Short Total Synthesis of the Marine Alkaloid Subarine
Department Pharmazie – Zentrum für Pharmaforschung, Ludwig-Maximilians-Universität München, Butenandtstr. 5–13, 81377 München, Germany
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Sci. Pharm. 2009, 77(1), 1-8; https://doi.org/10.3797/scipharm.0901-14
Submission received: 9 January 2009
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Accepted: 4 February 2009
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Published: 5 February 2009
Abstract
The marine benzo[c][2,7]naphthyridine alkaloid subarine is prepared in 4 steps, starting from commercially available 1,10-phenanthroline, via oxidative cleavage to the bipyridine-dicarboxylate, conversion to the mono(2-iodoanilide), and radical cyclization. The alkaloid does not show any significant antimicrobial or cytotoxic activity.
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MDPI and ACS Style
LOTTER, M.; BRACHER, F. Short Total Synthesis of the Marine Alkaloid Subarine. Sci. Pharm. 2009, 77, 1-8. https://doi.org/10.3797/scipharm.0901-14
AMA Style
LOTTER M, BRACHER F. Short Total Synthesis of the Marine Alkaloid Subarine. Scientia Pharmaceutica. 2009; 77(1):1-8. https://doi.org/10.3797/scipharm.0901-14
Chicago/Turabian StyleLOTTER, Matthias, and Franz BRACHER. 2009. "Short Total Synthesis of the Marine Alkaloid Subarine" Scientia Pharmaceutica 77, no. 1: 1-8. https://doi.org/10.3797/scipharm.0901-14
