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Short Total Synthesis of the Marine Alkaloid Subarine
Department Pharmazie – Zentrum für Pharmaforschung, Ludwig-Maximilians-Universität München, Butenandtstr. 5–13, 81377 München, Germany
Author to whom correspondence should be addressed.
Received: 9 January 2009 / Accepted: 4 February 2009 / Published: 5 February 2009
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Abstract The marine benzo[c][2,7]naphthyridine alkaloid subarine is prepared in 4 steps, starting from commercially available 1,10-phenanthroline, via oxidative cleavage to the bipyridine-dicarboxylate, conversion to the mono(2-iodoanilide), and radical cyclization. The alkaloid does not show any significant antimicrobial or cytotoxic activity.
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LOTTER, M.; BRACHER, F. Short Total Synthesis of the Marine Alkaloid Subarine. Sci. Pharm. 2009, 77, 1-8.
LOTTER M, BRACHER F. Short Total Synthesis of the Marine Alkaloid Subarine. Scientia Pharmaceutica. 2009; 77(1):1-8.
LOTTER, Matthias; BRACHER, Franz. 2009. "Short Total Synthesis of the Marine Alkaloid Subarine." Sci. Pharm. 77, no. 1: 1-8.
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