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Volume 79
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Article

The Gramine Route to Pyrido[4,3-b]indol-3-ones – Identification of a New Cytotoxic Lead

by
Uwe WOLLEIN
and
Franz BRACHER
*
Department of Pharmacy – Center for Drug Research, Ludwig-Maximilians University, Butenandtstr. 5–13, 81377 Munich, Germany
*
Author to whom correspondence should be addressed.
Sci. Pharm. 2011, 79(1), 59-68; https://doi.org/10.3797/scipharm.1011-11
Submission received: 30 November 2010 / Accepted: 17 December 2010 / Published: 18 December 2010
Versions Notes

Abstract

A novel approach to 3-oxo-γ-carbolines was worked out starting from methyl indol-2-ylacetate via a gramine derivative. After quaternization, ammonia and 4-methoxybenzylamine could be inserted giving appropriate 3-oxo-γ-carbolines. Condensation with 2-chlorobenzaldehyde under microwave irradiation gave a 4-(2-chlorobenzyl)-3-oxo-γ-carboline. N-methylation lead to a product with very promising antifungal and cytotoxic activities.
Keywords: gamma-Carboline; Gramine; Lactam; Cytotoxic activity; Antifungal activity gamma-Carboline; Gramine; Lactam; Cytotoxic activity; Antifungal activity

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MDPI and ACS Style

WOLLEIN, U.; BRACHER, F. The Gramine Route to Pyrido[4,3-b]indol-3-ones – Identification of a New Cytotoxic Lead. Sci. Pharm. 2011, 79, 59-68. https://doi.org/10.3797/scipharm.1011-11

AMA Style

WOLLEIN U, BRACHER F. The Gramine Route to Pyrido[4,3-b]indol-3-ones – Identification of a New Cytotoxic Lead. Scientia Pharmaceutica. 2011; 79(1):59-68. https://doi.org/10.3797/scipharm.1011-11

Chicago/Turabian Style

WOLLEIN, Uwe, and Franz BRACHER. 2011. "The Gramine Route to Pyrido[4,3-b]indol-3-ones – Identification of a New Cytotoxic Lead" Scientia Pharmaceutica 79, no. 1: 59-68. https://doi.org/10.3797/scipharm.1011-11

APA Style

WOLLEIN, U., & BRACHER, F. (2011). The Gramine Route to Pyrido[4,3-b]indol-3-ones – Identification of a New Cytotoxic Lead. Scientia Pharmaceutica, 79(1), 59-68. https://doi.org/10.3797/scipharm.1011-11

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