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Biomolecules, Volume 10, Issue 12
December 2020 - 112 articles
Cover Story: Cannabinoid receptor interacting protein 1a (CRIP1a) can (left to right): attenuate CB1 receptor-mediated inhibition of adenylyl cyclase, alter the activated Gi subtype, and reduce beta-arrestin binding to the CB1 receptor. CRIP1a expression thereby increases intracellular cAMP production but decreases CB1 receptor internalization and ERK phosphorylation. This suggests that CRIP1a can regulate physiology in healthy tissues, and that genetic or epigenetic changes can be associated with disease states. Physiological and pathophysiological implications of CRIP1a expression have been reported in embryonic development, seizures, schizophrenia, visual and auditory sensory systems, and cancer. View this paper
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Biomolecules - ISSN 2218-273X