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Sci. Pharm. 2016, 84(4), 625-633;

Effect of Aromatic Substitution of Curcumin Nanoformulations on Their Stability

Department of Pharmaceutical Sciences, Faculty of Pharmacy, Chiang Mai University, Suthep Road, Chiang Mai 50200, Thailand
Author to whom correspondence should be addressed.
Academic Editor: Franz Gabor
Received: 22 February 2016 / Accepted: 31 March 2016 / Published: 19 April 2016
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Curcumin, a poorly water-soluble bioactive compound, was successfully loaded into three different aromatic contents of hydroxypropylmethacrylamide (HPMA)-based polymeric micelles in order to develop water-soluble curcumin nanoformulations (Cur-Nano). The stability study of Cur-Nano was done by keeping the formulations at 4, 30, and 40 °C for 90 days. The physical appearance, curcumin remaining, and particle size of Cur-Nano were examined by visual inspection, high-performance liquid chromatography, and dynamic light scattering, respectively. After the storage period, the Cur-Nano composed of 100% aromatic-substituted polymer exhibited the highest stability of curcumin (80% of curcumin remaining) with a similar particle size as measured on the first day (50–60 nm) in all storage conditions. Curcumin in Cur-Nano composed of 25% and 0% aromatic-substituted polymer was significantly less stable accordingly. The results suggested that aromatic substitution to HPMA-based polymeric micelles can significantly enhance the stability of the loaded curcumin, considerably due to the π-π stacking interactions between the aromatic groups of curcumin and the polymer. It is concluded that curcumin-loaded polymeric micelles with high substituted aromatic content can be promising candidates with good storage stability for further clinical evaluations. View Full-Text
Keywords: curcumin; stability; polymeric micelles; nanoformulations curcumin; stability; polymeric micelles; nanoformulations

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Okonogi, S.; Naksuriya, O.; Charumanee, S.; Sirithunyalug, J. Effect of Aromatic Substitution of Curcumin Nanoformulations on Their Stability. Sci. Pharm. 2016, 84, 625-633.

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