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Improving Hemorrhoid Outcomes: Best Practices for Pharmacists
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Medical Cannabis Use and Healthcare Utilization Among Patients with Chronic Pain: A Causal Inference Analysis Using TMLE
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Outcomes of Pharmacists in Cardiac Arrest and Trauma Resuscitations: A Scoping Review
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Lysergic Acid Amide (LSA), an LSD Analog: Systematic Review of Pharmacological Effects, Adverse Outcomes, and Therapeutic Potentials
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Accuracy and Safety of ChatGPT-3.5 in Assessing Over-the-Counter Medication Use During Pregnancy: A Descriptive Comparative Study
Journal Description
Pharmacy
Pharmacy
is an international, scientific, peer-reviewed, and open access journal dealing with pharmacy education and practice, and is published bimonthly online by MDPI. The Academy of Pharmaceutical Sciences (APS) is affiliated with Pharmacy and its members receive discounts on the article processing charges.
- Open Access— free for readers, with article processing charges (APC) paid by authors or their institutions.
- High Visibility: indexed within ESCI (Web of Science), PubMed, PMC, Embase, and other databases.
- Rapid Publication: manuscripts are peer-reviewed and a first decision is provided to authors approximately 23.9 days after submission; acceptance to publication is undertaken in 3 days (median values for papers published in this journal in the first half of 2025).
- Recognition of Reviewers: Reviewers who provide timely, thorough peer-review reports receive vouchers entitling them to a discount on the APC of their next publication in any MDPI journal, in appreciation of the work done.
- Journal Clusters-Pharmaceutical Science: Scientia Pharmaceutica, Pharmaceuticals, Pharmaceutics, Pharmacy, Future Pharmacology, Pharmacoepidemiology, Drugs and Drug Candidates and Journal of Pharmaceutical and BioTech Industry.
Impact Factor:
1.8 (2024);
5-Year Impact Factor:
2.0 (2024)
Latest Articles
Knowledge, Attitudes and Behaviours Towards Alcohol Consumption and Cardiovascular Health Among Healthcare Students of South Asian Heritage in the UK: A Qualitative Study
Pharmacy 2025, 13(5), 136; https://doi.org/10.3390/pharmacy13050136 - 18 Sep 2025
Abstract
Background: Cardiovascular disease is a leading cause of mortality in England, with South Asians estimated to have a higher risk of CVD development compared to the general population. Harmful drinking is a key risk factor for cardiovascular disease, but little is known about
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Background: Cardiovascular disease is a leading cause of mortality in England, with South Asians estimated to have a higher risk of CVD development compared to the general population. Harmful drinking is a key risk factor for cardiovascular disease, but little is known about drinking behaviours among South Asians, especially those aged 18–25. Objectives: The objectives of this study were (i) to investigate the knowledge of the cardiovascular effects of harmful drinking among young South Asians aged 18–25, and (ii) to explore the perceptions of young South Asians towards the role of the pharmacist in supporting individuals with alcohol-related harm. Methods: Qualitative, in depth, face-to-face, semi-structured interviews were conducted with ten young South Asians, around 30 min in length. The interviews were audio recorded, transcribed verbatim and then thematically analysed. Results: Four superordinate themes emerged: (1) Culture Clash; (2) The Great Escape; (3) Cardiovascular Confusion; and (4) The Ambiguous Pharmacist. These themes highlighted a dichotomy between the drinking behaviours among different South Asian communities, a lack of knowledge regarding the cardiovascular consequences of harmful drinking and mixed views regarding pharmacists’ role in supporting dependence. Participants acknowledged the prevalence of poor cardiovascular health among British South Asians, citing various types of dysfunction and possible causes; however, the effect of drinking specifically was not understood. Most participants would refer a young person struggling with dependence to a pharmacist and would be receptive to discussing drinking with one. However, few commented on any role outside of signposting to other services or healthcare providers. Conclusions: Greater cardiovascular health promotion is needed among South Asians, with an emphasis on the link between excess alcohol consumption and cardiovascular dysfunction. Furthermore, pharmacists must do more to promote greater awareness of the different ways in which alcohol dependence can be supported within the community to encourage young people seeking harm reduction to utilise those services as needed.
Full article
(This article belongs to the Section Pharmacy Practice and Practice-Based Research)
Open AccessArticle
Perceived Knowledge and Confidence of Beta-Lactam Allergy Management Among Pharmacy Students on Advanced Pharmacy Practice Experiences
by
Jamie L. Wagner, David R. Oliver, Bruce M. Jones, Kayla R. Stover, Misha T. Watts, Wesley D. Kufel, Lena McDowell, Edoabasi U. McGee, T. Lynn Stevenson and Christopher M. Bland
Pharmacy 2025, 13(5), 135; https://doi.org/10.3390/pharmacy13050135 - 18 Sep 2025
Abstract
Pharmacist engagement in allergy clarification has demonstrated increased appropriate antibiotic use. The purpose of this study was to determine the knowledge and confidence of pharmacy students in their final professional year regarding beta-lactam (BL) allergies. Students from 5 schools of pharmacy participated in
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Pharmacist engagement in allergy clarification has demonstrated increased appropriate antibiotic use. The purpose of this study was to determine the knowledge and confidence of pharmacy students in their final professional year regarding beta-lactam (BL) allergies. Students from 5 schools of pharmacy participated in a 22-question survey pertaining to experience with drug allergies, knowledge of BL allergies, and confidence regarding BL allergy management. Data were summarized among all respondents and further analyzed by infectious disease (ID) interest. A total of 160/521 students responded to the survey (31%). Most students (73%) had no course dedicated to drug allergies; however, 84% indicated the topic was taught within the curriculum. Students with an ID interest had a higher perceived knowledge regarding the details of penicillin skin testing (62% vs. 32%), clinical implications of penicillin skin test results (87% vs. 70%), and the principles behind a graded and direct penicillin challenge (64% vs. 41%). These students were more confident in educating patients about a perceived penicillin allergy (34% vs. 15%). Perceived knowledge and confidence of BL allergies were low, especially in high-level interventions. Targeted training in beta-lactam allergy recognition and management within the curriculum should be considered to improve upon these findings.
Full article
(This article belongs to the Section Pharmacy Education and Student/Practitioner Training)
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Open AccessArticle
A Revised Mixed-Approach Rubric for the Quality of Academic Posters
by
Michael J. Peeters, Megan A. Kaun and Kimberly A. Schmude
Pharmacy 2025, 13(5), 134; https://doi.org/10.3390/pharmacy13050134 - 17 Sep 2025
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The quality of posters at pharmacy conferences can vary. We created a mixed-approach rubric (MAR) for poster quality. Evidence from multiple sources (systematic review, further analysis of rater scores, verbal feedback from raters) showed the need to slightly modify that MAR, which we
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The quality of posters at pharmacy conferences can vary. We created a mixed-approach rubric (MAR) for poster quality. Evidence from multiple sources (systematic review, further analysis of rater scores, verbal feedback from raters) showed the need to slightly modify that MAR, which we accomplished. Our objectives here were to re-evaluate scoring using this revised MAR (rMAR) and to further examine the attributes of lower-quality versus higher-quality posters. Two faculty raters independently scored each poster using the rMAR for recent posters presented at a pharmacy education conference. The Rasch Measurement Model provided psychometric evidence and poster-quality measures. These measures were then linear-regressed with attributes of logical sequencing, QR-code presence/use, submission abstract presence, and wordiness. Moreover, Traditional vs. Contemporary poster formats were compared. Raters scored 642 posters (267 from 2023, 375 from 2024). The Rasch Measurement Model showed a distinct separation of posters into lower quality versus higher quality. The rMAR’s rating scale continued to function well (like the original MAR had) among multiple raters. Poster-quality measures were significantly positive when linearly regressed with logical sequencing, QR-code presence/use, absence of submission abstract, and decreased wordiness. Moreover, Contemporary poster formats (either Persky-style or Billboard-style) were higher quality on average than Traditional poster formats. This evidence-based rMAR showed a helpful validation of poster-quality scores. Regression confirmed findings from the initial MAR (before revision), and choice of poster format proved a notable decision affecting poster quality.
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Open AccessArticle
Developing a Theoretically Informed Strategy to Enhance Pharmacist-Led Deprescribing in Care Homes for Older People
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Linda Birt, David Wright, David P. Alldred, Christine M. Bond, Richard Holland, Carmel Hughes and Sion Scott
Pharmacy 2025, 13(5), 133; https://doi.org/10.3390/pharmacy13050133 - 16 Sep 2025
Abstract
Polypharmacy is prevalent in older people residing in care homes. Deprescribing, reducing or stopping harmful or unnecessary medicines, leads to improvements in patient- and health-system-orientated outcomes. This study identified the barriers and enablers to pharmacists proactively deprescribing in United Kingdon care homes. It
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Polypharmacy is prevalent in older people residing in care homes. Deprescribing, reducing or stopping harmful or unnecessary medicines, leads to improvements in patient- and health-system-orientated outcomes. This study identified the barriers and enablers to pharmacists proactively deprescribing in United Kingdon care homes. It draws on methods from behavioural science. Twenty-nine participants who had previously taken part in a deprescribing randomised control trial (sixteen pharmacists, six primary care doctors, and seven care home managers) were interviewed. Data were mapped to the Theoretical Domains Framework to understand pharmacists’ deprescribing behaviour. Barriers were deprescribing seen as risky and perceived resistance to deprescribing by residents, their families, and care home staff. Enablers were seeing benefits from deprescribing, part of a pharmacists’ role, and endorsement from a doctor. Ways to change pharmacist behaviour were identified from a suite of behaviour change techniques (BCT). Using a modified Nominal Group Technique, 15 staff (six pharmacists, five primary care doctors, and four care home managers) naïve to deprescribing interventions completed an online survey to assess the feasibility and acceptability of implementing the 27 BCTs. Seven BCTs achieved a more that 80% consensus on all implementation criteria. In a consensus workshop, the staff group discussed practical ways the BCTs might work in primary care practice. Fourteen UK policy and practice leaders worked with the researchers to develop recommendations from the consensus workshop into a policy briefing. In conclusion, this study provides detail on using a theory-informed approach to translate research into policy to inform deprescribing practices.
Full article
(This article belongs to the Section Pharmacy Practice and Practice-Based Research)
Open AccessArticle
Scaffolded Medication Therapy Management in a Pharmacy Skills Laboratory: A Structured Approach to Skill Development
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Kimberley J. Begley, Molly C. Goessling, Tara M. Eickhoff and Timothy P. Ivers
Pharmacy 2025, 13(5), 132; https://doi.org/10.3390/pharmacy13050132 - 15 Sep 2025
Abstract
Pharmacists are increasingly expected to deliver medication therapy management (MTM) services, yet many pharmacy students report insufficient confidence and preparedness in executing these complex tasks. This study evaluated a scaffolded MTM instructional series integrated into a second-year pharmacy skills laboratory, aiming to enhance
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Pharmacists are increasingly expected to deliver medication therapy management (MTM) services, yet many pharmacy students report insufficient confidence and preparedness in executing these complex tasks. This study evaluated a scaffolded MTM instructional series integrated into a second-year pharmacy skills laboratory, aiming to enhance student competence through progressive, structured learning. A mixed-methods design assessed changes in self-reported confidence, performance-based outcomes, and reflective insights among 154 students across three educational tracks. The 14-week intervention included sequential activities such as medication history interviews, drug-related problem (DRP) identification, care plan development, and comprehensive MTM simulations. Pre- and post-intervention surveys revealed statistically significant improvements in all 18 confidence domains, with the greatest gains in therapeutic recommendations and prescriber communication. Effect sizes ranged from small to very large (Cohen’s d 0.33–1.05), indicating gains that were both statistically reliable and educationally meaningful. Performance assessments showed consistent proficiency across MTM components, with average scores ranging from 90% to 96%. Qualitative reflections reinforced these findings, highlighting growth in communication, individualized patient care, and professional identity formation. The scaffolded approach aligns with accreditation standards and instructional design theory, offering a model for pharmacy curricula. Despite limitations such as lack of a comparator group and potential response bias, the study demonstrates that scaffolded MTM instruction effectively supports skill acquisition and confidence, preparing students for real-world clinical practice.
Full article
(This article belongs to the Section Pharmacy Education and Student/Practitioner Training)
Open AccessArticle
Pharmacist Dispensing of Mifepristone: Evaluation of Knowledge and Support Before and After a Continuing Education Course
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Natalie Morris, Alexa Orosz, M. Antonia Biggs, Sally Rafie and Daniel Grossman
Pharmacy 2025, 13(5), 131; https://doi.org/10.3390/pharmacy13050131 - 15 Sep 2025
Abstract
Medication abortion with mifepristone and misoprostol is a safe and effective method for ending a pregnancy. Pharmacy dispensing of mifepristone was approved by the U.S. Food and Drug Administration in 2023, but educational opportunities for pharmacists were nonexistent. We designed a 1 h
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Medication abortion with mifepristone and misoprostol is a safe and effective method for ending a pregnancy. Pharmacy dispensing of mifepristone was approved by the U.S. Food and Drug Administration in 2023, but educational opportunities for pharmacists were nonexistent. We designed a 1 h continuing education course on medication abortion for pharmacists, which was offered in a live-webinar or recorded-video format over 3 years. It included key medication abortion topics, including medications, patient counseling, relevant policies, and implementing pharmacy dispensing. Using a prepost design, we administered online surveys to participants prior to and after completing the course to assess changes in overall medication abortion knowledge score (six items, Cronbach’s alpha = 0.76) and support for pharmacist dispensing of medication abortion (one Likert-scaled item). During the study period, 279 students and pharmacists took the course, of which 148 completed both the pre- and post-course questionnaires. Adjusted regression analyses demonstrated significant increases in knowledge scores and support for pharmacist dispensing of medication abortion post-course; most thought dispensing mifepristone would be very (21.6%) or somewhat easy (38.5%) to implement, and 75% indicated a willingness to dispense mifepristone if allowed. These findings suggest that video-based education on medication abortion is an effective tool for enhancing pharmacists’ knowledge and support for medication abortion, which could increase access to reproductive health care.
Full article
(This article belongs to the Special Issue Pharmacy Practice for Women’s/Reproductive Health)
Open AccessArticle
Pharmacist-Led Prescribing in Austria: A Mixed-Methods Study on Clinical Readiness and Legal Frameworks
by
Olaf Rose, Clarissa Egel, Johanna Pachmayr and Stephanie Clemens
Pharmacy 2025, 13(5), 130; https://doi.org/10.3390/pharmacy13050130 - 8 Sep 2025
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In Austria, community pharmacists may dispense prescription-only drugs in exceptional emergency cases. Hospital pharmacists are permitted to adapt or discontinue therapy with prior physician approval. This mixed-methods study explores how Austrian pharmacists interpret and apply these frameworks, their readiness for expanded roles, and
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In Austria, community pharmacists may dispense prescription-only drugs in exceptional emergency cases. Hospital pharmacists are permitted to adapt or discontinue therapy with prior physician approval. This mixed-methods study explores how Austrian pharmacists interpret and apply these frameworks, their readiness for expanded roles, and the systemic conditions required to support broader clinical engagement. A cross-sectional design was used with two online surveys targeting community and hospital pharmacists. Additionally, 15 semi-structured interviews were conducted (ten community, five hospital pharmacists). Quantitative data were analyzed descriptively; qualitative data were examined using Mayring’s content analysis. Data integration followed a triangulation design via mixed-methods matrices. A total of 238 community and 53 hospital pharmacists responded. Findings show that community pharmacists frequently apply clinical judgment in urgent situations and navigate regulatory grey zones. Over 88% support expanded roles, particularly in continuing contraceptives, managing chronic diseases, and treating infections using point-of-care testing. Hospital pharmacists report limited implementation of their framework, hindered by institutional inertia, staffing shortages, and poor access to patient data. Confidence in clinical pharmacotherapy decisions was limited. Targeted training and policy support are essential.
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Open AccessArticle
Assessing Prescribing Patterns of Nonstatins as Add-on Therapy for Secondary Prevention in a Federally Qualified Health Center
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Sabrina Guerra, Kathryn P. Lin, Ahmed S. Kenawy, Chanhyun Park and Morgan P. Stewart
Pharmacy 2025, 13(5), 129; https://doi.org/10.3390/pharmacy13050129 - 6 Sep 2025
Abstract
Background: Lipid management is a key aspect of secondary atherosclerotic cardiovascular disease (ASCVD) prevention. However, real-world studies show that ~72–88% of patients with ASCVD fail to meet their low-density lipoprotein cholesterol (LDL-C) target. Nonstatin agents are available as add-on therapies that can be
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Background: Lipid management is a key aspect of secondary atherosclerotic cardiovascular disease (ASCVD) prevention. However, real-world studies show that ~72–88% of patients with ASCVD fail to meet their low-density lipoprotein cholesterol (LDL-C) target. Nonstatin agents are available as add-on therapies that can be utilized when maximally tolerated statins are insufficient to achieve LDL-C goals. This retrospective study aimed to evaluate the current prescribing habits of nonstatins as add-on therapy to statins for secondary ASCVD prevention at a federally qualified health center (FQHC). Methods: Patients were included if they had a history of clinical ASCVD, ≥1 lipid panel obtained during the study period, and were prescribed any intensity statin. Results: Among 398 included participants, 11.1% were prescribed nonstatin therapy and 35.9% were meeting a LDL-C target of <70 mg/dL. There was a significant association between being prescribed ezetimibe based on the type of healthcare coverage (p = 0.04) and a higher number of ASCVD qualifying indications (p < 0.01). Conclusions: Overall, nonstatins were found to be underutilized for LDL-C management in this underserved population. Future initiatives should target ways to optimize nonstatin therapy to optimize secondary ASCVD prevention.
Full article
(This article belongs to the Section Pharmacy Practice and Practice-Based Research)
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Open AccessArticle
Semaglutide in the Real World: Attitudes of the Population
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Doris Rušić, Toni Durdov, Ivona Jadrijević, Ana Šešelja Perišin, Dario Leskur, Joško Božić, Mila Marie Klusmeier and Josipa Bukić
Pharmacy 2025, 13(5), 128; https://doi.org/10.3390/pharmacy13050128 - 4 Sep 2025
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Background: Clinical experience with semaglutide in patients with type 2 diabetes mellitus shows that its benefits extend far beyond glucose regulation. This study examines whether this drug is indeed popular among the Croatian population and explores whether factors such as gender or proximity
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Background: Clinical experience with semaglutide in patients with type 2 diabetes mellitus shows that its benefits extend far beyond glucose regulation. This study examines whether this drug is indeed popular among the Croatian population and explores whether factors such as gender or proximity to the healthcare sector influence its potential use, attitudes toward weight loss, and knowledge regarding its application and possible adverse effects. Methods: This was a cross-sectional population study. In this study we focused on the brand name Ozempic® for semaglutide as it is the most commonly searched term for semaglutide. Results: The study included 290 participants, most of who were women (N = 243, 83.8%). As many as 214 (73.8%) people stated they had heard of Ozempic®; however, there was no significant difference in whether people had heard of Ozempic® if they had type 2 diabetes mellitus (p = 0.415). In total, 23.4% of people stated they knew someone who took Ozempic®. Women were significantly more likely to feel pressure about their appearance than men, with 51.1% of men reporting no pressure at all compared to only 39.9% of women (p = 0.015). A majority of participants agreed that social media strongly affects perception on the use of medications for weight loss (73.8%). Individuals with a family member in the healthcare field were significantly more informed about the possible adverse reactions of semaglutide compared to those without such a connection. Among participants without a healthcare professional in the family, 75.0% reported being unaware of potential adverse effects, compared to 47.9% of those with a family member in healthcare. Moreover, participants with a healthcare professional in the family were more likely to know the correct route of administration for Ozempic® (68.1% vs. 54.6%, p = 0.025); Conclusions: The results of this study show that three-quarters of people had heard of Ozempic®, regardless of whether they had an indication for its use or not. In addition, the results indicate that although both men and women share satisfaction with their bodies, women feel more pressured by societal expectations related to their appearance.
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Open AccessArticle
Self-Medication: Attitudes and Behaviors Among Pharmacy and Medical Students
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George Jîtcă, Carmen-Maria Jîtcă, Mădălina-Georgiana Buț and Camil-Eugen Vari
Pharmacy 2025, 13(5), 127; https://doi.org/10.3390/pharmacy13050127 - 4 Sep 2025
Abstract
Self-medication is increasingly prevalent among healthcare students, raising concerns about the adequacy of current medical education in promoting safe medication practices. This study aimed to assess the frequency, motivations, and perceptions of self-medication among medical and pharmacy students and to identify educational gaps.
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Self-medication is increasingly prevalent among healthcare students, raising concerns about the adequacy of current medical education in promoting safe medication practices. This study aimed to assess the frequency, motivations, and perceptions of self-medication among medical and pharmacy students and to identify educational gaps. A cross-sectional survey was conducted using a structured, anonymous questionnaire distributed to medical and pharmacy students at a single academic institution. The questionnaire assessed self-medication frequency, substances used, motivations, perceived risks, confidence in knowledge, sources of information, and attitudes toward curriculum improvements. Over 50% of participants reported practicing self-medication at least once a month. The most commonly used substances were analgesics and dietary supplements. Main motivations included recognition of symptoms, confidence in personal knowledge, and avoidance of waiting times. Despite receiving university instruction on self-medication risks, students continued to self-medicate, with many relying on the internet as a primary source of information. Only 8% felt very confident in counseling patients on self-medication. A majority (over 70%) expressed a strong interest in integrating dedicated educational modules into the curriculum. There is a clear need for improved, practice-oriented education on self-medication. Future interventions should focus on interdisciplinary teaching, digital literacy, and simulation-based training to foster safer medication practices.
Full article
Open AccessArticle
Implementing a Functional Group Analysis Activity to Support Student Learning in Medicinal Chemistry: A Three-Year Experience
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Ansel Belani and Jitendra D. Belani
Pharmacy 2025, 13(5), 126; https://doi.org/10.3390/pharmacy13050126 - 4 Sep 2025
Abstract
Many pharmacy students begin medicinal chemistry with limited experience in chemical structure interpretation and reactivity patterns, making it difficult to connect foundational concepts to real-world drug behavior. We introduced a low-stakes functional group analysis activity that included peer discussion and a follow-up quiz
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Many pharmacy students begin medicinal chemistry with limited experience in chemical structure interpretation and reactivity patterns, making it difficult to connect foundational concepts to real-world drug behavior. We introduced a low-stakes functional group analysis activity that included peer discussion and a follow-up quiz to improve learning and reduce student anxiety. We studied the impact of this activity by comparing Exam 1 scores across three cohorts: one before the activity (2022) and two after implementation (2023 and 2024). The average Exam 1 scores improved in the post-intervention years, and while the overall difference across cohorts did not reach statistical significance, post hoc analysis revealed a significant improvement between the 2022 and 2024 cohorts. The students who engaged more deeply, especially those who performed well on the quiz, consistently earned higher exam scores, with strong positive correlations observed in both years. These results suggest that simple, low-stakes activities that focus on core concepts can promote engagement and support student success, even in challenging, content-heavy courses like medicinal chemistry.
Full article
(This article belongs to the Section Pharmacy Education and Student/Practitioner Training)
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Open AccessArticle
Do PCSK9 Inhibitors Impair Memory? A Dual Approach Combining Real-World Data and Genetic Evidence
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Xuezhong Shi, Shijia Wang, Yongli Yang, Xudong Xia, Jingwen Fan, Jingjing Wang, Nana Wang and Xiaocan Jia
Pharmacy 2025, 13(5), 125; https://doi.org/10.3390/pharmacy13050125 - 3 Sep 2025
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Emerging evidence suggested a potential link between lipid-lowering therapies and neurocognitive effects, raising concerns regarding the possible adverse impact of PCSK9 inhibitors on memory loss. We extracted adverse events associated with memory loss for PCSK9 inhibitors from the Food and Drug Administration Adverse
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Emerging evidence suggested a potential link between lipid-lowering therapies and neurocognitive effects, raising concerns regarding the possible adverse impact of PCSK9 inhibitors on memory loss. We extracted adverse events associated with memory loss for PCSK9 inhibitors from the Food and Drug Administration Adverse Event Reporting System (FAERS), covering the period from the first quarter (Q1) of 2022 to Q1 of 2025. Reporting odds ratio (ROR), Medicines and Healthcare Products Regulatory Agency (MHRA), empirical Bayesian geometric mean (EBGM), and information component (IC) were used for pharmacovigilance analysis. Drug target Mendelian randomization (MR) was utilized to assess the causal association between PCSK9 inhibitors and memory loss. A total of 389 occurrences of memory loss associated with PCSK9 inhibitors were recorded among 388 patients. In the pharmacovigilance analysis, memory loss did not show a significant signal for PCSK9 inhibitors in both the full dataset [ROR (95% CI): 0.79 (0.72, 0.88); PRR = 0.79, χ2 = 20.64; EBGM05 = 0.73; IC025 = −2.00] and the lipid-lowering targets dataset [ROR (95%CI): 0.59 (0.53, 0.66); PRR = 0.59, χ2 = 95.33; EBGM05 = 0.59; IC025 = −2.30]. The drug target MR revealed no causal association between PCSK9 inhibitors and memory loss (p < 0.05). The present study failed to establish a causal relationship between PCSK9 inhibitors and memory loss. By providing both real-world and genetic evidence, our findings might help alleviate concerns and support the notion that PCSK9 inhibitors were relatively safe regarding memory function.
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Open AccessReview
Empowering Pharmacists in Heartburn Management: Practical Insights for OTC Treatment and Self-Care
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Mary Barna Bridgeman, Ashok Hospattankar, Kamran Siddiqui and Nardine Nakhla
Pharmacy 2025, 13(5), 124; https://doi.org/10.3390/pharmacy13050124 - 2 Sep 2025
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Heartburn is a prevalent and frequently self-managed condition, with a myriad of over-the-counter (OTC) treatment options available for self-care. The potential for misinterpretation of drug labels and improper OTC medication selection may result in inadequate treatment, potential drug interactions, as well as medication
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Heartburn is a prevalent and frequently self-managed condition, with a myriad of over-the-counter (OTC) treatment options available for self-care. The potential for misinterpretation of drug labels and improper OTC medication selection may result in inadequate treatment, potential drug interactions, as well as medication overuse, misuse, or delay in seeking treatment for a more serious health condition. As highly accessible healthcare professionals, pharmacists play a crucial role in validating self-diagnoses, in guiding appropriate OTC medication selection and use, and in educating patients on both pharmacologic and non-pharmacologic management strategies for heartburn. It is essential for pharmacists to remain informed about the latest developments in disease management and treatment options. This narrative review provides an updated perspective on the epidemiology, risk factors, pathophysiology, and clinical manifestations associated with heartburn while underscoring the expanding role of pharmacists in patient care. This review includes a structured assessment framework and clinical management algorithm designed to enhance pharmacists’ ability to identify red flag symptoms, optimize OTC medication use, and facilitate timely referrals when necessary. By incorporating evidence-based guidance with patient-centered counseling, pharmacists can enhance treatment outcomes, optimize, medication use, promote adherence, and ensure safer self-care practices. As self-medication trends and the role of pharmacists evolves, this review offers a comprehensive resource to equip pharmacists with the latest knowledge and practical tools for optimizing heartburn management and promoting patient safety.
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Open AccessArticle
Validation of the Sensal Health MyAideTM Smart Dock Medication Adherence Device
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David Wallace, Sourab Ganna and Rajender R. Aparasu
Pharmacy 2025, 13(5), 123; https://doi.org/10.3390/pharmacy13050123 - 1 Sep 2025
Abstract
Background: Electronic monitoring adherence devices (EAMDs) are increasingly being utilized in various healthcare settings to track medication adherence. Objective: To determine the accuracy of the Sensal Health MyAide™ Smart Doc in capturing dose removal from the vial, specifically the time of dose removal
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Background: Electronic monitoring adherence devices (EAMDs) are increasingly being utilized in various healthcare settings to track medication adherence. Objective: To determine the accuracy of the Sensal Health MyAide™ Smart Doc in capturing dose removal from the vial, specifically the time of dose removal and the number of pills removed for each actuation of the device. Methods: This validation study compares the device’s recording of dose withdrawals from a prescription vial by simulated patients against reference documentation reported using MS Forms by the participants. Three participants completed a 4-day study consisting of two non-consecutive 1 h sessions per day encompassing six actuations from the prescription vial to be captured by the Sensal Health MyAide™ Smart Dock after their informed consent was obtained. Statistical analysis included percent agreement and Cohen’s kappa assessing agreement between user-reported data and electronic measurement data recorded by the MyAide™ Smart Dock. Outcome measures included confirmation of the specific user, time of dose removal (±1 min), and the number of pills withdrawn. Results: Three subjects were recruited to provide data for a total of 144 actuations. The study found perfect 100% agreement across the number of pills withdrawn and specific users withdrawing the pills and 99% agreement for the time of administration. The Cohen’s kappa values for the outcome measures were 1.00 (95%CI [1.00, 1.00]) for the number of pills dispensed and specific user and 0.993 (95%CI [0.990, 0.996]) for the time of administration. Conclusions: This study found that the Sensal Health MyAide™ Smart Dock can accurately record the time of administration, the number of pills dispensed, and the identity of the user dispensing the pills.
Full article
(This article belongs to the Section Pharmacy Practice and Practice-Based Research)
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Open AccessArticle
Pharmacy Students’ Experience of an Inaugural Lecture on Intercultural Competence
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Atta Abbas Naqvi, Merhawi Samsom, Lucy Watson and Hung Nguyen
Pharmacy 2025, 13(5), 122; https://doi.org/10.3390/pharmacy13050122 - 1 Sep 2025
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Background: Pharmacy schools in the United Kingdom (UK) are required by the regulator to train pharmacy students to be culturally competent. To meet this requirement, the Reading School of Pharmacy (RSoP) incorporated an inaugural, stand-alone, introductory session on intercultural competency. This study aimed
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Background: Pharmacy schools in the United Kingdom (UK) are required by the regulator to train pharmacy students to be culturally competent. To meet this requirement, the Reading School of Pharmacy (RSoP) incorporated an inaugural, stand-alone, introductory session on intercultural competency. This study aimed to gather students’ experiences of the lecture. Methods: A qualitative study documented the experiences of students in Years 2 and 3 of the Master of Pharmacy (MPharm) at the RSoP from 15 September to 31 December 2023. Semi-structured interviews were conducted online via Microsoft Teams®. A demographic form was prepared and sent as an online survey link on the Online Surveys® platform. All eligible students were invited to participate in the study via student mailing lists. An interview guide was prepared. Thematic analysis was conducted to identify key themes related to students’ awareness, the perceived importance of the subject in healthcare, and students’ preferred learning methods. The transcripts were coded, and similar codes were grouped to form sub-themes and themes. The study was approved by a research ethics committee. Results: A total of 11 students attended the interviews. Three major themes emerged: (1) awareness of and reflection on cultural competence, (2) understanding cultural competence and its importance, and (3) student-preferred pedagogy. The students suggested incorporating workshops and simulation-based assessments. Conclusions: MPharm pharmacy students at the RSoP appear to be receptive to new educational interventions aimed at enhancing cultural competence. They prefer practice-based learning and assessment methods when it comes to developing this skill.
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Open AccessArticle
Assessing Pharmacy Costs of Intravenous Push Controlled Substance Waste in Hospital-Based Areas: A Multi-Site Study
by
John Hertig, Les Louden, Blake Shay, Armando Soto, Thi Doan and Zach Gross
Pharmacy 2025, 13(5), 121; https://doi.org/10.3390/pharmacy13050121 - 1 Sep 2025
Abstract
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Intravenous push (IVP) administration of controlled substances in hospital settings presents operational challenges related to medication waste, documentation, and diversion risk. This multi-site observational study aimed to quantify the pharmacy workforce time and associated costs linked to IVP waste management across a 16-hospital
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Intravenous push (IVP) administration of controlled substances in hospital settings presents operational challenges related to medication waste, documentation, and diversion risk. This multi-site observational study aimed to quantify the pharmacy workforce time and associated costs linked to IVP waste management across a 16-hospital health system in Southwest Florida. Data were collected from over 4400 controlled substance transactions involving fentanyl, midazolam, hydromorphone, morphine, ketamine, and lorazepam. Methods included automated transaction analysis, manual chart reviews, and software-based compliance case evaluations. Results indicated patterns of partial dose waste, particularly for midazolam (85.2%) and hydromorphone (78.8%), and identified opportunities where documentation efforts could be further optimized through automation. Manual review of 333 incidents required an average of 6 min and 43 s per case, extrapolating to over 496 h of quarterly pharmacy labor or nearly 1985 h annually. Software-based case reviews added another 32 h per quarter or 130 h annually. Additionally, waste receptacle systems incurred over USD 1.1 million in capital costs and USD 322,500 in annual maintenance, with technician labor contributing further operational burden. These findings underscore the resource demands of IVP waste management and support the need for standardized dosing, enhanced documentation workflows, and pharmacy-led interventions to improve efficiency and reduce diversion risk.
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Open AccessReview
Neuraxial Anesthesia and Cancer Recurrence Following Prostatectomy: Thinking Outside the Box
by
Maria P. Ntalouka, Panagiotis J. Vlachostergios, Metaxia Bareka, Konstantinos Dimitropoulos, Anastasia Michou, Ioannis Zachos, Aikaterini Bouzia, Ecaterina Scarlatescu, Vassilios Tzortzis and Eleni M. Arnaoutoglou
Pharmacy 2025, 13(5), 120; https://doi.org/10.3390/pharmacy13050120 - 1 Sep 2025
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Radical prostatectomy is the standard of care for the treatment of early, clinically localized prostate cancer (PC). In addition to known clinical prognosticators, perioperative conditions and the type of anesthesia may affect clinical outcomes through several mechanisms that favor a tumor-propagating state, including
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Radical prostatectomy is the standard of care for the treatment of early, clinically localized prostate cancer (PC). In addition to known clinical prognosticators, perioperative conditions and the type of anesthesia may affect clinical outcomes through several mechanisms that favor a tumor-propagating state, including activation of the sympathetic system, increased opioid requirements, and inflammation. In this review, we provide an overview of the impact of the perioperative period on PC prognosis and patient outcomes. A non-systematic literature review was conducted to investigate the possible association between neuraxial anesthesia and outcomes after radical prostatectomy (RP) for prostate cancer. The following keywords were used: “cancer recurrence” OR “cancer prognosis” OR “metastasis” AND “neuraxial anesthesia” AND “prostate cancer”. Eligible studies were summarized in the form of a narrative review. In the era of limited use of ERAS protocols, the implementation of neuraxial anesthesia was found to reduce mortality after RP for primary prostate cancer when compared to general anesthesia. Although there was no significant association between anesthetic technique and radiological or biochemical-free survival, regional anesthesia may have an impact on short-term survival in patients with severe comorbidities, involving pulmonary complications and thrombosis. The effect of anesthetic technique on PC patient outcomes remains elusive, although preliminary retrospective evidence suggests a possible positive effect of neuraxial anesthesia on patient outcomes. As the perioperative period is considered a vulnerable timeframe for these patients, the role of the leadership dyad of surgeon and onco-anesthesiologist is crucial.
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Open AccessArticle
Evaluation of a Community Pharmacist-Led Intervention Program for Early Detection of Gastrointestinal Adverse Events of Dipeptidyl Peptidase-4 Inhibitors: A Multicenter, Non-Randomized Comparative Study
by
Ayana Funabashi, Hitoshi Ito, Mamoru Maeda, Yoshitaka Hasegawa, Ryota Tsukioka and Mitsuko Onda
Pharmacy 2025, 13(5), 119; https://doi.org/10.3390/pharmacy13050119 - 28 Aug 2025
Abstract
In this multicenter, nonrandomised comparative study, we evaluated the potential effectiveness of a program to promote the safe use of dipeptidyl peptidase-4 (DPP-4) inhibitors led by community pharmacists. The program facilitated early detection of gastrointestinal adverse events (GIAEs) in patients newly prescribed DPP-4
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In this multicenter, nonrandomised comparative study, we evaluated the potential effectiveness of a program to promote the safe use of dipeptidyl peptidase-4 (DPP-4) inhibitors led by community pharmacists. The program facilitated early detection of gastrointestinal adverse events (GIAEs) in patients newly prescribed DPP-4 inhibitors and facilitated timely communication with physicians. Community pharmacists reviewed patient conditions and provided relevant information to physicians as needed. GIAE monitoring based on the program was conducted in 35 patients at 10 pharmacies in Japan (intervention group) between March and August 2024. The proportion of pharmacist interventions was compared with that in 451 patients from March to August 2023, before program implementation (baseline cohort). The primary outcome, pharmacist intervention rate, was significantly higher in the intervention group (5 out of 35 patients, 14.3%) than in the baseline cohort (0 out of 451 patients, 0.0%) (p < 0.001). GIAEs were identified in 13 out of 35 patients (37.1%) in the intervention group; information for five patients (14.3%) was shared with physicians, resulting in discontinuation of the DPP-4 inhibitor in one patient and addition of supportive therapy in others. Most GIAEs occurred within the first 1–2 weeks of therapy, highlighting the need for early intervention. Thus, proactive involvement of community pharmacists may improve the care process in these cases and contribute to healthcare coordination and diabetes care quality.
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(This article belongs to the Topic Optimization of Drug Utilization and Medication Adherence)
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Ethnography in Primary Health Care: Theoretical–Methodological Reflections on Pharmaceutical Services
by
Samara Jamile Mendes, Silvana Nair Leite, Livia Maria de Souza Gonçalves, Marília Berlofa Visacri and Silvia Storpirtis
Pharmacy 2025, 13(5), 118; https://doi.org/10.3390/pharmacy13050118 - 28 Aug 2025
Abstract
In pharmacy, theoretical and methodological approaches from anthropology and the social sciences have been increasingly used to understand the complexity of health–disease processes and their relationship with medicines and social practices. Ethnography offers a critical and in-depth lens for analyzing phenomena in Primary
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In pharmacy, theoretical and methodological approaches from anthropology and the social sciences have been increasingly used to understand the complexity of health–disease processes and their relationship with medicines and social practices. Ethnography offers a critical and in-depth lens for analyzing phenomena in Primary Health Care (PHC), bridging persistent gaps between theory and method in health research. This article presents the theoretical and methodological trajectory of an ethnographic study on pharmaceutical services in PHC, conducted through participant observation in three Units in São Paulo, totaling 166 h of fieldwork. Data were recorded in field diaries and analyzed using a thematic inductive approach, leading to the development of conceptual categories and an analytical framework. Reflections on the method enabled interpretive analyses based on assumptions that were confronted with national and international trends in pharmacy literature. Constructing the method in a non-isolated, context-sensitive way was essential to understanding how pharmacists actively shape their practices in PHC. The study reinforces the relevance of participant observation as both a methodological and interpretive strategy, revealing that pharmaceutical services are being constructed through culturally situated practices that respond to health needs with the pharmacist’s active involvement.
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Open AccessArticle
Exploring the Perceptions of Undergraduate Pharmacy Students’ Communication Skills to Facilitate Better Professional Decision-Making in the UK
by
Aadesh Dave and Sukvinder Kaur Bhamra
Pharmacy 2025, 13(5), 117; https://doi.org/10.3390/pharmacy13050117 - 28 Aug 2025
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Background: Pharmacy professionals have an important role in delivering patient-centred care, with effective communication skills forming the foundation of interactions with patients. This study aimed to explore how pharmacy students perceived their own communication skills; along with the communication skills education and
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Background: Pharmacy professionals have an important role in delivering patient-centred care, with effective communication skills forming the foundation of interactions with patients. This study aimed to explore how pharmacy students perceived their own communication skills; along with the communication skills education and training experiences in their undergraduate pharmacy degree in the UK. Methods: A 22-item questionnaire was designed and piloted before being distributed online. Snowball sampling was employed to recruit participants undertaking an undergraduate pharmacy degree. Quantitative statistical and qualitative thematic analysis was conducted. Results: A range of pharmacy schools were represented in the data set (n = 10) with 217 responses collected. Participants rated their communication skills highly (53.03%, n = 114), but stated they still required improvement (79.72%, n = 173). A proportion of participants stated that they could appropriately make professional decisions (52.08%, n = 100) and that their communication skills had facilitated their professional decision-making skills (57.89%, n = 110). Effective teaching methods reported included role play with peers (80%, n = 156) and small-group teaching sessions (64.10%, n = 125). Participants felt that interprofessional education and simulated patients could help improve their communication skills further. Conclusions: Communication education is a crucial element in developing future healthcare professionals. Thus, investment in resources is required to facilitate communication skills in the earlier stages of the undergraduate pharmacy degree.
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