The Gramine Route to Pyrido[4,3-b]indol-3-ones – Identification of a New Cytotoxic Lead
Department of Pharmacy – Center for Drug Research, Ludwig-Maximilians University, Butenandtstr. 5–13, 81377 Munich, Germany
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Author to whom correspondence should be addressed.
Sci. Pharm. 2011, 79(1), 59-68; https://doi.org/10.3797/scipharm.1011-11
Submission received: 30 November 2010
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Accepted: 17 December 2010
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Published: 18 December 2010
Abstract
A novel approach to 3-oxo-γ-carbolines was worked out starting from methyl indol-2-ylacetate via a gramine derivative. After quaternization, ammonia and 4-methoxybenzylamine could be inserted giving appropriate 3-oxo-γ-carbolines. Condensation with 2-chlorobenzaldehyde under microwave irradiation gave a 4-(2-chlorobenzyl)-3-oxo-γ-carboline. N-methylation lead to a product with very promising antifungal and cytotoxic activities.
Keywords:
gamma-Carboline; Gramine; Lactam; Cytotoxic activity; Antifungal activity
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MDPI and ACS Style
WOLLEIN, U.; BRACHER, F. The Gramine Route to Pyrido[4,3-b]indol-3-ones – Identification of a New Cytotoxic Lead. Sci. Pharm. 2011, 79, 59-68. https://doi.org/10.3797/scipharm.1011-11
AMA Style
WOLLEIN U, BRACHER F. The Gramine Route to Pyrido[4,3-b]indol-3-ones – Identification of a New Cytotoxic Lead. Scientia Pharmaceutica. 2011; 79(1):59-68. https://doi.org/10.3797/scipharm.1011-11
Chicago/Turabian StyleWOLLEIN, Uwe, and Franz BRACHER. 2011. "The Gramine Route to Pyrido[4,3-b]indol-3-ones – Identification of a New Cytotoxic Lead" Scientia Pharmaceutica 79, no. 1: 59-68. https://doi.org/10.3797/scipharm.1011-11
