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New Substituted Isocoumarins and Dihydroisocoumarins and their Cytotoxic Activities
Department of Pharmacy – Center for Drug Research, Ludwig-Maximilians University, Butenandtstr. 5–13, D-81377 Munich, Germany
Author to whom correspondence should be addressed.
Received: 30 November 2010 / Accepted: 17 December 2010 / Published: 18 December 2010
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Abstract New isocoumarins were prepared in an efficient way from 2-iodobenzoic acid derivatives and hept-1-yne in a Sonogashira reaction, followed by spontaneous cyclization. Catalytic hydrogenation gave the corresponding dihydroisocoumarins. A 4-chloroisocoumarin was prepared on an alternative pathway. Some of the new compounds showed moderate cytotoxic activities against a human leukemia cell line (HL 60).
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Hampl, V.; Wetzel, I.; Bracher, F.; KRAUSS, J. New Substituted Isocoumarins and Dihydroisocoumarins and their Cytotoxic Activities. Sci. Pharm. 2011, 79, 21-30.
Hampl V, Wetzel I, Bracher F, KRAUSS J. New Substituted Isocoumarins and Dihydroisocoumarins and their Cytotoxic Activities. Scientia Pharmaceutica. 2011; 79(1):21-30.
Hampl, Veronika; Wetzel, Isolde; Bracher, Franz; KRAUSS, Jürgen. 2011. "New Substituted Isocoumarins and Dihydroisocoumarins and their Cytotoxic Activities." Sci. Pharm. 79, no. 1: 21-30.
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