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Biomolecules
Volume 13
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10.3390/biom13030428
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Article

Circulating Tumor Cell Detection by Liquid Biopsy during Early-Stage Endometrial Cancer Surgery: A Pilot Study

by
Sarah Francini
1,†,
Martha Duraes
1,*,†,
Gauthier Rathat
1,
Valérie Macioce
2,
Caroline Mollevi
2,
Laurence Pages
2,
Catherine Ferrer
3,
Laure Cayrefourcq
4,5,6,‡ and
Catherine Alix-Panabières
4,5,6,*,‡
1
Department of Gynecological and Breast Surgery, Montpellier University Hospital, 34000 Montpellier, France
2
Clinical Research and Epidemiology Unit, Montpellier University Hospital, 34000 Montpellier, France
3
Department of Gynecological and Breast Surgery, Nimes University Hospital, 30000 Nimes, France
4
Laboratory of Rare Human Circulating Cells, University Medical Center of Montpellier, 34000 Montpellier, France
5
CREEC, MIVEGEC, University of Montpellier, CNRS, IRD, 34000 Montpellier, France
6
European Liquid Biopsy Society (ELBS), 20246 Hamburg, Germany
*
Authors to whom correspondence should be addressed.
†
Co-first authors who contributed equally to the work.
‡
Co-last authors who contributed equally to the work.
Biomolecules 2023, 13(3), 428; https://doi.org/10.3390/biom13030428
Submission received: 20 December 2022 / Revised: 16 February 2023 / Accepted: 21 February 2023 / Published: 24 February 2023
(This article belongs to the Special Issue Molecular and Cell Biology in Endometriosis and Endometrial Cancer)
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Abstract

The recurrence of non-metastatic endometrial carcinoma (EC) (6 to 21%) might be due to disseminated tumor cells. This feasibility study investigated whether circulating tumor cells (CTCs) were detectable in blood samples from the peripheral and ovarian veins of 10 patients undergoing laparoscopic resection of stage I-II EC between July 2019 and September 2021. CTCs were detected using the CellSearch® system (i) preoperatively (T0) in peripheral blood, (ii) after ovary suspensory ligament pediculation in ovarian vein blood (T1), and (iii) before colpotomy in peripheral blood (T2). CTCs were detected only in ovarian vein samples in 8/10 patients. The CTC median number did not differ with patient age (37 (min-max: 0–91) in <70-year-old vs. 11 (0–65) in ≥70 year-old women, p = 0.59), tumor grade (15 (0–72) for grade 1 vs. 15 (0–91) for grade 2, p = 0.97), FIGO stage (72 (27–91) vs. 2 (0–65) vs. 3 (0–6]) for stage IA, B, and II, respectively; p = 0.08), and tumor size (40 (2–72) for size < 30 mm vs. 4 (0–91) for size ≥ 30 mm, p = 0.39). Estrogen receptor-positive CTCs and CTC clusters were identified. The prognostic and therapeutic values of CTCs released during EC surgery need to be determined.
Keywords: endometrial cancer; liquid biopsy; circulating tumor cells; laparoscopy endometrial cancer; liquid biopsy; circulating tumor cells; laparoscopy

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MDPI and ACS Style

Francini, S.; Duraes, M.; Rathat, G.; Macioce, V.; Mollevi, C.; Pages, L.; Ferrer, C.; Cayrefourcq, L.; Alix-Panabières, C. Circulating Tumor Cell Detection by Liquid Biopsy during Early-Stage Endometrial Cancer Surgery: A Pilot Study. Biomolecules 2023, 13, 428. https://doi.org/10.3390/biom13030428

AMA Style

Francini S, Duraes M, Rathat G, Macioce V, Mollevi C, Pages L, Ferrer C, Cayrefourcq L, Alix-Panabières C. Circulating Tumor Cell Detection by Liquid Biopsy during Early-Stage Endometrial Cancer Surgery: A Pilot Study. Biomolecules. 2023; 13(3):428. https://doi.org/10.3390/biom13030428

Chicago/Turabian Style

Francini, Sarah, Martha Duraes, Gauthier Rathat, Valérie Macioce, Caroline Mollevi, Laurence Pages, Catherine Ferrer, Laure Cayrefourcq, and Catherine Alix-Panabières. 2023. "Circulating Tumor Cell Detection by Liquid Biopsy during Early-Stage Endometrial Cancer Surgery: A Pilot Study" Biomolecules 13, no. 3: 428. https://doi.org/10.3390/biom13030428

APA Style

Francini, S., Duraes, M., Rathat, G., Macioce, V., Mollevi, C., Pages, L., Ferrer, C., Cayrefourcq, L., & Alix-Panabières, C. (2023). Circulating Tumor Cell Detection by Liquid Biopsy during Early-Stage Endometrial Cancer Surgery: A Pilot Study. Biomolecules, 13(3), 428. https://doi.org/10.3390/biom13030428

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