Next Article in Journal
Significance of Artificial Intelligence in the Study of Virus–Host Cell Interactions
Previous Article in Journal
Decoding the Role of O-GlcNAcylation in Hepatocellular Carcinoma
Previous Article in Special Issue
Physical Interventions Restore Physical Frailty and the Expression of CXCL-10 and IL-1β Inflammatory Biomarkers in Old Individuals and Mice
 
 
Search for Articles:
Title / Keyword
Author / Affiliation / Email
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
 
Journals
Biomolecules
Volume 14
Issue 8
10.3390/biom14080909
biomolecules-logo
Submit to this Journal Review for this Journal Propose a Special Issue
► Article Menu

Article Menu

share Share announcement Help format_quote Cite question_answer Discuss in SciProfiles
first_page
settings
Order Article Reprints
Font Type:
Arial Georgia Verdana
Font Size:
Aa Aa Aa
Line Spacing:
Column Width:
Background:
Article

Markers of Mitochondrial Function and DNA Repair Associated with Physical Function in Centenarians

by
Ines Sanchez-Roman
1,2,*,†,
Beatriz Ferrando
1,2,3,
Camilla Myrup Holst
1,2,
Jonas Mengel-From
2,4,
Signe Hoei Rasmussen
2,4,5,
Mikael Thinggaard
2,4,
Vilhelm A. Bohr
6,
Kaare Christensen
2,4 and
Tinna Stevnsner
1,2,*
1
Department of Molecular Biology and Genetics, Aarhus University, 8000 Aarhus, Denmark
2
Danish Aging Research Center, Department of Public Health, University of Southern Denmark, 5230 Odense, Denmark
3
Facultad de Humanidades y Ciencias Sociales, Universidad Isabel I, 09003 Burgos, Spain
4
Epidemiology, Biostatistics and Biodemography, University of Southern Denmark, 5230 Odense, Denmark
5
Geriatric Research Unit, Department of Clinical Research, University of Southern Denmark, 5230 Odense, Denmark
6
Department of Cellular and Molecular Medicine, University of Copenhagen, 2200 Copenhagen, Denmark
*
Authors to whom correspondence should be addressed.
†
Current address: Department of Genetics, Physiology and Microbiology, Faculty of Biological Sciences, Complutense University, 28040 Madrid, Spain.
Biomolecules 2024, 14(8), 909; https://doi.org/10.3390/biom14080909
Submission received: 13 June 2024 / Revised: 16 July 2024 / Accepted: 22 July 2024 / Published: 26 July 2024
(This article belongs to the Special Issue Mechanisms and Novel Biomarkers Underlying Aging and Longevity)
Browse Figures
Versions Notes

Abstract

Mitochondrial dysfunction and genomic instability are key hallmarks of aging. The aim of this study was to evaluate whether maintenance of physical capacities at very old age is associated with key hallmarks of aging. To investigate this, we measured mitochondrial bioenergetics, mitochondrial DNA (mtDNA) copy number and DNA repair capacity in peripheral blood mononuclear cells from centenarians. In addition, circulating levels of NAD+/NADH, brain-derived neurotrophic factor (BDNF) and carbonylated proteins were measured in plasma and these parameters were correlated to physical capacities. Centenarians without physical disabilities had lower mitochondrial respiration values including ATP production, reserve capacity, maximal respiration and non-mitochondrial oxygen-consumption rate and had higher mtDNA copy number than centenarians with moderate and severe disabilities (p < 0.05). In centenarian females, grip strength had a positive association with mtDNA copy number (p < 0.05), and a borderline positive trend for activity of the central DNA repair enzyme, APE 1 (p = 0.075), while a negative trend was found with circulating protein carbonylation (p = 0.07) in the entire cohort. Lastly, a trend was observed for a negative association between BDNF and activity of daily living disability score (p = 0.06). Our results suggest that mechanisms involved in maintaining mitochondrial function and genomic stability may be associated with maintenance of physical function in centenarians.
Keywords: centenarians; mitochondria; DNA repair; grip strength; physical function centenarians; mitochondria; DNA repair; grip strength; physical function

Share and Cite

MDPI and ACS Style

Sanchez-Roman, I.; Ferrando, B.; Myrup Holst, C.; Mengel-From, J.; Hoei Rasmussen, S.; Thinggaard, M.; Bohr, V.A.; Christensen, K.; Stevnsner, T. Markers of Mitochondrial Function and DNA Repair Associated with Physical Function in Centenarians. Biomolecules 2024, 14, 909. https://doi.org/10.3390/biom14080909

AMA Style

Sanchez-Roman I, Ferrando B, Myrup Holst C, Mengel-From J, Hoei Rasmussen S, Thinggaard M, Bohr VA, Christensen K, Stevnsner T. Markers of Mitochondrial Function and DNA Repair Associated with Physical Function in Centenarians. Biomolecules. 2024; 14(8):909. https://doi.org/10.3390/biom14080909

Chicago/Turabian Style

Sanchez-Roman, Ines, Beatriz Ferrando, Camilla Myrup Holst, Jonas Mengel-From, Signe Hoei Rasmussen, Mikael Thinggaard, Vilhelm A. Bohr, Kaare Christensen, and Tinna Stevnsner. 2024. "Markers of Mitochondrial Function and DNA Repair Associated with Physical Function in Centenarians" Biomolecules 14, no. 8: 909. https://doi.org/10.3390/biom14080909

APA Style

Sanchez-Roman, I., Ferrando, B., Myrup Holst, C., Mengel-From, J., Hoei Rasmussen, S., Thinggaard, M., Bohr, V. A., Christensen, K., & Stevnsner, T. (2024). Markers of Mitochondrial Function and DNA Repair Associated with Physical Function in Centenarians. Biomolecules, 14(8), 909. https://doi.org/10.3390/biom14080909

Note that from the first issue of 2016, this journal uses article numbers instead of page numbers. See further details here.

Article Metrics

Back to TopTop