HPLC Analysis and Cytotoxicity of n-Butanol Extract from Glyphaea brevis Roots Against C6 Glioma Cells

Koffi Marcel KONAN; Janat Akhanovna MAMYRBEKOVA-BEKRO; Norbert BAKALARA; David VIRIEUX; Jean-Luc PIRAT; Yves-Alain BEKRO

doi:10.3797/scipharm.1307-08

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Short Communication

19 November 2013

HPLC Analysis and Cytotoxicity of n-Butanol Extract from Glyphaea brevis Roots Against C6 Glioma Cells

and

Laboratoire de Chimie Bioorganique et de Substances Naturelles (LCBOSN), UFR-SFA, Université Nangui Abrogoua, 02 BP 801 Abidjan 02, Côte d’Ivoire

UMR 5253, ICG Montpellier, Equipe AM2N, ENSCM, 8, rue de l'Ecole Normale, 34296 Montpellier cedex 5, France

INSERM U-1051, Institut des Neurosciences de Montpellier, 80 rue Augustin Fliche 34091 Montpellier, France

Author to whom correspondence should be addressed.

Sci. Pharm.2014, 82(1), 171-176;https://doi.org/10.3797/scipharm.1307-08

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Abstract

The n-butanol extract of the roots of Glyphaea brevis was analysed. HPLC analysis suggested the presence of phenolic compounds like protocatechuic acid (PCA). The extract showed moderate cytotoxic activity against C6 glioma cells (EC50 > 1 mg/ml).

Keywords:

Glyphaea brevis; HPLC; Protocatechuic acid; Cytotoxicity; C6 Cells

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