Preservative Evaluation of Caprylic Acid Derivatives in Aluminium Hydroxide Gel – USP

Jasmine CHAUDHARY; Archana K. RAJPAL; Vikramjeet JUDGE; Rakesh NARANG; Balasubramanian NARASIMHAN

doi:10.3797/scipharm.0807-24

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Article

2 September 2008

Preservative Evaluation of Caprylic Acid Derivatives in Aluminium Hydroxide Gel – USP

and

Department of Pharmaceutical Sciences, Guru Jambheshwar University of Science and Technology, Hisar-125001, India

Faculty of Pharmaceutical Sciences, Maharshi Dayanand University, Rohtak-124001, India

Author to whom correspondence should be addressed.

Sci. Pharm.2008, 76(3), 533-540;https://doi.org/10.3797/scipharm.0807-24

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Abstract

The potential derivatives of caprylic acid were subjected to preservative efficacy testing in Aluminium Hydroxide Gel – USP using Staphylococcus aureus MTCC 2901, Bacillus subtilis MTCC 2063, and Escherichia coli MTCC 1652 as representative challenging microorganisms for antimicrobial effectiveness testing as per USP 2004. The caprylic acid derivative, capryl hydrazide exhibited better preservative efficacy than caprylic acid as well as the standard preservatives, methyl paraben and propyl paraben.

Keywords:

Caprylic acid; Capryl hydrazide; p-Chlorocaprylanilide; Preservative efficacy

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