Next Article in Journal
Antiproliferative Activity of Plant Extracts Used Against Cancer in Traditional Medicine
Previous Article in Journal
Development and Validation of a Stability Indicating RP-UPLC Method for Determination of Quetiapine in Pharmaceutical Dosage Form
 
 
Search for Articles:
Title / Keyword
Author / Affiliation / Email
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
 
Journals
Sci. Pharm.
Volume 79
Issue 1
10.3797/scipharm.1012-03
scipharm-logo
Submit to this Journal Review for this Journal Propose a Special Issue
► Article Menu

Article Menu

share Share announcement Help format_quote Cite question_answer Discuss in SciProfiles thumb_up
...
Endorse textsms
...
Comment
Scientia Pharmaceutica is published by MDPI from Volume 84 Issue 3 (2016). Previous articles were published by another publisher in Open Access under a CC-BY (or CC-BY-NC-ND) licence, and they are hosted by MDPI on mdpi.com as a courtesy and upon agreement with Austrian Pharmaceutical Society (Österreichische Pharmazeutische Gesellschaft, ÖPhG).
first_page
settings
Order Article Reprints
Font Type:
Arial Georgia Verdana
Font Size:
Aa Aa Aa
Line Spacing:
Column Width:
Background:
Article

Stability Indicating LC-Method for Estimation of Paracetamol and Lornoxicam in Combined Dosage Form

by
Dimal A. SHAH
1,*,
Neel J. PATEL
2,
Sunil L. BALDANIA
1,
Usman K. CHHALOTIYA
1 and
Kashyap K. BHATT
1
1
Indukaka Ipcowala College of Pharmacy, Beyond GIDC, P.B. No. 53, Vitthal Udyognagar-388 121, Gujarat, India
2
A. R. College of Pharmacy, P. Box No. 19, Vallabh Vidyanagar-388 120, Gujarat, India
*
Author to whom correspondence should be addressed.
Sci. Pharm. 2011, 79(1), 113-122; https://doi.org/10.3797/scipharm.1012-03
Submission received: 4 December 2010 / Accepted: 20 January 2011 / Published: 20 January 2011
Versions Notes

Abstract

A simple, specific and stability indicating reversed phase high performance liquid chromatographic method was developed for the simultaneous determination of paracetamol and lornoxicam in tablet dosage form. A Brownlee C-18, 5 μm column having 250×4.6 mm i.d. in isocratic mode, with mobile phase containing 0.05 M potassium dihydrogen phosphate:methanol (40:60, v/v) was used. The flow rate was 1.0 ml/min and effluents were monitored at 266 nm. The retention times of paracetamol and lornoxicam were 2.7 min and 5.1 min, respectively. The linearity for paracetamol and lornoxicam were in the range of 5–200 μg/ml and 0.08–20 μg/ml, respectively. Paracetamol and lornoxicam stock solutions were subjected to acid and alkali hydrolysis, chemical oxidation and dry heat degradation. The proposed method was validated and successfully applied to the estimation of paracetamol and lornoxicam in combined tablet dosage form.
Keywords: RP-HPLC; Validation; Simultaneous determination; Degradation RP-HPLC; Validation; Simultaneous determination; Degradation

Share and Cite

MDPI and ACS Style

SHAH, D.A.; PATEL, N.J.; BALDANIA, S.L.; CHHALOTIYA, U.K.; BHATT, K.K. Stability Indicating LC-Method for Estimation of Paracetamol and Lornoxicam in Combined Dosage Form. Sci. Pharm. 2011, 79, 113-122. https://doi.org/10.3797/scipharm.1012-03

AMA Style

SHAH DA, PATEL NJ, BALDANIA SL, CHHALOTIYA UK, BHATT KK. Stability Indicating LC-Method for Estimation of Paracetamol and Lornoxicam in Combined Dosage Form. Scientia Pharmaceutica. 2011; 79(1):113-122. https://doi.org/10.3797/scipharm.1012-03

Chicago/Turabian Style

SHAH, Dimal A., Neel J. PATEL, Sunil L. BALDANIA, Usman K. CHHALOTIYA, and Kashyap K. BHATT. 2011. "Stability Indicating LC-Method for Estimation of Paracetamol and Lornoxicam in Combined Dosage Form" Scientia Pharmaceutica 79, no. 1: 113-122. https://doi.org/10.3797/scipharm.1012-03

APA Style

SHAH, D. A., PATEL, N. J., BALDANIA, S. L., CHHALOTIYA, U. K., & BHATT, K. K. (2011). Stability Indicating LC-Method for Estimation of Paracetamol and Lornoxicam in Combined Dosage Form. Scientia Pharmaceutica, 79(1), 113-122. https://doi.org/10.3797/scipharm.1012-03

Article Metrics

Back to TopTop