Experimental and Mathematical Analysis of Hepatic Uptake
1
School of Engineering, University of Warwick, Coventry, CV4 7AL, United Kingdom
2
Departments of Pharmacy and Pharmacology, University of Bath, Bath, United Kingdom
3
DMPK Department, Astrazeneca, Alderley Park, Macclesfield, United Kingdom
*
Author to whom correspondence should be addressed.
Sci. Pharm. 2010, 78(3), 696; https://doi.org/10.3797/scipharm.cespt.8.PPAT07
Submission received: 12 July 2010
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Accepted: 12 July 2010
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Published: 12 July 2010
Abstract
Introduction: To investigate the nonlinear kinetics of in vitro hepatic uptake the OATP substrate, Pitivastatin, was used as a probe. Experiments were conducted using freshly isolated rat hepatocytes, utilising the ‘oil spin’ methodology described by Hassen et al [1]. [...]
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MDPI and ACS Style
GRANDJEAN, T.; LENCH, A.; YATES, J.W.T.; CHAPPELL, M.J.; O‘DONNELL, C.J. Experimental and Mathematical Analysis of Hepatic Uptake. Sci. Pharm. 2010, 78, 696. https://doi.org/10.3797/scipharm.cespt.8.PPAT07
AMA Style
GRANDJEAN T, LENCH A, YATES JWT, CHAPPELL MJ, O‘DONNELL CJ. Experimental and Mathematical Analysis of Hepatic Uptake. Scientia Pharmaceutica. 2010; 78(3):696. https://doi.org/10.3797/scipharm.cespt.8.PPAT07
Chicago/Turabian StyleGRANDJEAN, T., A. LENCH, J. W. T. YATES, M. J. CHAPPELL, and C. J. O‘DONNELL. 2010. "Experimental and Mathematical Analysis of Hepatic Uptake" Scientia Pharmaceutica 78, no. 3: 696. https://doi.org/10.3797/scipharm.cespt.8.PPAT07
