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  • Scientia Pharmaceutica is published by MDPI from Volume 84 Issue 3 (2016). Previous articles were published by another publisher in Open Access under a CC-BY (or CC-BY-NC-ND) licence, and they are hosted by MDPI on mdpi.com as a courtesy and upon agreement with Austrian Pharmaceutical Society (Österreichische Pharmazeutische Gesellschaft, ÖPhG).

Scientia Pharmaceutica, Volume 77, Issue 1

March 2009 - 14 articles

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Articles (14)

  • Article
  • Open Access
7 Citations
1,489 Views
9 Pages

17 February 2009

Three dehydrogenases – (R)-alcohol dehydrogenase from L. kefir, (S)-aromatic alcohol dehydrogenase from T. sp. and (S)-alcohol dehydrogenase from T. brockii – were tested for the preparation of enantiopure hydroxyl metabolites of pentoxifylline (PTX)...

  • Article
  • Open Access
18 Citations
1,829 Views
7 Pages

5 February 2009

The marine benzo[c][2,7]naphthyridine alkaloid subarine is prepared in 4 steps, starting from commercially available 1,10-phenanthroline, via oxidative cleavage to the bipyridine-dicarboxylate, conversion to the mono(2-iodoanilide), and radical cycli...

  • Article
  • Open Access
1 Citations
1,535 Views
11 Pages

Isolation and Characterization of an Impurity Obtained During the Synthesis of the Antibiotic Drug Sparfloxacin

  • Nirmala MUNIGELA,
  • Moses BABU J.,
  • Anjaneyulu YERRAMILLI,
  • Peddy VISHWESHWAR,
  • Ganesh YADDANAPUDI SESHA SIVA YADDANAPUDI SESHA SIVA and
  • Narayana Murthy VALAVALA

5 February 2009

During the synthesis of Sparfloxacin, a fluoroquinolone antibiotic drug, an unknown impurity (SF5-IMP) was identified in the fifth stage of the synthetic process. The impurity has been isolated from the mother liquor of intermediate SF5. The mother l...

  • Article
  • Open Access
61 Citations
3,807 Views
11 Pages

Antioxidative and Antiinflammatory Activities of the Chloroform Extract of Ganoderma lucidum Found in South India

  • Soniamol JOSEPH,
  • Baby SABULAL,
  • Varughese GEORGE,
  • Thozhuthumparambal P. SMINA and
  • Kainoor K. JANARDHANAN

30 January 2009

Antioxidative and anti-inflammatory activities of Ganoderma lucidum (Curt.: Fr.) P. Karst. (Aphyllophoromycetideae) from tropical South India were investigated. The chloroform extract of the mushroom showed marked free radical scavenging activities....

  • Article
  • Open Access
3 Citations
1,342 Views
13 Pages

Insight into the Structural Requirement of 2-Alkyl-4-(biphenylmethoxy)quinolines as Nonpeptide Angiotensin II Receptor Antagonists: A QSAR Approach

  • Vivek K. VYAS,
  • Anurekha JAIN,
  • Suresh C. MAHAJAN,
  • Radheshyam PATIDAR,
  • Sunil MISTRY and
  • Subhash C. CHATURVEDI

14 January 2009

In the current study a quantitative structure activity relationship approach using sequential multiple linear regression analysis was applied to a series of 2-alkyl- 4-(biphenylylmethoxy)quinolines as angiotensin II (Ang II) receptor antagonists by u...

  • Article
  • Open Access
3 Citations
1,991 Views
10 Pages

9 January 2009

The freezing process as well as cryostorage may induce molecular and cellular changes due to osmotic stress. Currently, standard protocols for cryopreservation of mammalian cells recommend slow freezing and rapid thawing to avoid intracellular ice cr...

  • Article
  • Open Access
19 Citations
2,286 Views
9 Pages

Biotransformation of Artemisinin Mediated through Fungal Strains for Obtaining Derivatives with Novel Activities

  • Suchita SRIVASTAVA,
  • Suaib LUQMAN,
  • Atiya FATIMA,
  • Mahendra P. DAROKAR,
  • Arvind S. NEGI,
  • J. K. KUMAR,
  • K. SHANKER,
  • Chandan S. CHANOTIYA,
  • Sudeep TANDON and
  • Suman P. S. KHANUJA

8 January 2009

Artemisinin, a sesquiterpene lactone, is the active antimalarial constituent of Artemisia annua. Several fungal strains Saccharomyces cerevisiae, Aspergillus flavus, Aspergillus niger and Picchia pastoris were used to biotransform artemisinin. Among...

  • Article
  • Open Access
24 Citations
3,925 Views
8 Pages

23 December 2008

Plantago major has been used in traditional medicine for the treatment of various diseases. In order to evaluate the quality of P. major, a simple, rapid and accurate high-performance liquid chromatography (HPLC) method was developed for the assessme...

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Sci. Pharm. - ISSN 2218-0532