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Biomolecules, Volume 15, Issue 1
January 2025 - 152 articles
Cover Story: Extracellular vesicles and tunnelling nanotubes are integral for communication in prostate cancer, but the extent and impact of cargo transfer to other cells is poorly understood. Here, we used live cell imaging to investigate cargo transfer between prostate cancer, immune cells and non-malignant cells. Androgen treatment altered the morphology of prostate cancer cells. Ezrin, an androgen-regulated protein, may play a role in a mechanistic switch between TNTs and EV production to facilitate communication. The specialist cargo we observed being transferred may support cancer growth and progression by sharing energy resources, reprogramming and signalling cascades. This makes these important intercellular communication systems ideal potential targets for therapeutic intervention. View this paper
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Biomolecules - ISSN 2218-273X