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Sci. Pharm.
Volume 79
Issue 1
10.3797/scipharm.1011-10
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Scientia Pharmaceutica is published by MDPI from Volume 84 Issue 3 (2016). Previous articles were published by another publisher in Open Access under a CC-BY (or CC-BY-NC-ND) licence, and they are hosted by MDPI on mdpi.com as a courtesy and upon agreement with Austrian Pharmaceutical Society (Österreichische Pharmazeutische Gesellschaft, ÖPhG).
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Article

New Substituted Isocoumarins and Dihydroisocoumarins and their Cytotoxic Activities

by
Veronika Hampl
,
Isolde Wetzel
,
Franz Bracher
* and
Jürgen KRAUSS
Department of Pharmacy – Center for Drug Research, Ludwig-Maximilians University, Butenandtstr. 5–13, D-81377 Munich, Germany
*
Author to whom correspondence should be addressed.
Sci. Pharm. 2011, 79(1), 21-30; https://doi.org/10.3797/scipharm.1011-10
Submission received: 30 November 2010 / Accepted: 17 December 2010 / Published: 18 December 2010
Versions Notes

Abstract

New isocoumarins were prepared in an efficient way from 2-iodobenzoic acid derivatives and hept-1-yne in a Sonogashira reaction, followed by spontaneous cyclization. Catalytic hydrogenation gave the corresponding dihydroisocoumarins. A 4-chloroisocoumarin was prepared on an alternative pathway. Some of the new compounds showed moderate cytotoxic activities against a human leukemia cell line (HL 60).
Keywords: Isocoumarins; Dihydroisocoumarins; Sonogashira reaction; Cyclization; Cytotoxicity Isocoumarins; Dihydroisocoumarins; Sonogashira reaction; Cyclization; Cytotoxicity

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MDPI and ACS Style

Hampl, V.; Wetzel, I.; Bracher, F.; KRAUSS, J. New Substituted Isocoumarins and Dihydroisocoumarins and their Cytotoxic Activities. Sci. Pharm. 2011, 79, 21-30. https://doi.org/10.3797/scipharm.1011-10

AMA Style

Hampl V, Wetzel I, Bracher F, KRAUSS J. New Substituted Isocoumarins and Dihydroisocoumarins and their Cytotoxic Activities. Scientia Pharmaceutica. 2011; 79(1):21-30. https://doi.org/10.3797/scipharm.1011-10

Chicago/Turabian Style

Hampl, Veronika, Isolde Wetzel, Franz Bracher, and Jürgen KRAUSS. 2011. "New Substituted Isocoumarins and Dihydroisocoumarins and their Cytotoxic Activities" Scientia Pharmaceutica 79, no. 1: 21-30. https://doi.org/10.3797/scipharm.1011-10

APA Style

Hampl, V., Wetzel, I., Bracher, F., & KRAUSS, J. (2011). New Substituted Isocoumarins and Dihydroisocoumarins and their Cytotoxic Activities. Scientia Pharmaceutica, 79(1), 21-30. https://doi.org/10.3797/scipharm.1011-10

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