Next Article in Journal
Alcohol Dehydrogenases as Tools for the Preparation of Enantiopure Metabolites of Drugs with Methyl Alkyl Ketone Moiety
Previous Article in Journal
Correction: Budiarto, Bugi Ratno and Desriani. Detection of HER2 Gene Polymorphism in Breast Cancer: PCR Optimization Study. Sci. Pharm. 2016, 84, 103–111
Article Menu

Article Versions

Export Article

Scientia Pharmaceutica is published by MDPI from Volume 84 Issue 3 (2016). Articles in this Issue were published by another publisher in Open Access under a CC-BY (or CC-BY-NC-ND) licence. Articles are hosted by MDPI on as a courtesy and upon agreement with Austrian Pharmaceutical Society (Österreichische Pharmazeutische Gesellschaft, ÖPhG).
Open AccessArticle
Sci. Pharm. 2009, 77(1), 1-8;

Short Total Synthesis of the Marine Alkaloid Subarine

Department Pharmazie – Zentrum für Pharmaforschung, Ludwig-Maximilians-Universität München, Butenandtstr. 5–13, 81377 München, Germany
Author to whom correspondence should be addressed.
Received: 9 January 2009 / Accepted: 4 February 2009 / Published: 5 February 2009
PDF [184 KB, uploaded 20 December 2016]


The marine benzo[c][2,7]naphthyridine alkaloid subarine is prepared in 4 steps, starting from commercially available 1,10-phenanthroline, via oxidative cleavage to the bipyridine-dicarboxylate, conversion to the mono(2-iodoanilide), and radical cyclization. The alkaloid does not show any significant antimicrobial or cytotoxic activity.
Keywords: Subarine; Alkaloid; Radical cyclization; Benzo[c][2,7]naphthyridine; Marine natural products Subarine; Alkaloid; Radical cyclization; Benzo[c][2,7]naphthyridine; Marine natural products
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

Share & Cite This Article

MDPI and ACS Style

LOTTER, M.; BRACHER, F. Short Total Synthesis of the Marine Alkaloid Subarine. Sci. Pharm. 2009, 77, 1-8.

Show more citation formats Show less citations formats

Article Metrics

Article Access Statistics



[Return to top]
Sci. Pharm. EISSN 2218-0532 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top