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Volume 78
Issue 4
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Article

New 4-Thiazolidinones of Nicotinic Acid with 2-Amino-6-methylbenzothiazole and their Biological Activity

by
Navin B. PATEL
* and
Faiyazalam M. SHAIKH
Department of Chemistry, Veer Narmad South Gujarat University, Surat 395007, Gujarat, India
*
Author to whom correspondence should be addressed.
Sci. Pharm. 2010, 78(4), 753-766; https://doi.org/10.3797/scipharm.1009-15
Submission received: 26 September 2010 / Accepted: 24 October 2010 / Published: 24 October 2010
Versions Notes

Abstract

The title compounds 6a–j, 2-[(6-methyl-1,3-benzothiazol-2-yl)amino]-N- [2-(substituted phenyl/furan-2-yl)-4-oxo-1,3-thiazolidin-3-yl]nicotinamides, were prepared from 2-chloropyridine-3-carboxylic acid (1) and 2-amino-6-methylbenzothiazole (2) by known methods. All the compounds have been established by IR, 1H NMR, 13C NMR and elemental analyses. The in vitro antimicrobial screening of the compounds were carried out against two Gram positive (S. aureus, S. pyogenes), two Gram negative (E. coli, P. aeruginosa) bacteria and three fungal species (C. albicans, A. niger, A. clavatus) using the broth microdilution method. Some of the compounds are comparable with standard drugs.
Keywords: Antimicrobial activity; Schiff bases; 4-Thiazolidinones; Nicotinic acid Antimicrobial activity; Schiff bases; 4-Thiazolidinones; Nicotinic acid

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MDPI and ACS Style

PATEL, N.B.; SHAIKH, F.M. New 4-Thiazolidinones of Nicotinic Acid with 2-Amino-6-methylbenzothiazole and their Biological Activity. Sci. Pharm. 2010, 78, 753-766. https://doi.org/10.3797/scipharm.1009-15

AMA Style

PATEL NB, SHAIKH FM. New 4-Thiazolidinones of Nicotinic Acid with 2-Amino-6-methylbenzothiazole and their Biological Activity. Scientia Pharmaceutica. 2010; 78(4):753-766. https://doi.org/10.3797/scipharm.1009-15

Chicago/Turabian Style

PATEL, Navin B., and Faiyazalam M. SHAIKH. 2010. "New 4-Thiazolidinones of Nicotinic Acid with 2-Amino-6-methylbenzothiazole and their Biological Activity" Scientia Pharmaceutica 78, no. 4: 753-766. https://doi.org/10.3797/scipharm.1009-15

APA Style

PATEL, N. B., & SHAIKH, F. M. (2010). New 4-Thiazolidinones of Nicotinic Acid with 2-Amino-6-methylbenzothiazole and their Biological Activity. Scientia Pharmaceutica, 78(4), 753-766. https://doi.org/10.3797/scipharm.1009-15

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