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Scientia Pharmaceutica, Volume 79, Issue 1

March 2011 - 16 articles

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Articles (16)

  • Article
  • Open Access
11 Citations
1,894 Views
8 Pages

Antitrypanosomal and Cytotoxic Activities of 22-Hydroxyclerosterol, a New Sterol from Allexis cauliflora (Violaceae)

  • Yves Oscar D. NGANSO,
  • Igor Eric W. NGANTCHOU,
  • Ernestine NKWENOUA,
  • Barthelemy NYASSE,
  • Colette DENIER,
  • Véronique HANNERT and
  • Bernd SCHNEIDER

7 February 2011

In the search for new antiparasitic natural compounds from the medicinal plants from Cameroon, the new 22-hydroxyclerosterol, established as such on the basis of detailed chemical and spectroscopic analysis, was isolated from the hexane extract of th...

  • Short Communication
  • Open Access
5 Citations
1,467 Views
5 Pages

Phenolics from Rhagadiolus stellatus (Asteraceae, Cichorieae)

  • Romana KRIMPLSTÄTTER,
  • Benjamin MA,
  • Renate SPITALER,
  • Ernst ELLMERER and
  • Christian ZIDORN

7 February 2011

Rhagadiolus stellatus Gaertn., a Mediterranean member of the Cichorieae tribe of the Asteraceae family used as a food plant, was analyzed for its spectrum of phenolic compounds. Kaempferol 3-O-β-glucoside 1, kaempferol 3-O-β- rutinoside (nicotiflorin...

  • Article
  • Open Access
12 Citations
2,064 Views
10 Pages

Stability Indicating LC-Method for Estimation of Paracetamol and Lornoxicam in Combined Dosage Form

  • Dimal A. SHAH,
  • Neel J. PATEL,
  • Sunil L. BALDANIA,
  • Usman K. CHHALOTIYA and
  • Kashyap K. BHATT

20 January 2011

A simple, specific and stability indicating reversed phase high performance liquid chromatographic method was developed for the simultaneous determination of paracetamol and lornoxicam in tablet dosage form. A Brownlee C-18, 5 μm column having 250×4....

  • Article
  • Open Access
22 Citations
2,405 Views
15 Pages

16 January 2011

The present work reports a stability indicating reversed phase ultra performance liquid chromatography (RP-UPLC) method for the quantitative determination of quetiapine in pharmaceutical dosage form. The chromatographic separation is performed on an...

  • Article
  • Open Access
17 Citations
3,412 Views
12 Pages

10 January 2011

A novel stability-indicating RP-HPLC assay method was developed and validated for quantitative determination of rebamipide in bulk and tablet dosage form. Rebamipide (drug and drug product) solutions were exposed to acid and alkali hydrolysis, therma...

  • Article
  • Open Access
44 Citations
3,805 Views
16 Pages

4 January 2011

A simple, precise and rapid stability-indicating ultra-performance liquid chromatography (UPLC) method is developed for the simultaneous quantitative determination of Telmisartan, Amlodipine besylate and Hydrochlorothiazide from their innovative poly...

  • Review
  • Open Access
73 Citations
3,521 Views
20 Pages

31 December 2010

Phytoestrogens are a family of diverse polyphenolic compounds derived from nature plant that structurally or functionally mimic circulating estrogen in the mammalian reproductive system. They induce estrogenic and anti-estrogenic effects in the brain...

  • Article
  • Open Access
10 Citations
1,790 Views
10 Pages

New Substituted Isocoumarins and Dihydroisocoumarins and their Cytotoxic Activities

  • Veronika Hampl,
  • Isolde Wetzel,
  • Franz Bracher and
  • Jürgen KRAUSS

18 December 2010

New isocoumarins were prepared in an efficient way from 2-iodobenzoic acid derivatives and hept-1-yne in a Sonogashira reaction, followed by spontaneous cyclization. Catalytic hydrogenation gave the corresponding dihydroisocoumarins. A 4-chloroisocou...

  • Article
  • Open Access
9 Citations
1,608 Views
10 Pages

18 December 2010

A novel approach to 3-oxo-γ-carbolines was worked out starting from methyl indol-2-ylacetate via a gramine derivative. After quaternization, ammonia and 4-methoxybenzylamine could be inserted giving appropriate 3-oxo-γ-carbolines. Condensation with 2...

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Sci. Pharm. - ISSN 2218-0532