enhance both social skills and empathy in children with ASD. The system was developed collaboratively by five experts in neuroscience and education and incorporated individualized social stories targeting emotion recognition and facial expression interpretation. The intervention was conducted across two special education centers. In addition to the research team, the children’s caregivers and, in some cases, their parents were actively involved in the process. Results from the sample of 24 children indicated improvements in emotion recognition skills following the intervention. All participants had sufficient cognitive abilities to engage in basic verbal communication with their caregivers and to understand basic emotions.

3.7.4. Portable Devices and Serious Games

Serious games constitute a category of educational interventions that differ from entertainment-oriented games due to their explicit design focus on skill acquisition and development. Their primary aim extends beyond recreation, targeting learning outcomes and cognitive enhancement in users (Carneiro et al., 2024). In the context of rapidly evolving digital technologies, serious games offer a range of advantages, including the ability to simulate ecologically valid, real-life scenarios (Simões et al., 2018). Accordingly, they represent a valuable adjunct to conventional therapeutic and educational interventions for individuals with ASD. Two included studies examined serious games delivered through portable devices.
The study by Hesami et al. (2025) focused on the development of a custom mobile serious game titled “Kookism” and evaluated its effectiveness in teaching Persian vocabulary to children with ASD. Participants had verbal comprehension ages ranging from 16 to 30 months, children with severe intellectual impairments or psychological disorders were excluded, although autism severity varied across participants and some exhibited echolalia. Participants were randomly divided into two groups, one receiving Applied Behavior Analysis (ABA) alone, and the other receiving ABA in combination with the ‘Kookism’ game. The children played the game at home while being monitored by their families, and data regarding verbal perception was collected with the assistance of the parents. The results indicated a statistically significant difference between the experimental and control groups in favor of the intervention group with regard to gains in receptive vocabulary. Specifically, participants receiving ABA in combination with the “Kookism” game showed greater gains in receptive vocabulary than participants receiving ABA alone.
Similarly, Hassan et al. (2025) developed a serious multiplayer mobile game, “Zirkus,” for Android devices, aimed at enhancing socio-emotional functioning in children with ASD. Participants demonstrated average-range verbal and nonverbal cognitive abilities and represented heterogeneous range of ASD profiles, including childhood autism, Asperger syndrome, atypical autism, and PDD-NOS. The game incorporates interactive learning modules designed to facilitate emotion understanding and recognition. The primary objective of the study was to improve emotional recognition, empathy, and prosocial behavior. The intervention relied on a collaborative framework involving caregivers and researchers in three different autism centers. Findings indicated that participants demonstrated improved abilities in identifying and differentiating emotional states.

3.7.5. Portable Devices and Additional Intervention Models

Three additional studies were included in this review, as they did not meet the previously defined thematic criteria.
The first study by Sng et al. (2022) examined whether the commercial iPad application “Conversation Coach” by Silver Lining Multimedia could support children with ASD in selecting appropriate, on-topic responses during conversational exchanges, and whether these skills could generalize to naturalistic environments. The intervention employed scripted prompts with three response options: one correct (on-topic and socially appropriate), one partially appropriate, and one off-topic. Moreover, the intervention was carried out at the school by one of the researchers who is a trained special educator. The findings indicated that instruction delivered exclusively via iPad was insufficient for participants to master the targeted conversational skill. Participants had IQ scores ranging from 51 to 75 and all fell within the severe symptom range for ASD on the CARS-2; PPVT age-equivalent scores ranged from 3.1 to 3.8 years.
The second study by Osos et al. (2021) investigated the effectiveness of video-enhanced activity schedules delivered via the Apple Keynote iPad commercial application in improving social skills in children with ASD. All participants used at least two-word phrases, with MSEL age-equivalent scores ranging from 24 to 40 months for expressive language and from 17 to 46 months for receptive language. All sessions took place within the EIBI therapy room during regular therapy hours. The room was physically arranged in a manner like a preschool classroom. The intervention was implemented by the first author, while trained research assistants who regularly worked with the children were present during sessions to collect data. The intervention was compared with electronic activity schedules consisting solely of static images and text. Results indicated variability in learning outcomes as two out of four participants acquired the targeted skills more rapidly using video-enhanced schedules, one participant demonstrated equivalent performance across both conditions, and one participant met learning criteria only under the static image condition. Although video preparation required additional time, differences in participants’ performance were observed across the two instructional conditions.
Children with ASD often experience difficulties in speech prosody, particularly in relation to vocal intensity, rhythm, rate, and intonation patterns. Lastly, Garcia et al. (2023) implemented an intervention targeting excessively loud speech in children with ASD. The participants were two boys who exhibited elevated vocal intensity and vocal stereotypies. Both participants could produce one- to three-word utterances and had basic functional verbal communication skills. The intervention utilized the “Voice Meter Pro” commercial application on an iPad, which provided real-time visual feedback for vocal intensity (blue indicating quiet speech, green appropriate intensity, and red loud speech). All sessions were conducted in the participants’ homes. Results showed that for one participant, the intervention reduced high-intensity vocalizations and increased appropriately modulated speech. For the second participant, outcomes were inconclusive.
Across the included studies, outcomes were categorized into three broad domains: (1) communication and pragmatic language skills, (2) social–emotional and interpersonal skills, and (3) cognitive and pre-academic skills. Findings across these domains were mixed. While several studies reported improvements in targeted behaviors, the available evidence was insufficient to determine whether these improvements represented broader changes in social competence or generalized social functioning.

3.8. Social Validity

Only four out of the fourteen reviewed studies (28.5%) reported data regarding social validity, while the remaining studies did not address this aspect. In all studies that reported social validity data, stakeholders evaluated the interventions and their outcomes positively. Specifically, Güler and Erdem (2022) collected social validity data from the participants’ parents and teachers at the special education center to capture the perspectives of those familiar with the research process. In their study, Costescu et al. (2025) ensured social validity by tailoring the social stories used in the intervention to meet each child’s individual needs. Furthermore, Chapin et al. (2022) assessed social validity by having four early childhood special education professionals, two teachers, an occupational therapist, and a paraeducator, view one-minute video clips of the participants during both baseline and intervention sessions. All four professionals strongly agreed that the intervention was enjoyable for the children and contributed to improving their communication skills. Finally, Genc-Tosun et al. (2023) collected social validity data indicating that even teachers without prior experience using SGDs perceived them as effective and feasible tools for teaching communication skills.

3.9. Generalization and Maintenance Across Studies

Across the 14 included studies, generalization was explicitly measured in five studies: Genc-Tosun et al. (2023); Waddington et al. (2023); Chapin et al. (2022); Sng et al. (2022); and Güler and Erdem (2022). In Lyu et al. (2024) and Hassan et al. (2025), transfer to real-life or untrained contexts was incorporated into the intervention design but was not assessed separately. The remaining seven studies—Costescu et al. (2025), Hesami et al. (2025), Alzyoudi and Alghazali (2025), Osos et al. (2021), Khoirunnisa et al. (2025), Garcia et al. (2023) and Anam et al. (2025)—reported neither programmed nor measured generalisation. Finally, maintenance or follow-up data were collected in only four studies: Hesami et al. (2025); Genc-Tosun et al. (2023); Güler and Erdem (2022); and Hassan et al. (2025). No maintenance data were reported in the remaining ten studies.

4. Discussion

In contemporary contexts, technological development is advancing at a rapid pace in response to evolving human needs. In the present systematic review, portable devices served as the primary delivery medium across a range of intervention modalities, including Social Stories, AR, serious games, AAC, and other related intervention approaches. This widespread adoption is partly attributed to the documented preference of children with ASD for digital technologies Across the included studies, improvements were reported for a range of directly targeted outcomes; however, these findings varied across studies and research designs and should not be interpreted as evidence of overall intervention effectiveness. These findings should be considered within the broader literature on technology-supported interventions for individuals with ASD. (Hussain et al., 2021; Leung et al., 2021; Toma et al., 2024).
An equally significant finding of the present review is the prevalent use of commercial applications in more than half of the included studies (Alzyoudi & Alghazali, 2025; Chapin et al., 2022; Garcia et al., 2023; Genc-Tosun et al., 2023; Hesami et al., 2025; Osos et al., 2021; Sng et al., 2022; Waddington et al., 2023), all of which are easily accessible via major software marketplaces like App Store and Google Play Store. This observation is particularly noteworthy, as it demonstrates that the implementation of these interventions does not require specialized programming skills from the end-user. Consequently, this lowers the barrier to entry, significantly facilitating the adoption of such tools by practitioners in the field including educators, special education teachers, and mental health professionals, thereby rendering this type of intervention more practical and accessible for daily clinical and educational practice.
Regarding study outcomes, improvements were reported in socio-emotional skills (Güler & Erdem, 2022; Hassan et al., 2025; Lyu et al., 2024), communication skills (Alzyoudi & Alghazali, 2025; Güler & Erdem, 2022; Khoirunnisa et al., 2025), as well as in broader domains of social functioning, including social engagement (Anam et al., 2025), social routines (Waddington et al., 2023), and social interaction (Alzyoudi & Alghazali, 2025). In addition, gains were observed in specific components of communicative competence in children with ASD, including receptive vocabulary (Hesami et al., 2025), question-answering (Genc-Tosun et al., 2023), turn-taking (Chapin et al., 2022), prosody (Garcia et al., 2023) and on-topic conversational responding (Sng et al., 2022). Given that several included interventions involved parents or caregivers in delivery of interventions or monitoring, the broader family context should also be considered. Identified getting support, social isolation, disruption of daily routines, anxiety, and emotional outbursts as recurring themes in parental burnout among families of children with ASD (Koçak, 2023).
However, given that this remains a relatively emerging field of research, several methodological limitations can be identified. The most prominent limitation concerns small sample sizes (Alzyoudi & Alghazali, 2025; Chapin et al., 2022; Garcia et al., 2023; Genc-Tosun et al., 2023; Güler & Erdem, 2022; Khoirunnisa et al., 2025; Lyu et al., 2024; Osos et al., 2021; Sng et al., 2022; Waddington et al., 2023), as well as restricted age ranges (Güler & Erdem, 2022), both of which limit the generalizability of findings. From a methodological perspective, several studies lacked long-term follow-up assessments (Chapin et al., 2022; Hesami et al., 2025; Waddington et al., 2023), while others relied heavily on subjective reporting—primarily from parents and teachers—for outcome measurement, which may introduce reporting bias (Genc-Tosun et al., 2023; Hassan et al., 2025; Hesami et al., 2025; Waddington et al., 2023). Finally, certain technical and design limitations were also identified, including variability in ASD severity across participants (Hesami et al., 2025) and limited assessment of social skills within real-world contexts (Alzyoudi & Alghazali, 2025; Garcia et al., 2023). An additional limitation of the present review and the resulting evidence base concerns the exclusion of studies involving children with ASD and co-occurring conditions, including Tourette syndrome, visual impairments, hearing loss, and ADHD. Although this criterion was intended to reduce clinical heterogeneity, it narrowed the representativeness of the synthesized population and limits the ecological validity and generalizability of the findings to the broader and more heterogeneous ASD population encountered in real-world educational and clinical settings. Additionally, the review protocol was not prospectively registered in a public registry, such as PROSPERO, before the review commenced. Consequently, the protocol was not publicly available prior to the start of the review, which may limit the transparency and reproducibility of the review process. The absence of contemporaneously recorded database-specific search dates constitutes an additional limitation, as it reduces the reproducibility of the search process. Although the selected databases provided multidisciplinary coverage, the exclusion of additional clinical and technology-focused databases may have resulted in relevant studies being missed.
Furthermore, study selection and data extraction were not conducted independently by multiple reviewers; therefore, no formal inter-rater agreement statistic was calculated. Although eligibility and data extraction decisions were subsequently reviewed by the co-authors and resolved through consensus, the absence of independent duplicate assessment represents a methodological limitation of the review.
Because of the substantial methodological and clinical heterogeneity across studies, conclusions regarding intervention effectiveness should be interpreted cautiously. Rather than indicating definitive evidence of effectiveness, the present findings identify promising intervention approaches that require replication using larger and methodologically rigorous studies. Related single-subject research also highlights the value of combining systematic instructional comparisons with social validity assessment. For example, Koçak et al. (2023) compared direct instruction with simultaneous prompting to teach concrete concepts to children with ASD, while also evaluating social validity.
Based on the literature evaluated in this review, several recommendations for future research are proposed. Firstly, subsequent studies should prioritize the recruitment of larger participant samples to enhance the external validity and generalizability of outcomes across the wider autism spectrum. Furthermore, given the significant heterogeneity in ASD manifestation, symptom severity, and individualized needs documented across the reviewed papers, future research designs must implement rigorous yet adaptive participant selection criteria to better accommodate these unique population characteristics.
Secondly, the current review mapped literature within a strict five-year window (2020–2025) to focus on contemporary applications. A valuable direction for future secondary research would be to eliminate these chronological boundaries. Expanding the inclusion criteria to encompass a broader chronological range will allow future investigators to amass a more extensive sample of studies, thereby offering deeper insights into these specific intervention modalities.
Finally, ASD encompasses a broad spectrum of clinical manifestations and functional levels, which inherently introduces substantial complexity and variability into empirical research. To maintain a relatively homogenous focus, the present review excluded studies involving participants with comorbid conditions like Tourette syndrome, visual impairments, hearing loss, and ADHD. Consequently, future researchers could expand upon this work by systematically incorporating literature that includes participants with such comorbidities, thereby offering a more representative and ecologically valid overview of these interventions.

5. Conclusions

The studies included in this review employed mobile devices as the primary delivery tool across a range of intervention approaches targeting the improvement of social skills in children with ASD. Across the included studies, improvements were reported in several directly targeted outcomes, suggesting that mobile device-based interventions may help support social skills in children with ASD. However, the available evidence remains heterogeneous and is insufficient to establish their overall effectiveness.
In the context of digital interventions targeting social skills in children with ASD, it is important to distinguish between technology as a delivery medium and technology as an active component of cognition. Many applications are conceptualized as passive tools that simply present social information. However, emerging perspectives on technological cognition (Osiurak et al., 2025) suggest that digital tools can play a more active role by shaping how users process, interpret, and apply social information.
In this regard, the apps reviewed in the present study should not be understood solely as platforms for content delivery, but as interactive systems that scaffold social–cognitive processing. This is particularly relevant for children with ASD, who often experience difficulties in spontaneously integrating social cues. Technology, therefore, may function as a structured cognitive partner that supports the integration of social and technical information, rather than acting as a neutral interface.
It is important to note that, in some of the interventions included in the present review, the use of technology was not limited to direct interaction between the child and the technological tool. More specifically, in several studies, caregivers, parents, or teachers actively supported the implementation of the intervention by providing guidance, monitoring, or assistance during the interaction. In these cases, the use of mobile devices was therefore mediated by another person. From the perspective of transactive technical cognition (Osiurak et al., 2025), such interventions may therefore involve a socially distributed cognitive system in which the child, the supporting person, and the technological tool jointly contribute to the intervention process. Accordingly, when active adult support was part of the intervention, the observed outcomes cannot be attributed exclusively to the digital interface. Consequently, the improvements reported following these interventions do not allow firm conclusions to be drawn regarding the extent to which the acquired skills could be transferred independently of caregiver or teacher support.
More broadly, generalisation was explicitly measured in only five of the 14 included studies, while maintenance or follow-up data were reported in four. Consequently, improvements observed within intervention settings should not be interpreted as evidence of broader generalised social competence or long-term durability, and further research should systematically assess transfer across people, settings, tasks, and untrained behaviours, as well as maintenance over time.
Although methodological quality assessment provides information regarding confidence in the reported findings, higher methodological quality scores should not be interpreted as direct evidence of stronger intervention effects.
This review indicates that mobile technologies are increasingly used as tools within interventions for children with ASD, offering flexibility and accessibility. However, the evidence base is characterized by small and heterogeneous samples, as well as limited follow-up assessments. Publication bias and other forms of reporting bias arising from missing results were not formally assessed and therefore cannot be ruled out. This limitation is particularly relevant given the predominance of single-case experimental designs in the included evidence base, as selective publication or reporting of positive intervention outcomes may have influenced the overall pattern of findings. Therefore, their effectiveness should be interpreted with caution, particularly regarding the transfer of skills beyond the intervention context into real-world social interactions.

Author Contributions

Conceptualization, E.-S.P. and A.G.; methodology, E.-S.P., D.P. and A.G.; investigation, E.-S.P.; data curation, E.-S.P.; resources, E.-S.P. and D.P.; writing—original draft preparation, E.-S.P. and A.G.; writing—review and editing, D.P., C.K. and A.G.; supervision, D.P., C.K. and A.G. All authors have read and agreed to the published version of the manuscript.

Funding

This research received no external funding.

Institutional Review Board Statement

Not applicable.

Data Availability Statement

All data extracted from the included studies and used in the present review are reported within the article. No separate extraction dataset is publicly available.

Conflicts of Interest

The authors declare no conflicts of interest.

Appendix A

PsycINFO
Effectiveness of Using Mobile Technology to Improve Cognitive and Social Skills Among Individuals With Autism Spectrum Disorder: Systematic Literature ReviewNo
Using educational robotics to support motor, cognitive, and social skills in a child with spinal muscular atrophy. A single-case studyNo
Online social interaction skill group for adolescents on the autism spectrum: Preliminary outcomes of the START Connections programNo
MiEmo: A multi-modal platform on emotion recognition for children with autism spectrum conditionNo
Bifidobacterium animalis subsp. lactis Probio-M8 alleviates abnormal behavior and regulates gut microbiota in a mouse model suffering from autismNo
Determinants of physical activity of transitioning adult children with Autism Spectrum DisorderNo
Can Social Communication Skills for Children Diagnosed With Autism Spectrum Disorder Rehearsed Inside the Video Game Environment of Minecraft Generalize to the Real World?Nο
The Development of an Escape Room–Based Serious Game to Trigger Social Interaction and Communication Between High-Functioning Children With Autism and Their Peers: Iterative Design ApproachNo
ChatGPT4.0-Delivered Physical Activity Intervention for Children With Autism Spectrum Disorder: Pre-Post Feasibility StudyNo
Improved socio-emotional skills in students with autism spectrum disorder (ASD) following an intervention supported by an augmented gamified environmentNo
Gamification in Mobile Apps for Children With Disabilities: Scoping ReviewNo
Unlocking inclusive education: A quality assessment of software design in applications for children with autismNo
Effectiveness of Artificial Intelligence–Based Platform in Administering Therapies for Children With Autism Spectrum Disorder: 12-Month Observational StudyNo
Research on the Effect of Dance Therapy on Improving Social Communication Ability of Children with AutismNo
Digital Health Interventions Targeting Psychological Health in Parents of Children With Autism Spectrum Disorder: Protocol for a Scoping ReviewNo
ICT training for educators of Granada for working with people with autismNo
Leveraging deep learning for enhanced diagnosis of autism spectrum disorder using resting-state functional magnetic resonance imaging and clinical dataNo
Portrayal of Autism Spectrum disorder and its treatments in Qatar’s leading newspapers: A content analysis studyNo
A Multi-Classifier-Based Recommender System for Early Autism Spectrum Disorder Detection using Machine LearningNo
A Smart System Facilitating Emotional Regulation in Neurodivergent ChildrenNo
ASD2-TL∗ GTO: Autism spectrum disorders detection via transfer learning with gorilla troops optimizer frameworkNo
Developing Culturally Appropriate Content for a Child-Rearing App to Support Young Children’s Socioemotional and Cognitive Development in Afghanistan: Co-Design StudyNo
The Performance of Emotion Classifiers for Children With Parent-Reported Autism: Quantitative Feasibility StudyNo
Altered engagement of the speech motor network is associated with reduced phonological working memory in autismNo
Identifying children at risk: Empowering teachers using the RedFlag appNo
Direct Support Professionals’ Perspectives on Using Technology to Help Support Adults With Autism Spectrum Disorder: Mixed Methods StudyNo
Educational Software as Assistive Technologies for Children with Autism Spectrum DisorderNo
Heart Rate Variability Biofeedback to Treat Anxiety in Young People With Autism Spectrum Disorder: Findings From a Home-Based Pilot StudyNo
Virtual reality and naturalistic developmental behavioral interventions for children with autism spectrum disorderNo
Smartphone App to Address Loneliness Among College Students: Pilot Randomized Controlled TrialNo
In support of neurodiverse participatory sensemakingNo
Development of an online skills training platform for autistic adults: A participatory approachNo
Development and Evaluation of Intelligent Serious Games for Children With Learning Difficulties: Observational StudyNo
Patterns and impact of technology use in autistic childrenNo
Empowering Autistic Creativity Through Art and TechnologyNo
Training and Profiling a Pediatric Facial Expression Classifier for Children on Mobile Devices: Machine Learning StudyNo
An acceptability and feasibility investigation of a community-based motor program for autistic children with moderate and high support needsNo
The impact of face masks on autistic and non-autistic adults’ face processing abilitiesNo
A systematic review for artificial intelligence-driven assistive technologies to support children with neurodevelopmental disordersNo
No evidence that autistic traits predict programming learning outcomesNo
Building the design ICT inventory (DICTI): A Delphi studyNo
Virtual self care: Using virtual reality to support adolescent mental health and wellbeingNo
Impact of screen and social media use on mental healthNo
A Narrative Review to Identify Promising Approaches for Digital Health Interventions to Support Emotion Regulation for Adolescents With Attention-Deficit/Hyperactivity DisorderNo
Can robots do therapy?: Examining the efficacy of a CBT bot in comparison with other behavioral intervention technologies in alleviating mental health symptomsNo
The Impact of Mobile Technology-Delivered Interventions on Youth Well-being: Systematic Review and 3-Level Meta-analysisNo
Deep phenotyping in 3q29 deletion syndrome: recommendations for clinical careNo
Examining clinicians’ concerns delivering telemental health interventions directly to autistic individuals during COVID-19No
Gaze behavior in face-to-face interaction: A cross-cultural investigation between Japan and The NetherlandsNo
Two ways to measure interpersonal synchrony in dance/movement therapy: Comparing accelerometer data with observational dataNo
Face recognition’s practical relevance: Social bonds, not social butterfliesNo
Gaze analysis: A survey on its applicationsNo
Barriers and facilitators to social-emotional health screening in pediatrics: Results from a qualitative study of practitioner perspectivesNo
Barriers and facilitators: The contrasting roles of media and technology in social–emotional learningNo
User-Friendly Chatbot to Mitigate the Psychological Stress of Older Adults During the COVID-19 Pandemic: Development and Usability StudyNo
Loneliness: Adolescents’ perspectives on what causes it, and ways youth services can prevent itNo
A Digital Cognitive-Physical Intervention for Attention-Deficit/Hyperactivity Disorder: Randomized Controlled TrialNo
Professional competencies for sexuality and relationships education in child and youth social care: A scoping reviewNo
The connecting brain in context: How adolescent plasticity supports learning and developmentNo
Biallelic loss-of-function variants in CACHD1 cause a novel neurodevelopmental syndrome with facial dysmorphism and multisystem congenital abnormalitiesNo
A Multiagent Platform for promoting physical activity and learning through interactive educational games using the depth camera recognition systemNo
Digital methodology for parental self-assessment of child developmentNo
Assessing the Usability and Feasibility of Digital Assistant Tools for Direct Support Professionals: Participatory Design and Pilot-TestingNo
Immersive Virtual Reality eHealth Intervention to Reduce Anxiety and Depression in Pregnant Women: Randomized Controlled TrialNo
Serious games to support emotional regulation strategies in educational intervention programs with children and adolescents. Systematic review and meta-analysisNo
Is learning analytics applicable and applied to education of students with intellectual/developmental disabilities? A systematic literature reviewNo
Alternative and Augmentative Communication Technologies for Supporting Adults With Mild Intellectual Disabilities During Clinical Consultations: Scoping ReviewNo
Do we really need this robot? Technology requirements for vestibular rehabilitation: Input from patients and cliniciansNo
Indigenous Parents’ Perspectives of Factors That Facilitate or Impede Engagement in Internet-Based Parenting Support Programs: Interpretive Description StudyNo
University Students’ Opinions on Using Intelligent Agents to Cope with Stress and Anxiety in Social SituationsNo
On the potential of supporting autonomy in online video interview training platformsNo
Virtual reality and mental health in older adults: a systematic reviewNo
Prevention and Treatment of Social Anxiety Disorder in Adolescents: Protocol for a Randomized Controlled Trial of the Online Guided Self-Help Intervention SOPHIENo
Awareness, Prevention, Detection, and Therapy Applications for Depression and Anxiety in Serious Games for Children and Adolescents: Systematic ReviewNo
A social robot to deliver a psychotherapeutic treatment: Qualitative responses by participants in a randomized controlled trial and future design recommendationsNo
Body, emotions, and sexuality in the metaverse: A randomized control trial exploring the use of second life for an avatar-based intervention to support women with female orgasmic disorderNo
Concordance between subjective and objective measures of infant sleep varies by age and maternal mood: Implications for studies of sleep and cognitive developmentNo
A scoping review of the program components, practice components, and outcomes of behaviour support programs delivered to children and young people in out-of-home careNo
Functional patterns of neural activation during vocal emotion recognition in youth with and without refractory epilepsyNo
Associations between touchscreen exposure and hot and cool inhibitory control in 10-month-old infantsNo
Taking a stand or standing aside? How to conceptualize the emerging phenomenon of university activismNo
Integrating People, Context, and Technology in the Implementation of a Web-Based Intervention in Forensic Mental Health Care: Mixed-Methods StudyNo
Social gaming: A systematic reviewNo
Criminal insanity in Bulgaria and Norway: Analysing the prospect of a common approachNo
Using Video Games to Improve Capabilities in Decision Making and Cognitive Skill: A Literature ReviewNo
Social companionship with artificial intelligence: Recent trends and future avenuesNo
A literature survey of the robotic technologies during the COVID-19 pandemicNo
Metaverse-based social skills training programme for children with autism spectrum disorder to improve social interaction ability: an open-label, single-centre, randomised controlled pilot trialYes
Healthcare Interventions for Children Using Nonimmersive Virtual Reality: A Mixed Methods Systematic ReviewNo
Visual attention patterns during a gaze following task in neurogenetic syndromes associated with unique profiles of autistic traits: Fragile X and Cornelia de Lange syndromesNo
Evaluating the Feasibility of Emotion Expressions in Avatars Created From Real Person Photos: Pilot Web-Based Survey of Virtual Reality SoftwareNo
Facial Image-Based Autism Detection: A Comparative Study of Deep Neural Network ClassifiersNo
Developmental Dopaminergic Signaling Modulates Neural Circuit Formation and Contributes to Autism Spectrum Disorder–Related PhenotypesNo
Feasibility and Acceptability of Delivering Pivotal Response Treatment for Autism Spectrum Disorder via Telehealth: Pilot Pre-Post StudyNo
Q-CHAT-NAO: A robotic approach to autism screening in toddlersNo
Helping Optimize Language Acquisition (HOLA) Online Parent Training Modules for Latinx Parents of Toddlers at Risk for ASD: Protocol for a Pilot Funded by the Organization for Autism ResearchNo
Participatory design of augmented reality games for word learning in autistic children: the parental perspectiveNo
Receptive and expressive language ability differentially support symbolic understanding over time: Picture comprehension in late talking and typically developing childrenNo
A mediation analysis of Autistic-like traits and gaming motivations on problem gaming symptoms: Are the effects of social and escape motives the same?No
Digitally Diagnosing Multiple Developmental Delays Using Crowdsourcing Fused With Machine Learning: Protocol for a Human-in-the-Loop Machine Learning StudyNο
Evaluation of the effectiveness of a serious game titled “Kookism” on the receptive lexicon in 4–9-year-old autistic childrenYes
Effects of fecal microbiota transplantation on behavioral abnormality in attention deficit hyperactivity disorder-like model ratsNo
ICT, Manufacturing and Industrial Automation of Biological ProcessesNo
Olly: A tangible for togethernessNo
Use of digital platforms by autistic children and young people for creative dress-up play (cosplay) to facilitate and support social interactionNo
Rule-based expert system supporting Individual Education-and-Therapeutic Program composition in SYSABANo
Unpacking the relationship between screen use and educational outcomes in childhood: A systematic literature reviewNo
Use of Educational Technology in Inclusive Primary Education: Protocol for a Systematic ReviewNo
Loneliness in emerging adulthood: A qualitative study using cultural probes and in-depth interviewsNo
Bullying of female students with intellectual disability in mainstream schools: Personal experiences from Saudi ArabiaNo
Effectiveness of a Web-Based Virtual Simulation to Train Nursing Students in Suicide Risk Assessment: Randomized Controlled InvestigationNo
The Social and Cognitive Online Training (SCOT) project: A digital randomized controlled trial to promote socio-cognitive well-being in older adultsNo
Game-Based Social-Emotional Learning for Youth: School-Based Qualitative Analysis of Brain AgentsNo
Jordanian parental perception of screen time and its association with psychological distress: A cross-sectional designNo
Is the screen time duration affecting children’s language development?—A scoping reviewNo
Navigating Social Cognitive Impairments in Schizophrenia Spectrum Disorders: Protocol for a Pilot Pre-Post Quasi-Experimental Study for Remote Avatar-Assisted Cognitive Remediation TherapyNo
Lending a helping hand to preterm infants: Randomized controlled trial of the impact of ‘sticky mittens’ on exploratory behavior and later developmentNo
Addiction Symptom Network of Young Internet Users: Network AnalysisNo
Effectiveness of Conversational Agents (Virtual Assistants) in Health Care: Protocol for a Systematic ReviewNo
Virtual reality based multiple life skill training for intellectual disability: A multicenter randomized controlled trialNo
Measuring and interpreting individual differences in fetal, infant, and toddler neurodevelopmentNo
Youth with disabilities in residential care in the community: Perceptions and experiences in the transition periodNo
Comparing gross motor performance, physical fitness between young children with and without sensory integration dysfunctionNo
Boundary Objects as Dialogical Learning Accelerators for Social Change in Design for Health: Systematic ReviewNo
The strategic impacts of Intelligent Automation for knowledge and service work: An interdisciplinary reviewNo
Natural Language Processing for COVID-19 Consulting SystemNo
Adaptive virtual agent: Design and evaluation for real-time human-agent interactionNo
Gut Feelings: Vagal Stimulation Reduces Emotional BiasesNo
Engaging Parents and Health Care Stakeholders to Inform Development of a Behavioral Intervention Technology to Promote Pediatric Behavioral Health: Mixed Methods StudyNo
Added value of a virtual approach to simulation-based learning in a manufacturing learning factoryNo
VEGO: A novel design towards customizable and adjustable head-mounted display for VRNo
Survey of Robotics in Education, Taxonomy, Applications, and Platforms during COVID-19No
Gratitude versus children’s rights: An exploration mothers’ attitudes towards disability and inclusive education in PalestineNo
The relation between oxytocin receptor gene polymorphisms, adult attachment and Instagram sociability: An exploratory analysisNo
Microbial metabolites regulate social novelty via CaMKII neurons in the BNSTNo
Jellyfish Search Optimization with Deep Learning Driven Autism Spectrum Disorder ClassificationNo
The Impact of Mobile Technology-Delivered Interventions on Youth Well-being: Systematic Review and 3-Level Meta-analysisNo
The effects of an educational program based on modeling and social stories on improvements in the social skills of students with autismNo
Effectiveness of Using Mobile Technology to Improve Cognitive and Social Skills Among Individuals With Autism Spectrum Disorder: Systematic Literature ReviewNo
Speech and Language Therapists’ Perspectives of Virtual Reality as a Clinical Tool for Autism: Cross-Sectional SurveyNo
Determinants of physical activity of transitioning adult children with Autism Spectrum DisorderNo
Unlocking inclusive education: A quality assessment of software design in applications for children with autismNo
A pilot randomised controlled trial of a telehealth-delivered brief ‘Sleeping Sound Autism’ intervention for autistic childrenNo
Educational Software as Assistive Technologies for Children with Autism Spectrum DisorderNo
Get SET Early to Identify and Treatment Refer Autism Spectrum Disorder at 1 Year and Discover Factors That Influence Early DiagnosisNo
Direct Support Professionals’ Perspectives on Using Technology to Help Support Adults With Autism Spectrum Disorder: Mixed Methods StudyNo
Long-term Memory Testing in Children With Typical Development and Neurodevelopmental Disorders: Remote Web-based Image Task Feasibility StudyNo
Empowering Autistic Creativity Through Art and TechnologyNo
Gamification in Mobile Apps for Children With Disabilities: Scoping ReviewNo
“It’s about sharing a moment”: Parents’ views and experiences of home reading with their autistic children with moderate-to-severe intellectual disabilitiesNo
Seeing it my way: A perspective taking intervention alleviates psychological distress in caregivers of autistic childrenNo
A Digital Cognitive-Physical Intervention for Attention-Deficit/Hyperactivity Disorder: Randomized Controlled TrialNo
Dimensional associations between executive function processes and symptoms of ADHD, ASD, oppositional defiance and anxiety in young school-referred childrenNo
Evaluating the Effects of Adverse Childhood Experiences (ACEs) on the Socio-emotional, Behavioral, and Adaptive Functioning in Diverse and Marginalized Pediatric Patients Experiencing Chronic PainNo
Using virtual reality to enhance attention for autistic spectrum disorder with eye trackingNo
Unpacking the relationship between screen use and educational outcomes in childhood: A systematic literature reviewNo
Reporting guidelines for music-based interventions checklist: Explanation and elaboration guideNo
Building the design ICT inventory (DICTI): A Delphi studyNo
Neuroadaptive Bayesian optimisation to study individual differences in infants’ engagement with social cuesNo
Effectiveness of mental-health interventions for children and adolescents placed in residential care by the welfare services: A systematic reviewNo
The Impact of Mobile Technology-Delivered Interventions on Youth Well-being: Systematic Review and 3-Level Meta-analysisNo
Associations between touchscreen exposure and hot and cool inhibitory control in 10-month-old infantsNo
The bullies are the leaders of the next generation: Inherited aminergic neurotransmitter system changes in socially dominant zebrafish, Danio rerioNo
Get SET Early to Identify and Treatment Refer Autism Spectrum Disorder at 1 Year and Discover Factors That Influence Early DiagnosisNo
The Performance of Emotion Classifiers for Children With Parent-Reported Autism: Quantitative Feasibility StudyNo
Effectiveness of Using Mobile Technology to Improve Cognitive and Social Skills Among Individuals With Autism Spectrum Disorder: Systematic Literature ReviewNo
Metaverse-based social skills training programme for children with autism spectrum disorder to improve social interaction ability: an open-label, single-centre, randomised controlled pilot trialNo
Training and Profiling a Pediatric Facial Expression Classifier for Children on Mobile Devices: Machine Learning StudyNo
XR technologies to enhance the emotional skills of people with autism spectrum disorder: A systematic reviewNo
Feasibility and Acceptability of Delivering Pivotal Response Treatment for Autism Spectrum Disorder via Telehealth: Pilot Pre-Post StudyNo
Direct Support Professionals’ Perspectives on Using Technology to Help Support Adults With Autism Spectrum Disorder: Mixed Methods StudyNo
Participatory design of augmented reality games for word learning in autistic children: the parental perspectiveNo
Gamification in Mobile Apps for Children With Disabilities: Scoping ReviewNo
Assessing the Usability and Feasibility of Digital Assistant Tools for Direct Support Professionals: Participatory Design and Pilot-TestingNo
Serious games to support emotional regulation strategies in educational intervention programs with children and adolescents. Systematic review and meta-analysisNo
Game-Based Social-Emotional Learning for Youth: School-Based Qualitative Analysis of Brain AgentsNo
Building the design ICT inventory (DICTI): A Delphi studyNo
The Social and Cognitive Online Training (SCOT) project: A digital randomized controlled trial to promote socio-cognitive well-being in older adultsNo
Jordanian parental perception of screen time and its association with psychological distress: A cross-sectional designNo
Gaze analysis: A survey on its applicationsNo
Virtual reality based multiple life skill training for intellectual disability: A multicenter randomized controlled trialNo
The Impact of Mobile Technology-Delivered Interventions on Youth Well-being: Systematic Review and 3-Level Meta-analysisNo
Comparing gross motor performance, physical fitness between young children with and without sensory integration dysfunctionNo
Gut Feelings: Vagal Stimulation Reduces Emotional BiasesNo
Adaptive virtual agent: Design and evaluation for real-time human-agent interactionNo
Added value of a virtual approach to simulation-based learning in a manufacturing learning factoryNo
Associations between touchscreen exposure and hot and cool inhibitory control in 10-month-old infantsNo
Social gaming: A systematic reviewNo
Web of Science
Evaluating user interface of a mobile augmented reality coloring application for children with autism An eye-tracking investigationNo
MOLHEM An innovative android application with an interactive avatar-based chatbot for Arab children with ASDNo
A Multimodal Messaging App (MAAN) for Adults With Autism Spectrum Disorder: Mixed Methods Evaluation StudyNo
FRIDA, a Framework for Software Design, Applied in the Treatment of Children with Autistic DisorderNo
A Preliminary Curriculum to Promote Social Skills via Social Narratives and App Development in Youth With AutismNo
Use of Mobile Social Story Maps in the Development of Cognitive and Social Skills of Children With Autism Spectrum DisorderNo
Early diagnosis of autism using Indian autism grading toolNo
Network analysis of autism traits and problematic mobile phone use and their associations with depression among Chinese college studentsNo
Evaluating user interface of a mobile augmented reality coloring application for children with autism: An eye-tracking investigationNo
Effectiveness of a mobile application game (NDTx-01) in enhancing social communication skills in adolescents with autism spectrum disorder or social communication disorder: A randomized controlled pilot trialNo
Effectiveness of IMPUTE ADT-1 mobile application in children with autism spectrum disorder: An interim analysis of an ongoing randomized controlled trialNo
Insights from user experience and evaluation of a mobile health nutrition intervention for children with autism: A qualitative studyNo
The Digital Divide in Technologies for Autism: Feasibility Considerations for Low- and Middle-Income CountriesNo
Digitally mediated social stories perform on par with traditional means of delivery in teaching social norms to adolescents with ASDYes
A Multimodal Messaging App (MAAN) for Adults With Autism Spectrum Disorder: Mixed Methods Evaluation StudyNo
Evaluation of a spherical video-based virtual reality intervention designed to teach adaptive skills for adults with autism: a preliminary reportNo
RETRACTED: An AI-Enabled Internet of Things Based Autism Care System for Improving Cognitive Ability of Children with Autism Spectrum Disorders (Retracted Article)No
Design and Evaluation of a Mobile Robotic Assistant for Emotional Learning in Individuals with ASD: Expert Evaluation StageNo
ProVIA-Kids—outcomes of an uncontrolled study on smartphone-based behaviour analysis for challenging behaviour in children with intellectual and developmental disabilities or autism spectrum disorderNo
Video-Based Interventions for Teaching Individuals With Disabilities Employment Skills: A Systematic ReviewNo
Quantifying preference for social stimuli in young children using two tasks on a mobile platformNo
An mCARE study on patterns of risk and resilience for children with ASD in BangladeshNo
Video-Based Virtual Reality Technology for Autistic Users: An Emerging Technology ReportNo
A systematic review of the utility of assistive technologies for SEND students in schoolsNo
Social attention in the wild—fixations to the eyes and autistic traits during a naturalistic interaction in a healthy sampleNo
Training work-related social skills in adults with Autism Spectrum Disorder using a tablet-based interventionNo
Assessing Video Enhanced Activity Schedules to Teach Social Skills to Children with Autism Spectrum DisorderYes
Using digital social stories to improve social skills in children with autism: a pilot experimental single-subject studyNo
Meta-Analysis of Tablet-Mediated Interventions to Teach Mathematics for Individuals With Autism Spectrum Disorder and/or Intellectual DisabilityNo
Information and communication technologies-based interventions for children with autism spectrum conditions: a systematic review of randomized control trials from a positive technology perspectiveNo
The Use of Digital Interventions for Children and Adolescents with Autism Spectrum Disorder-A Meta-AnalysisNo
A systematic review of the utility of assistive technologies for SEND students in schoolsNo
Using digital social stories to improve social skills in children with autism: a pilot experimental single-subject studyNo
Use of Mobile Social Story Maps in the Development of Cognitive and Social Skills of Children With Autism Spectrum DisorderNo
Meta-Analysis of Tablet-Mediated Interventions to Teach Mathematics for Individuals With Autism Spectrum Disorder and/or Intellectual DisabilityNo
ERIC
Using Apps to Develop Social Skills in Children With Autism Spectrum DisorderNo
Scopus
Feasibility study of emotion mimicry analysis in human–machine interactionNo
Enhancing Learning and Social Skills in Children with ASD-MLN: An Exploratory Study with Augmented Reality InterventionYes
AR as an Educational Technology for the Development of Reading Skills in Children With ASD in Korean Language EducationNo
Effectiveness of a mobile application game (NDTx-01) in enhancing social communication skills in adolescents with autism spectrum disorder or social communication disorder: A randomized controlled pilot trialNo
A New AI Framework to Support Social-Emotional Skills and Emotion Awareness in Children with Autism Spectrum DisorderNo
Mechanical Design and Motion Analysis of a Hybrid Robot for Equine Rehabilitation|乘马康复混联机器人机构设计与运动分析No
Digitally mediated social stories perform on par with traditional means of delivery in teaching social norms to adolescents with ASDNo
Autism Digital Phenotyping in Preschool- and School-Age ChildrenNo
Digital communication and social cognition in adults with frontal lobe epilepsy: A scoping reviewNo
The potential of evaluating shape drawing using machine learning for predicting high autistic traitsNo
Motor Control Adherence to the Two-thirds Power Law Differs in Autistic DevelopmentNo
Evaluating Free Serious Game-Based Apps for Teaching Socio-Emotional Skills to Individuals on the Autism Spectrum: A Systematic Review of the Smartphone MarketsNo
Enhancing Communication Skills in Students with Autism: A UAE Case Study on iPad-Based InterventionsYes
Using EEG and Eye Tracking to Evaluate an Emotion Recognition iPad App for Autistic ChildrenNo
Developing self-engagement skills on a tablet in children with autism spectrum disorder using activity schedulesNo
Robotics as a tool for STEM inclusion: Implementation of an after-school robotics program for students with Autism spectrum DisorderNo
Zirkus Empathico 2.0: a multiplayer serious mobile game for children with autism spectrum disorder (ASD), with a focus on enhancing social and emotional developmentYes
Digital Horizons: Enhancing Autism Support with Augmented RealityNo
Insights from user experience and evaluation of a mobile health nutrition intervention for children with autism: A qualitative studyNo
Social attention in the wild—fixations to the eyes and autistic traits during a naturalistic interaction in a healthy sampleNo
EMooly: Supporting Autistic Children in Collaborative Social-Emotional Learning with Caregiver Participation through Interactive AI-infused and AR ActivitiesYes
Innovative Approach to Detecting Autism Spectrum Disorder Using Explainable Features and Smart Web ApplicationNo
Using music to assist language learning in autistic children with minimal verbal language: The MAP feasibility RCTNo
MOLHEM: An innovative android application with an interactive avatar-based chatbot for Arab children with ASDNo
Design and Evaluation of a Mobile Robotic Assistant for Emotional Learning in Individuals with ASD: Expert Evaluation StageNo
The impact of coping behaviors on perceived competence and social anxiety in the everyday social engagement of autistic adolescentsNo
Development of oral health resources and a mobile app for caregivers and autistic children through consensus buildingNo
Effectiveness of IMPUTE ADT-1 mobile application in children with autism spectrum disorder: An interim analysis of an ongoing randomized controlled trialNo
Enhancing emotion recognition in young autistic children with or without attention-deficit/hyperactivity disorder in Hong Kong using a Chinese App version of The TransportersNo
The emotional support plan: Feasibility trials of a brief, telehealth-based mobile intervention to support coping for autistic adultsNo
Co-Design of Collaboration Monitoring Apps for Teachers to support Children with Autism in Religious EducationNo
Using mobile health technology to assess childhood autism in low-resource community settings in India: An innovation to address the detection gapNo
Mobile Application for Children with Asperger’s Syndrome that Improves Social Interaction with Augmented RealityNo
State of the art of intervention techniques for the social skills training of workers with neurodevelopmental disorders | État des lieux des techniques d’intervention pour l’entraînement des habiletés sociales de travailleurs présentant un trouble neurodéveloppementalNo
Experimental analysis of voice volume for children with autism spectrum disorderYes
Training work-related social skills in adults with Autism Spectrum Disorder using a tablet-based interventionNo
An online survey of educators’ views regarding iPad practices for enhancing the social communication and emotional regulation of pupils with autism in special and mainstream schoolsNo
A Preliminary Curriculum to Promote Social Skills via Social Narratives and App Development in Youth With AutismNo
Augmentative and alternative communication in autism spectrum disorder: transitioning from letter board to iPad—a case studyNo
Enhancing Communication for People with Autism Through the Design of a Context-aware Mobile Application for PECSNo
Network analysis of autism traits and problematic mobile phone use and their associations with depression among Chinese college studentsNo
Case report: Receptive labeling training in autism: conventional vs. technology-based approaches? a single case studyNo
Development of personalized profiles of students with autism spectrum disorder for interactive interventions with robots to enhance language and social skillsNo
The Use of Digital Interventions for Children and Adolescents with Autism Spectrum Disorder—A Meta-AnalysisNo
Characterizing Autism Spectrum Disorder Through Fusion of Local Cortical Activation and Global Functional Connectivity Using Game-Based Stimuli and a Mobile EEG SystemNo
Validation of PleaseApp: a digital tool for the assessment of receptive pragmatic abilities in children with neurodevelopmental disordersNo
Artificial Intelligence for Enhancing Special Education for K-12: A Decade of Trends, Themes, and Global Insights (2013–2023)No
Exploring the design space of virtual tutors for children with autism spectrum disorderNo
Patterns and impact of technology use in autistic childrenNo
Preliminary study on the application of mobile terminal in the early screening for autism spectrum disorder in children at home|移动终端在家庭儿童自闭症谱系障碍早期筛查中的应用初步研究No
Teaching Children with Autism Spectrum Disorder to Answer Questions Using an iPad-Based Speech-Generating DeviceYes
Teaching Two Autistic Children to Request Continuation of Social Routines with Their Parents Using an iPad®-Based Speech-Generating DeviceYes
Aawn: An Interactive Mobile Application for Improving the Communication Skills of Arab Children with AutismNo
The Assistive Technology for Teaching and Learning of Social Skills for Autism Spectrum Disorder Children: Multimedia Interactive Social Skills Module ApplicationNo
Relationship between quantitative digital behavioral features and clinical profiles in young autistic childrenNo
Mobile and online consumer tools to screen for autism do not promote equityNo
Randomized controlled pilot study of an app-based intervention for improving social skills, face perception, and eye gaze among youth with autism spectrum disorderNo
Early diagnosis of autism using indian autism grading toolNo
The Use of a PECS-based Electronic Communication Application in Working with Children with Developmental Disabilities. Case Study|Испoльзoвание электрoннoгo кoммуникативнoгo прилoжения на oснoве PECS в рабoте с детьми с нарушениями развития. Кейс-исследoваниеNo
A Protocol for the Development and Assessment of a Non-Pharmacological Intervention Designed to Improve Cognitive Skills of Adults with Intellectual Disabilities: A Mixed Method DesignNo
Apps to Teach Social Skills to Individuals with Autism Spectrum Disorder: A Review of the Embedded Behaviour Change ProceduresNo
“Going Mobile”-increasing the reach of parent-mediated intervention for toddlers with ASD via group-based and virtual deliveryNo
ILAT (Software as a Service): Interactive Learning Application Tool for Autism Screening and Assessment in children with Autism Spectrum DisorderNo
FRIDA, a Framework for Software Design, Applied in the Treatment of Children with Autistic DisorderNo
Does playing on a digital tablet impact the social interactions of children with autism spectrum disorder? | Jouer sur une tablette numérique a-t-il un impact sur les interactions sociales des enfants avec un trouble du spectre de l’autisme ?No
Using digital social stories to improve social skills in children with autism: a pilot experimental single-subject studyNo
Blocking of Stimulus Control in Children with AutismNo
PlanTEA: Supporting Planning and Anticipation for Children with ASD Attending Medical AppointmentsNo
Portable Joint Attention Skill Training Platform for Children With AutismNo
Self-Directed Video Prompting with and without Voice-Over Narration in Teaching Daily Living Skills to Students with Autism Spectrum DisorderNo
Teaching on-Topic Conversational Responses to Students with Autism Spectrum Disorders Using an iPad AppYes
Evaluating the effectiveness of an autism-specific public transport app for individuals on the autism spectrum: a pilot studyNo
The effects of AAC video visual scene display technology on the communicative turns of preschoolers with autism spectrum disorderYes
A Guideline for Designing Mobile Applications for Children with Autism within Religious BoundariesNo
Autistic Innovative Assistant (AIA): an Android application for Arabic autism childrenNo
Developmental Assessment of American Jewish Belonging Behaviour with Special Reference to Autism Spectrum Disorder—A Case StudyNo
An AI-Enabled Internet of Things Based Autism Care System for Improving Cognitive Ability of Children with Autism Spectrum DisordersNo
The need for and barriers to using assistive technologies among individuals with Autism Spectrum Disorders in ChinaNo
Behavioral assessment and faded bedtime intervention for delayed sleep-onset in an adult with autism spectrum disorderNo
A Multimodal Messaging App (MAAN) for Adults with Autism Spectrum Disorder: Mixed Methods Evaluation StudyNo
An mCARE study on patterns of risk and resilience for children with ASD in BangladeshNo
A randomised controlled feasibility trial of music-assisted language telehealth intervention for minimally verbal autistic children—the MAP study protocolNo
Autism spectrum disorders: Analysis of mobile elements at 7q11.23 williams–beuren region by comparative genomicsNo
Digital Interventions for Autism Spectrum Disorder: A Meta-analysisNo
Assessing Video Enhanced Activity Schedules to Teach Social Skills to Children with Autism Spectrum DisorderNo
Technology-Aided Instruction and Intervention in Teaching Students With Autism to Make InferencesNo
Aberrant behavior prediction and severity analysis for autistic child through deep transfer learning to avoid adverse drug effectNo
Development of a Mobile App to Improve Numeracy Skills of Children with Autism Spectrum Disorder: Participatory Design and Usability StudyNo
Research on contactless bio-signal measurement technology for improving social awareness of individuals with communication challengesNo
Examining the Effectiveness of WhatsApp-Based Spiritual Posts on Mitigating Stress and Building Resilience, Maternal Confidence and Self-efficacy Among Mothers of Children with ASDNo
The efficacy of wechat-based parenting training on the psychological well-being of mothers with children with autism during the COVID-19 pandemic: Quasi-experimental studyNo
What do digital tools add to classical tools for sociocommunicative and adaptive skills in children with Autism Spectrum Disorder?No
Use of Mobile Social Story Maps in the Development of Cognitive and Social Skills of Children With Autism Spectrum DisorderYes
ASD Children’s APP Emotional Interaction Design Based on Smart Toys of Internet of ThingsNo
Brief Report: Collateral Joint Engagement During a Playdate Intervention for Children with and at Risk for AutismNo
Perceptions of friendship among girls with Autism Spectrum DisordersNo
The development of an escape room–based serious game to trigger social interaction and communication between high-functioning children with autism and their peers: Iterative design approachNo
An Immersive Computer-Mediated Caregiver-Child Interaction System for Young Children with Autism Spectrum DisorderNo
Improving screening systems of autism using data samplingNo
Autonomy-supportive treatment for acquired apraxia of speech: feasibility and therapeutic effectNo
Feasibility of an app-based parent-mediated speech production intervention for minimally verbal autistic children: development and pilot testing of a new interventionNo
POMA: A tangible user interface to improve social and cognitive skills of Sri Lankan children with ASDNo
The effects of augmented reality on social skills in children with autism spectrum disorderYes
The effects of social robots on the social skills of children with autism spectrum disorder: A Meta-analysisNo
The use of mobile applications to improve social communication in children with autism spectrum disorderNo
A systematic review of mobile health apps for autism spectrum disorderNο
The role of parent-mediated interventions using mobile technology in the early intervention for autism spectrum disorderNo
A review of the use of augmentative and alternative communication (AAC) devices in children with autism spectrum disorder.No
Coping, Daily Hassles and Behavior and Emotional Problem in Adolescents with High-Functioning Autism/Asperger’s DisorderNo
Randomized controlled pilot study of an app-based intervention for improving social skills, face perception, and eye gaze among youth with autism spectrum disorderNo
A priliminary curriculum to promote social skills via social narratives and app development in youth with autismNo
Status YES: This paper integrates all the inclusion criteria of our review: (a) participants must have been diagnosed with autism; (b) participants must not have any other kind of disorder or disability such as Tourette syndrome, visual impairments, hearing loss, ADHD, etc.; (c) studies must have been published in scientific reviews; (d) participants must have taken part in an intervention that included at least one mobile application; (e) the intervention must have been planned to focus on social skills; (f) studies must have been published between 2020 and December 2025; (g) the ages of the children participating in the interventions must be between 2 and 12 years. Status NO: Does not integrate one or more inclusion criteria.

Appendix B

Section and TopicItem #Checklist ItemLocation Where Item Is Reported
TITLE
Title 1Identify the report as a systematic review.1
ABSTRACT
Abstract 2See the PRISMA 2020 for Abstracts checklist.1
INTRODUCTION
Rationale 3Describe the rationale for the review in the context of existing knowledge.1–4
Objectives 4Provide an explicit statement of the objective(s) or question(s) the review addresses.1
METHODS
Eligibility criteria 5Specify the inclusion and exclusion criteria for the review and how studies were grouped for the syntheses.5–6
Information sources 6Specify all databases, registers, websites, organisations, reference lists and other sources searched or consulted to identify studies. Specify the date when each source was last searched or consulted.4
Search strategy7Present the full search strategies for all databases, registers and websites, including any filters and limits used.4–5
Selection process8Specify the methods used to decide whether a study met the inclusion criteria of the review, including how many reviewers screened each record and each report retrieved, whether they worked independently, and if applicable, details of automation tools used in the process.4–6
Data collection process 9Specify the methods used to collect data from reports, including how many reviewers collected data from each report, whether they worked independently, any processes for obtaining or confirming data from study investigators, and if applicable, details of automation tools used in the process.6–7
Data items 10aList and define all outcomes for which data were sought. Specify whether all results that were compatible with each outcome domain in each study were sought (e.g., for all measures, time points, analyses), and if not, the methods used to decide which results to collect.2, 5
10bList and define all other variables for which data were sought (e.g., participant and intervention characteristics, funding sources). Describe any assumptions made about any missing or unclear information.7
Study risk of bias assessment11Specify the methods used to assess risk of bias in the included studies, including details of the tool(s) used, how many reviewers assessed each study and whether they worked independently, and if applicable, details of automation tools used in the process.16–17
Effect measures 12Specify for each outcome the effect measure(s) (e.g., risk ratio, mean difference) used in the synthesis or presentation of results.7, 20
Synthesis methods13aDescribe the processes used to decide which studies were eligible for each synthesis (e.g., tabulating the study intervention characteristics and comparing against the planned groups for each synthesis (item #5)).19
13bDescribe any methods required to prepare the data for presentation or synthesis, such as handling of missing summary statistics, or data conversions.7
13cDescribe any methods used to tabulate or visually display results of individual studies and syntheses.9–15, 17
13dDescribe any methods used to synthesize results and provide a rationale for the choice(s). If meta-analysis was performed, describe the model(s), method(s) to identify the presence and extent of statistical heterogeneity, and software package(s) used.7, 17–19
13eDescribe any methods used to explore possible causes of heterogeneity among study results (e.g., subgroup analysis, meta-regression).19, 24
13fDescribe any sensitivity analyses conducted to assess robustness of the synthesized results.7
Reporting bias assessment14Describe any methods used to assess risk of bias due to missing results in a synthesis (arising from reporting biases).7
Certainty assessment15Describe any methods used to assess certainty (or confidence) in the body of evidence for an outcome.N/A
RESULTS
Study selection 16aDescribe the results of the search and selection process, from the number of records identified in the search to the number of studies included in the review, ideally using a flow diagram.5–6
16bCite studies that might appear to meet the inclusion criteria, but which were excluded, and explain why they were excluded.5
Study characteristics 17Cite each included study and present its characteristics.19–23
Risk of bias in studies 18Present assessments of risk of bias for each included study.16–17
Results of individual studies 19For all outcomes, present, for each study: (a) summary statistics for each group (where appropriate) and (b) an effect estimate and its precision (e.g., confidence/credible interval), ideally using structured tables or plots.9–15
Results of syntheses20aFor each synthesis, briefly summarise the characteristics and risk of bias among contributing studies.17–23
20bPresent results of all statistical syntheses conducted. If meta-analysis was done, present for each the summary estimate and its precision (e.g., confidence/credible interval) and measures of statistical heterogeneity. If comparing groups, describe the direction of the effect.17–19
20cPresent results of all investigations of possible causes of heterogeneity among study results.24
20dPresent results of all sensitivity analyses conducted to assess the robustness of the synthesized results.N/A
Reporting biases21Present assessments of risk of bias due to missing results (arising from reporting biases) for each synthesis assessed.N/A
Certainty of evidence 22Present assessments of certainty (or confidence) in the body of evidence for each outcome assessed.N/A
DISCUSSION
Discussion 23aProvide a general interpretation of the results in the context of other evidence.23–24
23bDiscuss any limitations of the evidence included in the review.24–35
23cDiscuss any limitations of the review processes used.24–24
23dDiscuss implications of the results for practice, policy, and future research.24–25
OTHER INFORMATION
Registration and protocol24aProvide registration information for the review, including register name and registration number, or state that the review was not registered.4
24bIndicate where the review protocol can be accessed, or state that a protocol was not prepared.4
24cDescribe and explain any amendments to information provided at registration or in the protocol.N/A
Support25Describe sources of financial or non-financial support for the review, and the role of the funders or sponsors in the review.25
Competing interests26Declare any competing interests of review authors.25
Availability of data, code and other materials27Report which of the following are publicly available and where they can be found: template data collection forms; data extracted from included studies; data used for all analyses; analytic code; any other materials used in the review.27
From: (Page et al., 2021). This work is licensed under CC BY 4.0. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/ (accessed on 26 October 2026).

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