Next Article in Journal
Alcohol Dehydrogenases as Tools for the Preparation of Enantiopure Metabolites of Drugs with Methyl Alkyl Ketone Moiety
Previous Article in Journal
Correction: Budiarto, Bugi Ratno and Desriani. Detection of HER2 Gene Polymorphism in Breast Cancer: PCR Optimization Study. Sci. Pharm. 2016, 84, 103–111
 
 
Search for Articles:
Title / Keyword
Author / Affiliation / Email
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
 
Journals
Sci. Pharm.
Volume 77
Issue 1
10.3797/scipharm.0901-14
scipharm-logo
Submit to this Journal Review for this Journal Propose a Special Issue
► Article Menu

Article Menu

share Share announcement Help format_quote Cite question_answer Discuss in SciProfiles
Scientia Pharmaceutica is published by MDPI from Volume 84 Issue 3 (2016). Previous articles were published by another publisher in Open Access under a CC-BY (or CC-BY-NC-ND) licence, and they are hosted by MDPI on mdpi.com as a courtesy and upon agreement with Austrian Pharmaceutical Society (Österreichische Pharmazeutische Gesellschaft, ÖPhG).
first_page
settings
Order Article Reprints
Font Type:
Arial Georgia Verdana
Font Size:
Aa Aa Aa
Line Spacing:
Column Width:
Background:
Article

Short Total Synthesis of the Marine Alkaloid Subarine

by
Matthias LOTTER
and
Franz BRACHER
*
Department Pharmazie – Zentrum für Pharmaforschung, Ludwig-Maximilians-Universität München, Butenandtstr. 5–13, 81377 München, Germany
*
Author to whom correspondence should be addressed.
Sci. Pharm. 2009, 77(1), 1-8; https://doi.org/10.3797/scipharm.0901-14
Submission received: 9 January 2009 / Accepted: 4 February 2009 / Published: 5 February 2009
Versions Notes

Abstract

The marine benzo[c][2,7]naphthyridine alkaloid subarine is prepared in 4 steps, starting from commercially available 1,10-phenanthroline, via oxidative cleavage to the bipyridine-dicarboxylate, conversion to the mono(2-iodoanilide), and radical cyclization. The alkaloid does not show any significant antimicrobial or cytotoxic activity.
Keywords: Subarine; Alkaloid; Radical cyclization; Benzo[c][2,7]naphthyridine; Marine natural products Subarine; Alkaloid; Radical cyclization; Benzo[c][2,7]naphthyridine; Marine natural products

Share and Cite

MDPI and ACS Style

LOTTER, M.; BRACHER, F. Short Total Synthesis of the Marine Alkaloid Subarine. Sci. Pharm. 2009, 77, 1-8. https://doi.org/10.3797/scipharm.0901-14

AMA Style

LOTTER M, BRACHER F. Short Total Synthesis of the Marine Alkaloid Subarine. Scientia Pharmaceutica. 2009; 77(1):1-8. https://doi.org/10.3797/scipharm.0901-14

Chicago/Turabian Style

LOTTER, Matthias, and Franz BRACHER. 2009. "Short Total Synthesis of the Marine Alkaloid Subarine" Scientia Pharmaceutica 77, no. 1: 1-8. https://doi.org/10.3797/scipharm.0901-14

APA Style

LOTTER, M., & BRACHER, F. (2009). Short Total Synthesis of the Marine Alkaloid Subarine. Scientia Pharmaceutica, 77(1), 1-8. https://doi.org/10.3797/scipharm.0901-14

Article Metrics

Back to TopTop